Propranolol therapy for infantile hemangioma is less toxic but longer in duration than corticosteroid therapy

Sawa, Kathryn; Yazdani, Arjang; Rieder, Michael J.; Filler, Guido

doi:10.4172/plastic-surgery.1000892

Cited by 2 publications

(4 citation statements)

References 15 publications

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“…6 Sawa et al found excellent treatment response to both propranolol and prednisone for infantile hemangiomas, at a median dose of 5 mg/kg/day for prednisone (n = 11) and 2 mg/kg/day for propranolol (n = 7). 7 The difference between the two drugs was significantly longer treatment duration for propranolol with a mean duration of 372 days. 7 Side effects of corticosteroid treatment noted were increase in body-mass index (BMI) and systolic blood pressure.…”

Section: Discussionmentioning

confidence: 99%

“…7 The difference between the two drugs was significantly longer treatment duration for propranolol with a mean duration of 372 days. 7 Side effects of corticosteroid treatment noted were increase in body-mass index (BMI) and systolic blood pressure. 7 Propranolol is well documented as an effective treatment modality for infantile hemangiomas.…”

Section: Discussionmentioning

confidence: 99%

“…7 Side effects of corticosteroid treatment noted were increase in body-mass index (BMI) and systolic blood pressure. 7 Propranolol is well documented as an effective treatment modality for infantile hemangiomas. 1,4,5,7 Its mechanism of action in hemangiomas is related to its beta-2 inhibitory effect which decreases the release of vasodilators such as nitric oxide.…”

Section: Discussionmentioning

confidence: 99%

“…7 Propranolol is well documented as an effective treatment modality for infantile hemangiomas. 1,4,5,7 Its mechanism of action in hemangiomas is related to its beta-2 inhibitory effect which decreases the release of vasodilators such as nitric oxide. Vasoconstriction of the feeding capillaries results for the early visible changes in the color of the lesion.…”

Section: Discussionmentioning

confidence: 99%

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An Initial Overview of Management and Treatment Outcomes for Head and Neck Hemangiomas

Fernandez¹

2018

Philipp J Otolaryngol Head Neck Surg

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Objective: To provide an initial overview of the outcomes of different treatment modalities used for hemangiomas. Methods: Design: Case Series Setting: Tertiary National University Hospital Participants: Records of 21 patients diagnosed with head and neck hemangiomas in the Philippine General Hospital Department of Otorhinolaryngology from 2009 to 2014 were reviewed. Results: Majority of the patients were female (61.9%) and in the pediatric age group (57.1%). Of the 21 patients, 6 underwent medical management, 13 had surgical management, 1 had both medical and surgical management, and 1 opted to observe the lesion. All patients treated with propranolol observed a decrease in the size of the lesion. Seven out of the 13 patients had radiofrequency ablation; all had gross residual lesion. Six of the 13 underwent excision, with complete excision being achieved in 5 of 6 cases. Conclusion: Treatment response of patients in this series with hemangiomas of the head and neck to propranolol at a dose of 1 to 2 mg/kg/day may reflect international data. Outcomes analysis for radiofrequency ablation and surgical excision requires a longer duration of follow-up. Keywords: propranolol hydrochloride, prednisone, pulsed radiofrequency treatment, capillary hemangioma, vascular tissue neoplasms

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Section: Discussionmentioning

confidence: 99%