Propuesta para seleccionar aceites esenciales de plantas de Colombia para investigación con base en su citotoxicidad

Velandia, Sindi Alejandra; Flechas, María Camila; Stashenko, Elena E.; Jimenez, Raquel Elvira Ocazionez

doi:10.17533/udea.vitae.v23n1a03

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…28 Although there are no reports in humans, the S. aratocensis essential oil has demonstrated cytotoxicity to mycobacteria. 29 The essential oil from C. odorata , a related species to C. pellia , resulted toxic in human breast and cervical cancer and embryonic kidney cell lines, 30 whereas the flavonoids and steroids from C. hirsute and C. squalida species show antimicrobial activity. 31 The synonymous genus Eupatorium has extensively demonstrated antimicrobial properties.…”

Section: Discussionmentioning

confidence: 99%

In vitro Safety Assessment of Extracts and Compounds From Plants as Sunscreen Ingredients

Flórez González,

Stashenko,

Ocazionez

et al. 2024

Int J Toxicol

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This work investigated the safety of extracts obtained from plants growing in Colombia, which have previously shown UV-filter/antigenotoxic properties. The compounds in plant extracts obtained by the supercritical fluid (CO2) extraction method were identified using gas chromatography coupled to mass spectrometry (GC/MS) analysis. Cytotoxicity measured as cytotoxic concentration 50% (CC50) and genotoxicity of the plant extracts and some compounds were studied in human fibroblasts using the trypan blue exclusion assay and the Comet assay, respectively. The extracts from Pipper eriopodon and Salvia aratocensis species and the compound trans-β-caryophyllene were clearly cytotoxic to human fibroblasts. Conversely, Achyrocline satureioides, Chromolaena pellia, and Lippia origanoides extracts were relatively less cytotoxic with CC50 values of 173, 184, and 89 μg/mL, respectively. The C. pellia and L. origanoides extracts produced some degree of DNA breaks at cytotoxic concentrations. The cytotoxicity of the studied compounds was as follows, with lower CC50 values representing the most cytotoxic compounds: resveratrol (91 μM) > pinocembrin (144 μM) > quercetin (222 μM) > titanium dioxide (704 μM). Quercetin was unique among the compounds assayed in being genotoxic to human fibroblasts. Our work indicates that phytochemicals can be cytotoxic and genotoxic, demonstrating the need to establish safe concentrations of these extracts for their potential use in cosmetics.

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Section: Discussionmentioning

confidence: 99%

In vitro Safety Assessment of Extracts and Compounds From Plants as Sunscreen Ingredients

Flórez González,

Stashenko,

Ocazionez

et al. 2024

Int J Toxicol

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“…Velandia et al indicated that the EO of T. diffusa presents a tendency towards high toxicity, with CC 50 values of 83-199 µg/mL for different cell lines [118].…”

Section: Cytotoxicitymentioning

confidence: 99%

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Parra-Naranjo,

Delgado-Montemayor,

Salazar-Aranda

et al. 2023

Pharmaceuticals

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Turnera is a genus of plants whose biological activity has been widely studied. The importance of this genus, particularly Turnera diffusa, as a source of treatment for various conditions is evidenced by the large number of new studies that have evaluated its biological activity. Accordingly, the objective of this review was to compile the information published in the last ten years concerning the biological activities reported for Turnera spp. The present work includes 92 publications that evaluate 29 bioactivities and toxicological and genotoxic information on five species of this genus. Among the pharmacological effects reported, the antioxidant, hepatoprotective, neuroprotective, hypoglycemic, and aphrodisiac activities seem more promising. Phytochemicals and standardized plant extracts could offer alternative therapeutic remedies for various diseases. Although several flavonoids, cyanogenic glycosides, monoterpenoids, triterpenoids, and fatty acids have been isolated for Turnera plants, future research should focus on the identification of the main active principles responsible for these pharmacological activities, as well as to perform clinical trials to support the laboratory results.

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Study of Essential Oils from Leaves of Asteraceae Family Species Ageratina dendroides and Gynoxys verrucosa

Valarezo

Aguilera-Sarmiento

Meneses

et al. 2021

Journal of Essential Oil Bearing Plants

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Propuesta para seleccionar aceites esenciales de plantas de Colombia para investigación con base en su citotoxicidad

Cited by 4 publications

References 25 publications

In vitro Safety Assessment of Extracts and Compounds From Plants as Sunscreen Ingredients

In vitro Safety Assessment of Extracts and Compounds From Plants as Sunscreen Ingredients

Bioactivity of the Genus Turnera: A Review of the Last 10 Years

Study of Essential Oils from Leaves of Asteraceae Family Species Ageratina dendroides and Gynoxys verrucosa

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