Propranolol serum levels during twenty‐four hours

Vervloet, E.; Pluym, Ben; Cilissen, J.; Köhlen, K; Merkus, F. W. H. M.

doi:10.1002/cpt1977226853

Cited by 35 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…-1), plasma propranolol concentrations reached peak values approximately two hours after each oral dose and, during the day, there was a wide fluctuation in the plasma propranolol levels, findings which are similar to those reported by Vervloet et al (1977).…”

Section: Resultssupporting

confidence: 83%

Relationship between plasma propranolol concentration and relief of essential tremor.

Jefferson¹,

Jenner²,

Marsden³

1979

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

SUMMARYThe relationship between plasma propranolol concentration and relief of essential tremor was examined in 11 patients during treatment with oral racemic propranolol in doses of 30 to 640 mg/day. Although propranolol decreased tremor in all 11 patients, the degree of improvement varied widely in individuals (mean 51%, range 25-90%), and was not related directly to the plasma propranolol concentration. In seven patients, optimum reduction in tremor occurred at plasma propranolol concentrations below 20 ng/ml (0.077 jumol/l) and, in three others, below 40 ng/ml (0.154 Lmol/l). It is concluded that the optimum response of essential tremor to propranolol is achieved at relatively low plasma propranolol levels, levels which are obtained by daily propranolol doses of 120-240 mg.

show abstract

Section: Resultssupporting

confidence: 83%

Relationship between plasma propranolol concentration and relief of essential tremor.

Jefferson¹,

Jenner²,

Marsden³

1979

Journal of Neurology, Neurosurgery & Psychiatry

View full text Add to dashboard Cite

show abstract

“…2). this phenomenon, also detectable in the data of Vervloet et al (16) may be related to diurnal changes in hepatic blood flow. In the present study, systemic availability was calculated with an assumed hepatic blood flow of 1.53 L/min.…”

Section: Discussionmentioning

confidence: 48%

“…The significance of the first-pass effect during multiple dosing has also been studied (2,6,16,17). Evans and Shand noted a greater than anticipated accumulation during multiple dosing, based upon the drug's half-life.…”

Section: Introductionmentioning

confidence: 99%

Variable first-pass elimination of propranolol following single and multiple oral doses in hypertensive patients

Wargin

Sawchuk

McBride

et al. 1982

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

The disposition of orally administered propranolol has been studied in twelve patients with mild to moderate hypertension. Each patient received single doses of 40, 80, and 160 mg. Serial blood samples were obtained and quantitated using a sensitive gas chromatographic analytical technique. Ten of the twelve patients received 40 mg doses of propranolol every 6 hours for 5 doses. Blood samples were obtained after administration of the first, second, third, and fifth doses. Substantial intersubject variability in the areas under the bloodconcentration-time profiles (AUC) was observed. Evidence for a nonlinear first-pass effect was not obtained in all patients. The patients displaying a nonlinear relationship between dose and AUC for single propranolol doses consistently showed a similar relationship during multiple dosing. Blood levels obtained following the evening dose (08h00 to 14h00) appeared to be lower than expected based on multiple-dosing pharmacokinetic principles. These findings suggest that monitoring propranolol blood levels is the most viable way to ascertain therapeutic concentrations of this drug.

show abstract

“…Systolic arterial blood pressure rose significantly towards the end of this study (4, 6, and 8 h after the oral dose) but was not accompanied by any consistent change in diastolic pressure. The mechanisms of the antihypertensive effect of I)-adrenoceptor blocking drugs is unknown, and the significance of the correlation between ,B- Studies with propranolol which also shows a very wide-interindividual variation in plasma concentration (Shand, Nuckolls & Oates, 1970) due to first-pass metabolism have failed to find a correlation between serum drug concentrations and arterial blood pressures during interdose periods (Vervloet, Pluym, Cilissen, Kohlen, & Merkus, 1977).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics, beta‐adrenoceptor blockade and anti‐hypertensive action of labetalol during chronic oral treatment

Sanders¹,

Davies²,

Rawlins³

1980

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 fl-adrenoceptor blockade, plasma labetalol concentrations and anti-hypertensive actions were investigated at 2 hourly intervals during the interdose period of chronic oral therapy in six hypertensive patients.2 f,-adrenoceptor blockade varied during the inter-dose period and was maximal 2 and 4 h after the oral dose (P < 0.05). 3 Systolic pressure rose during the interdose period (P < 0.05). A significant correlation was found between the degree of fl-adrenoceptor blockade and the change in systolic pressure at 2 h after the oral dose.4 Efficacy of labetalol as a P-adrenoceptor antagonist and anti-hypertensive drug was assessed 2 h after an oral dose during chronic eight hourly dosage in sixteen hypertensive patients. Pharmacokinetics of labetalol were studied in the same patients. 5 Peak plasma labetalol concentration occurred 2 h after the oral dose and subsequently the plasma concentration declined monoexponentially.6 The steady state concentration (Css) of labetalol was correlated significantly with the daily oral dose in mg kg , the mid point labetalol concentration (Cmax + Cmin) and the isoprenaline dose ratio-I 2 at 2 h after the oral dose.7 No correlation was found between the antihypertensive effect and the Css ng ml-1 labetalol or between the isoprenaline dose ratio-I and the Css labetalol ng ml-.

show abstract

Propranolol serum levels during twenty‐four hours

Cited by 35 publications

References 2 publications

Relationship between plasma propranolol concentration and relief of essential tremor.

Relationship between plasma propranolol concentration and relief of essential tremor.

Variable first-pass elimination of propranolol following single and multiple oral doses in hypertensive patients

Pharmacokinetics, beta‐adrenoceptor blockade and anti‐hypertensive action of labetalol during chronic oral treatment

Contact Info

Product

Resources

About