Ankle sprains are the most common injury in physically active people who practice physical activities that requires jumping, changing direction, pivoting. Practically these activities are seen in almost every sport, no matter if it is with professional or recreational purposes. A lot of individuals are at increased risk of ankle sprain. Acute ankle sprain leads to weakening of the passive and dynamic restrains, leaving the joint unprotected, possibility of reinjury, chronic instability leading to long term disability. That is why a lot of authors stopped their attention on looking for proper treatment and prevention for ankle sprain. The purpose of the present report is to summarize the effectiveness of all treatment methods and to point out the best possible way to manage ankle sprain. It is a systematic review study, based on recent literature of the given topic. The data is sorted out from different sources of information: specific books concerning ankle functional anatomy and kinesiology, physiotherapy in ankle instability rehabilitation; published articles; internet sources-pubmed, medline etc. Some researchers showed the relationship between poor ankle proprioception and balance abilities. Others assessed joint position sense to plantar flexors and the peroneal muscles activity. They all agree that proprioception training plays important role in prevention of chronic ankle instability and it is of a great importance to improve it to reduce ankle sprain accidents.