Propranolol was effective in treating cutaneous infantile haemangiomas in Thai children

Techasatian, Leelawadee; Komwilaisak, Patcharee; Panombualert, Sunee; Uppala, Rattapon; Jetsrisuparb, Charoon

doi:10.1111/apa.13378

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…This cutaneous lesion has its own characteristics of natural history of growth pattern, which consists of 3 phases: proliferative, involuting, and involuted. 21,22 Cutaneous lesions usually occur as preliminary light patches before growing rapidly in the proliferative phase. This pattern can be seen within a few weeks to a few months.…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Birthmarks: A Prospective Survey in 1000 Neonates

Techasatian

Sanaphay

Paopongsawan

et al. 2019

Global Pediatric Health

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The majority of neonatal cutaneous conditions are benign and self-limited. However, some skin infections and specific birthmarks are serious and require proper management approaches. This study was a prospective survey of 1000 consecutive newborns at a tertiary care center in Northeast Thailand from September 2015 to 2016, which aimed to identify various cutaneous findings in newborns during their first 5 days of life. The authors found that Mongolian spots (66.7%) and sebaceous gland hyperplasia (60.9%) were the 2 most common cutaneous conditions found in the Thai population. Salmon patches were the most frequent vascular birthmarks (36%), followed by infantile hemangiomas (1.1%) and port wine stains (0.7%). Although majority of the neonatal cutaneous conditions are benign and self-limited, there were 8 cases (0.8%) of bullous impetigo in which both systemic and topical antibiotics were promptly prescribed.

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Section: Discussionmentioning

confidence: 99%

“…However, there are some problematic hemangiomas that require early treatment. 23 The current treatment of choice is oral or topical propranolol, which many studies 21,[24][25][26] from around the world have shown to be effective in treating cutaneous lesions.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Birthmarks: A Prospective Survey in 1000 Neonates

Techasatian

Sanaphay

Paopongsawan

et al. 2019

Global Pediatric Health

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“…This may due to the fact that the early cutaneous lesion of infantile hemangioma usually presents as a faint erythematous patch that is difficult to be seen within the first 5 days of life. 14,15 More over infantile hemangiomas are more common in preterm infants, while the population in the present study were all full-term born which may affect the distribution of the cutaneous findings.…”

Section: Discussionmentioning

confidence: 78%

Neonatal Birthmarks at the 4 Central Hospitals in Vientiane Capital, Lao PDR

Sanaphay

Sengchanh

Phengsavanh

et al. 2021

Global Pediatric Health

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Newborn skin disorders are quite common and happen to occur during the neonatal period. Most of the birthmarks are transient; however, worried parents often seek medical advice from their child’s physician regarding skin lesions. Thus, it is important to differentiate the skin lesions from pathologic ones to avoid unnecessary diagnostic or therapeutic procedures. This is the first published study in Lao neonates that carried out the data from 4 central hospitals in Vientiane Capital, Lao PDR from September 2019 to February 2020. Among 500 neonates, Sebaceous gland hyperplasia (53%), Mongolian patches (46.6%), and Erythema toxicum neonatorum (30%) were the 3 most common cutaneous conditions found in the Lao newborns. From a clinical point of view, these findings are often a source of parental anxiety and medical concern for inexperienced clinicians.

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“…While not statistically significant, interestingly, 62.5% of the children in this study who experienced complications were initiated at a 2 mg/kg/day dose, compared with 27.8% of the general study population. A small Thai cases series found children who were given 2 mg/kg/day of propranolol who experienced hypoglycaemia 16 did not experience hypoglycaemia when dropped to 1 mg/kg/day and then slowly increased in 0.5 mg/kg/day increments to 2 mg/kg/day. Herman et al 19 noted similarly in their study.…”

Section: Discussionmentioning

confidence: 99%

Immediate possible adverse event rates in infants treated with oral propranolol for infantile haemangiomas at an Australian urban tertiary hospital between 2016 and 2019

Adams

Ryan

2022

Aust J Dermatology

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Background/Objectives: Infantile haemangiomas (IH) are common benign tumours of childhood. The current guideline recommended treatment is oral propranolol, the use of which for IH is relatively recent and there are no safety audits in Australian children published. As a result, it is a primarily inpatient initiated treatment. The aim of this study was to examine the short-term complication rates in infants treated with oral propranolol for IH. Methods:Retrospective case note review of IH patients initiated on oral propranolol admitted to the day-unit of tertiary metropolitan hospital in an Australia capital city, from January 2016 to December 2019.Results: Overall, 72 children were included in the study. Mean age at time of admission was 3.8 ± 2 months. Eight patients (11.1%) experienced complications during their initiation admission. Pulmonary complications (oxygen desaturation, wheeze, increased respiratory rate) was the most common type. No children required high-dependency or intensive care unit admission. The children who experienced complications had a mean age of 2.4 ± 1.2 months; t-test of equality of means found a relationship between propranolol-associated complication rate and age (p = 0.007). All other patient or admission characteristics were not associated with complication events (all p > 0.05). Conclusions:Propranolol is a safe, effective and well-tolerated treatment in Australian children with IH. This study demonstrates younger infants will most likely benefit from inpatient initiation. More research needs to be done to characterise the risk profile of propranolol initiation for IH.

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Propranolol was effective in treating cutaneous infantile haemangiomas in Thai children

Cited by 9 publications

References 22 publications

Neonatal Birthmarks: A Prospective Survey in 1000 Neonates

Neonatal Birthmarks: A Prospective Survey in 1000 Neonates

Neonatal Birthmarks at the 4 Central Hospitals in Vientiane Capital, Lao PDR

Immediate possible adverse event rates in infants treated with oral propranolol for infantile haemangiomas at an Australian urban tertiary hospital between 2016 and 2019

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