Propranolol

Al-Majed, Abdulhakeem A.; Bakheit, Ahmed H.; Abdel‐Aziz, Hatem A.; AlAjmi, Fahad; AlRabiah, Haitham

doi:10.1016/bs.podrm.2017.02.006

Cited by 59 publications

(40 citation statements)

References 71 publications

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“…Propranolol (PRO) 4 is a well-known non-selective beta-adrenergic receptor (β-AR) antagonist (beta-blocker), which is widely typically prescribed for heart disease, hypertension or angina. In addition, previous preclinical studies 5 , 6 have also found that β-AR signaling plays an essential role in cancer progression and the activation of β-AR promotes angiogenesis.…”

Section: Introductionmentioning

confidence: 99%

Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in Human Ovarian Cancer

Zhao¹,

Fan²,

Shi³

et al. 2020

J. Cancer

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Propranolol has a significant anti-cancer effect towards various cancers. Our study aimed at investigating the underlying mechanism of Propranolol's therapeutic effect towards ovarian cancer. Specifically, Propranolol significantly reduced the viability of human ovarian cancer cell lines SKOV-3 and A2780 in a dose-and time-dependent manner. Flow cytometry analysis revealed that Propranolol induced the cell cycle arrest at G2/M phase therefore leading to apoptosis. Moreover, autophagy inhibitor 3-MA markedly enhanced the Propranolol-induced apoptosis. In addition, reactive oxygen species (ROS) increased dramatically after Propranolol treatment and Propranolol activated the phosphorylation of JNK. What is more, p38 inhibitor SB203580 and JNK inhibitor SP600125 attenuated the upregulated expression of LC3-II and cleaved-caspase-3 by the effect of Propranolol. ROS exclusive inhibitor antioxidant N-acetyl cysteine (NAC) weakens the phosphorylation of JNK proteins induced by Propranolol. In summary, these results suggested that Propranolol induced cell apoptosis and protective autophagy through the ROS/JNK signaling pathway in human ovarian cancer cells.

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Section: Introductionmentioning

confidence: 99%

Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in Human Ovarian Cancer

Zhao¹,

Fan²,

Shi³

et al. 2020

J. Cancer

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“…CVDs are the major cause of morbidity and mortality, resulting in most number of deaths in the western world. Current beta‐blockers are structural variants of aryl‐oxy propanolamines and are reported to possess many unwanted side‐effects due to lack of selectivity . Hence, development of new beta‐blockers with higher specificity and lower side effects is crucial.…”

Section: Discussionmentioning

confidence: 99%

Identification of a α‐helical molten globule intermediate and structural characterization of β‐cardiotoxin, an all β‐sheet protein isolated from the venom of Ophiophagus hannah (king cobra)

et al. 2019

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β-Cardiotoxin is a novel member of the snake venom three-finger toxin (3FTX) family. This is the first exogenous protein to antagonize β-adrenergic receptors and thereby causing reduction in heart rates (bradycardia) when administered into animals, unlike the conventional cardiotoxins as reported earlier. 3FTXs are stable all β-sheet peptides with 60-80 amino acid residues. Here, we describe the three-dimensional crystal structure of β-cardiotoxin together with the identification of a molten globule intermediate in the unfolding pathway of this protein. In spite of the overall structural similarity of this protein with conventional cardiotoxins, there are notable differences observed at the loop region and in the charge distribution on the surface, which are known to be critical for cytolytic activity of cardiotoxins. The molten globule intermediate state present in the thermal unfolding pathway of β-cardiotoxin was however not observed during the chemical denaturation of the protein. Interestingly, circular dichroism (CD) and NMR studies revealed the presence of α-helical secondary structure in the molten globule intermediate. These results point to substantial conformational plasticity of β-cardiotoxin, which might aid the protein in responding to the sometimes conflicting demands of structure, stability, and function during its biological lifetime. PDB Code(s): 3PLC;

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“…Propranolol brands are Inderal and Peranol, which are components of beta-1 and beta-2 receptor blocker drugs prescribed in pills for treating arrhythmia or blood pressure [2]. The side effects of their consumption are drowsiness, blurred vision, weakness and fatigue, dizziness, difficulty in defecation, sleep problems and decreased sexual ability [2]. Some studies investigate the adverse effect of beta-blocker drugs on motility of sperm, acrosome reaction and sperm capacity.…”

Section: Propranololmentioning

confidence: 99%

The Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Mice

Mohammadi

Beheshti

Elyasi

et al. 2020

JPRI

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The aim of this study was to investigate the effects of propranolol on sperms, histopathology of testes, and CatSper 2 gene and protein expression in adult mice. 18 adult male mice were randomly divided into control, propranolol 1 (receiving 10 mg/kg dose) and propranolol 2 group (receiving 15 mg/kg dose for 35 days). The mean amount of sperm parameters in the propranolol 1 and propranolol 2 groups was significantly lower than the control group (p<0.05). CatSper2 gene and protein expression have significantly decreased in propranolol 1 and propranolol 2 groups compared to the control group (P<0.05). Reduction of CatSper2 gene and protein expression in low dose of propranolol was more severe than high dose. In testicular tissues of the propranolol 1 group, vacuoles and necrosis in the germinal epithelium were observed, and in testicular tissues of propranolol 2 group decrease in the thickness of the germinal epithelium, some vacuoles and necrosis were observed in germinal epithelium as well as congestion in the interstitial space. The mean value of thiol and catalase enzyme in the propranolol 1 and propranolol 2 groups, and the mean value of superoxide dismutase in propranolol 1 group, were significantly different compared to the control group (P<0.05).

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Propranolol

Cited by 59 publications

References 71 publications

Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in Human Ovarian Cancer

Propranolol induced apoptosis and autophagy via the ROS/JNK signaling pathway in Human Ovarian Cancer

Identification of a α‐helical molten globule intermediate and structural characterization of β‐cardiotoxin, an all β‐sheet protein isolated from the venom of Ophiophagus hannah (king cobra)

The Effect of Propranolol on Sperm Parameters, CatSper 2 Gene and Protein Expression, and Oxidative Stress in Adult Mice

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