Proposed Definitions and Criteria for Reporting Time Frame, Outcome, and Complications For Clinical Orthopedic Studies in Veterinary Medicine

Cook, James L.; Evans, Richard B.; Conzemius, Michael G.; Lascelles, B. Duncan X.; McIlwraith, C. Wayne; Pozzi, Antonio; Clegg, Peter; Innes, John F.; Schulz, Kurt S.; Houlton, J. E. F.; Fortier, Lisa A.; Cross, Alan R.; Hayashi, Kei; Kapatkin, Amy S.; Brown, Dorothy Cimino; Stewart, Alban

doi:10.1111/j.1532-950x.2010.00763.x

Cited by 311 publications

(484 citation statements)

References 4 publications

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“…Complications were classified depending on whether further surgical or medical treatment was required to resolve (Cook and others 2010). SSI was described according to proposed definitions of the US Centre for Disease Control and Prevention (Brown 2013).…”

Section: Methodsmentioning

confidence: 99%

Client‐assessed long‐term outcome in dogs with surgical site infection following tibial plateau levelling osteotomy

Brown

Maddox

Siles³

2016

Veterinary Record

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The objective of this study was to describe client-assessed long-term functional outcome following surgical site infection (SSI) in dogs that underwent tibial plateau levelling osteotomy (TPLO) and identify predictive factors for infection development and management. This study is a retrospective clinical case series. Clinical records of dogs (n=545) undergoing TPLO surgery (n=683) were reviewed. Signalment, clinical details, surgical management and postoperative complications were recorded. Multilevel analysis was used to assess the relationship between signalment and clinical variables and the subsequent development of SSI. Additionally, SSIs were analysed to identify predictors for management. Long-term functional outcome was evaluated using a previously validated clinical metrology instrument (Liverpool Osteoarthritis in Dogs (LOAD) questionnaire). SSI occurred in 4.7 per cent (95 per cent CI 3.3 per cent to 6.5 per cent) procedures. Of the dogs with SSI, 37.5 per cent required implant retrieval and later onset SSI was associated with increased requirement for retrieval (P=0.04). There was no significant difference in LOAD score (P=0.7) in dogs with or without SSI. Crossbreed dogs had a lower risk of developing SSI (P=0.03). There was no association between SSI and long-term functional outcome (as assessed by LOAD) in dogs following TPLO. Later onset of SSI is more likely to require implant retrieval to resolve. Crossbreed dogs may be at reduced risk of developing SSI.

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Section: Methodsmentioning

confidence: 99%

Client‐assessed long‐term outcome in dogs with surgical site infection following tibial plateau levelling osteotomy

Brown

Maddox

Siles³

2016

Veterinary Record

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“…8,12-14,15,17,18 Importantly, client-owned dogs and horses (rather than research dogs and horses) are also afflicted with cartilage defects resulting from osteochondrosis, trauma, and athletic injuries with symptomatology and treatment options that are essentially identical to those in humans. 8,19,20 These spontaneously occurring cartilage defects provide an optimal opportunity for critically assessing cartilage repair strategies for human application, in that the mechanisms of disease are the same as those seen clinically, all of the articular tissues are involved, and assessments of efficacy can be based on clinically relevant measures of return to function. 20 …”

Section: Historymentioning

confidence: 99%

Animal models of cartilage repair

Cook

Hung

Kuroki

et al. 2014

Bone & Joint Research

137

166

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Cartilage repair in terms of replacement, or regeneration of damaged or diseased articular cartilage with functional tissue, is the ‘holy grail’ of joint surgery. A wide spectrum of strategies for cartilage repair currently exists and several of these techniques have been reported to be associated with successful clinical outcomes for appropriately selected indications. However, based on respective advantages, disadvantages, and limitations, no single strategy, or even combination of strategies, provides surgeons with viable options for attaining successful long-term outcomes in the majority of patients. As such, development of novel techniques and optimisation of current techniques need to be, and are, the focus of a great deal of research from the basic science level to clinical trials. Translational research that bridges scientific discoveries to clinical application involves the use of animal models in order to assess safety and efficacy for regulatory approval for human use. This review article provides an overview of animal models for cartilage repair.Cite this article: Bone Joint Res 2014;4:89–94.

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“…[24]. Successful outcomes were also obtained based upon in-house re-evaluation for the 3 dogs returned to our hospital for repeat examination and based upon phone interview for the one dog that was not returned for re-evaluation.…”

Section: Resultsmentioning

confidence: 99%

The effect of platelet-rich plasma on osseous healing in dogs undergoing high tibial osteotomy

2017

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ObjectivesThe purpose of this study was to investigate whether platelet-rich plasma (PRP) enhances osseous healing in conjunction with a high tibial osteotomy in dogs.Study designRandomized controlled trial.MethodsSixty-four client-owned pet dogs with naturally occurring rupture of the anterior cruciate ligament and that were to be treated with a high tibial osteotomy (tibial plateau leveling osteotomy) were randomized into the treatment or control group. Dogs in the treatment group received autologous platelet-rich plasma activated with calcium chloride and bovine thrombin to produce a well-formed PRP gel that was placed into the osteotomy at the time of surgery. Dogs in the control group received saline lavage of the osteotomy. All dogs had the osteotomy stabilized with identical titanium alloy implants and all aspects of the surgical procedure and post-operative care were identical among dogs of the two groups. Bone healing was assessed at exactly 28, 49, and 70 days after surgery with radiography and ultrasonography and with MRI at day 28. The effect of PRP on bone healing was assessed using a repeated measures analysis of covariance with radiographic and ultrasonographic data and using a t-test with the MRI data.ResultsSixty dogs completed the study. There were no significant differences in age, weight, or gender distribution between the treatment and control groups. Twenty-seven dogs were treated with PRP and 33 were in the control group. The average platelet concentration of the PRP was 1.37x106 platelets/μL (±489x103) with a leukocyte concentration of 5.45x103/μL (±3.5x103). All dogs demonstrated progressive healing over time and achieved clinically successful outcomes. Time since surgery and patient age were significant predictors of radiographic healing and time since surgery was a significant predictor of ultrasonographic assessment of healing. There was no significant effect of PRP treatment as assessed radiographically, ultrasonographically, or with MRI.ConclusionThe PRP used in this study did not hasten osseous union in dogs treated with a high tibial osteotomy.

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Proposed Definitions and Criteria for Reporting Time Frame, Outcome, and Complications For Clinical Orthopedic Studies in Veterinary Medicine

Cited by 311 publications

References 4 publications

Client‐assessed long‐term outcome in dogs with surgical site infection following tibial plateau levelling osteotomy

Client‐assessed long‐term outcome in dogs with surgical site infection following tibial plateau levelling osteotomy

Animal models of cartilage repair

The effect of platelet-rich plasma on osseous healing in dogs undergoing high tibial osteotomy

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