Propylene glycol guluronate sulfate (PGGS) reduces lipid accumulation via AMP-activated kinase activation in palmitate-induced HepG2 cells

Meng, Xin; Sun, Yang; Chen, Haijiao; Li, Quancai; Dun, Yunlou; Guan, Huashi; Hao, Jiejie; Li, Chunxia

doi:10.1016/j.ijbiomac.2018.03.068

Cited by 16 publications

(5 citation statements)

References 38 publications

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“…Plant extracts, including polysaccharides, can relieve cellular and mitochondrial injury in the liver by restoring CPT1 activity [38][39][40] . A lower expression of AMPK leads to a higher expression of ACC, and that reduces the expression of CPT1 in T2DM [41][42] . This reduces fatty acid β-oxidation in the mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Wang,

Xiu,

Han

et al. 2024

Food Science and Human Wellness

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Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by a glycolipid metabolism disorder and islet β-cell dysfunction. SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob, an agricultural byproduct. The hypoglycemic effects of SCP-80-I on T2DM mice and its mechanisms were investigated in this study. SCP-80-I was found to signifi cantly reduce blood glucose and lipid deposition levels in T2DM mice, as well as decrease serum leptin and increase adiponectin secretion. Interestingly, real time-polymerase chain reaction (RT-PCR) and Western blotting results revealed that SCP-80-I could regulate the expression of several glycolipid metabolisms and insulin secretion genes and proteins, including 5'-AMP-activated protein kinase (AM PK), carnitine palmitoyltransferase I (CPT1), and acetyl coenzyme A carboxylase (ACC) in the liver and AMPK, sirtuin 1 (Sirt1), peroxisome proliferator-activated receptorycoactivator-1 (PGC-1α), and uncoupling protein 2 (UCP2) in the pancreas. To have a hypoglycemic effect, SCP-80-I regulated glycolipid metabolism and islet cell function in the liver by regulating the AMPK/ACC/CPT1 signaling pathway and the AMPK/Sirt1/PGC-1α and AMPK/Sirt1/UCP2 signaling pathways. These fi ndings improve our understanding of polysaccharides derived from sweet corncob and the use of SCP-80-I in the production of hypoglycemic foods.

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Wang,

Xiu,

Han

et al. 2024

Food Science and Human Wellness

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“…These beneficial effects are mediated by the activation of AMP-activated protein kinase (AMPK) signaling by PGGS. In view of these findings, the marine-derived PGGS merits further investigation as a novel agent for the prevention and treatment of liver-related hyperlipidemic diseases [132]. It has been also shown that amidated alginate can significantly decrease serum cholesterol, serum TG, hepatic cholesterol, and total hepatic lipids levels.…”

Section: Hypolipidemic Effectmentioning

confidence: 95%

Advances in Research on the Bioactivity of Alginate Oligosaccharides

et al. 2020

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Alginate is a natural polysaccharide present in various marine brown seaweeds. Alginate oligosaccharide (AOS) is a degradation product of alginate, which has received increasing attention due to its low molecular weight and promising biological activity. The wide-ranging biological activity of AOS is closely related to the diversity of their structures. AOS with a specific structure and distinct applications can be obtained by different methods of alginate degradation. This review focuses on recent advances in the biological activity of alginate and its derivatives, including their anti-tumor, anti-oxidative, immunoregulatory, anti-inflammatory, neuroprotective, antibacterial, hypolipidemic, antihypertensive, and hypoglycemic properties, as well as the ability to suppress obesity and promote cell proliferation and regulate plant growth. We hope that this review will provide theoretical basis and inspiration for the high-value research developments and utilization of AOS-related products.2 of 26 the 4 C 1 conformation and are linked by β-1,4-glycosidic bond, while in pG, all G residues are in the 1 C 4 conformation and are linked by an α-1,4-glycosidic bond. These features are responsible for the differences in their higher-order structure. For example, pG exhibits an egg-box-like conformation and usually forms stiffer 2-fold screw helical chains when dissolved in water, while pM forms belt chains through intra-molecular hydrogen bonds. Due to these dissimilarities, pM and pG, as well as their derivatives, will exhibit different activities [12].As the most abundant marine biomass and low-cost material, alginate has been extensively used in the food and medical industries. The widespread utilization is also driven by its favorable chemical properties and versatile activities. However, the applications of alginate have been greatly limited due to its high molecular weight and low bioavailability. Therefore, the degradation of high molecular weight polysaccharides into low molecular weight poly-or oligosaccharides is considered of great significance for improving their bioavailability, increasing the body's absorption of drugs, and fully utilizing the efficacy of polysaccharides. Recently, the degradation products of alginate, i.e., alginate oligosaccharides (AOS), have attracted increasing attention due to their biological activities and excellent solubility in water [13]. AOS can be depolymerized by different degradation methods, including enzymatic degradation, acid hydrolysis, and oxidative degradation [14]. Alginate lyases have been isolated from a wide range of organisms, including algae, marine invertebrates, and marine and terrestrial microorganisms, which can degrade alginate into unsaturated oligosaccharides by β-elimination [15,16]. Moreover, due to differences in degradation patterns, G content (G/M ratio), molecular weight, and spatial conformation of degradation products, AOS possess a variety of biological activities. They have anti-tumor properties [17], counteract oxidation [8], regulate immune respo...

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“…PGA sodium sulfate, the first oral heparinoid approved by Chinese FDA in 1987 (Zeng et al., 2016), has been clinically used to prevent and treat hyperlipidemia and cardio‐cerebrovascular disease (Lin et al., 2007). Propylene glycol guluronate sulfate derived from alginate effectively decreases the lipid accumulation, TC and TG contents in palmitate‐treated HepG2 cells by activating AMP‐activated protein kinase (AMPK) signaling pathway (Xin et al., 2018). The amidated alginate grafting octadecylamine had significantly higher efficacy in reducing serum and hepatic cholesterol, serum TG, and total hepatic lipids than the original alginate in rats (Marounek et al., 2017).…”

Section: Biological Properties Structure‐activity Relationship and Un...mentioning

confidence: 99%

Chemically modified seaweed polysaccharides: Improved functional and biological properties and prospective in food applications

Zhou,

2024

Comp Rev Food Sci Food Safe

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Seaweed polysaccharides are natural biomacromolecules with unique physicochemical properties (e.g., good gelling, emulsifying, and film‐forming properties) and diverse biological activities (e.g., anticoagulant, antioxidant, immunoregulatory, and antitumor effects). Furthermore, they are nontoxic, biocompatible and biodegradable, and abundant in resources. Therefore, they have been widely utilized in food, cosmetics, and pharmaceutical industries. However, their properties and bioactivities sometimes are not satisfactory for some purposes. Modification of polysaccharides can impart the amphiphilicity and new functions to the biopolymers and change the structure and conformation, thus effectively improving their functional properties and biological activities so as to meet the requirement for targeted applications. This review outlined the modification methods of representative red algae polysaccharides (carrageenan and agar), brown algae polysaccharides (fucoidan, alginate, and laminaran), and green algae polysaccharides (ulvan) that have potential food applications, including etherification, esterification, degradation, sulfation, phosphorylation, selenylation, and so on. The improved functional properties and bioactivities of the modified seaweed polysaccharides and their potential food applications are also summarized.

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Propylene glycol guluronate sulfate (PGGS) reduces lipid accumulation via AMP-activated kinase activation in palmitate-induced HepG2 cells

Cited by 16 publications

References 38 publications

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Advances in Research on the Bioactivity of Alginate Oligosaccharides

Chemically modified seaweed polysaccharides: Improved functional and biological properties and prospective in food applications

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