“…Moreover, nanosilicates can also be combined with various ranges of natural and synthetic polymeric hydrogel systems including gelatin, 19,51 kappa carrageenan, 36,52 and poly(ethylene oxide) 53 for sustained and prolonged delivery of therapeutic proteins. These nanocomposite systems have been investigated for both injectable systems 54 and 3D printed constructs. 29,55,56 By localizing and patterning therapeutic protein, regionalized differentiation of stem cells on gradient scaffolds can be obtained to mimic the osteochondral interface.…”