Pros-IT CNR: an Italian prostate cancer monitoring project

Noale, Marianna; Maggi, Stefania; Artibani, Walter; Bassi, Pier Francesco; Bertoni, F.; Bracarda, Sergio; Conti, Giario; Corvò, Renzo; Gacci, Mauro; Graziotti, P.; Magrini, Stefano Maria; Enrici, Riccardo Maurizi; Mirone, Vincenzo; Montironi, Rodolfo; Muto, Giovanni; Pecoraro, Stefano; Porreca, Angelo; Ricardi, Umberto; Tubaro, Andrea; Zagonel, Vittorina; Zattoni, Filiberto; Crepaldi, Gaetano; Alitto, A.R.; Ambrosi, E.; Antonelli, Alessandro; Aristei, Cynthia; Barbieri, Michele; Bardari, F.; Bardoscia, Lilia; Barra, Salvina; Bartoncini, Sara; Basso, Umberto; Becherini, Carlotta; Bellavita, Rita; Bergamaschi, F.; Berlingheri, S.; Berruti, Alfredo; Borghesi, Marco; Bortolus, Roberto; Borzillo, Valentina; Bosetti, D.; Bove, Giuseppe; Bove, Pierluigi; Brausi, Maurizio; Bruni, Alessio; Bruno, Giorgio; Brunocilla, Eugenio; Buffoli, Alberto; Buglione, Michela; Buttigliero, Consuelo; Cacciamani, Giovanni; Caldiroli, M.; Cardo, Giuseppe; Carmignani, G.; Carrieri, Giuseppe; Castelli, Emanuele; Castrezzati, E.; Catalano, Gianpiero; Cattarino, Susanna; Catucci, Francesco; Francolini, Dario Cavallini; Ceccarini, O.; Celia, Antonio; Chiancone, Francesco; Chini, T.; Cianci, C.; Cisternino, A; Collura, Devis; Corbella, Franco; Corinti, Matteo; Corsi, Paolo; Cortese, F.; Corti, L.; Nunzio, Cosimo De; Cristiano, O.; D’Angelillo, Rolando Maria; Pozzo, L. Da; D’Agostino, Daniele; D’Andrea, David; Dandrea, Matteo; Angelis, Michele De; Cobelli, Ottavio De; Concilio, Bernardino De; Lisa, Antonello De; Luca, Stefano De; Stefani, Agostina De; Deantoni, C.L.; Esposti, C. Degli; Destito, Anna; Detti, Beatrice; Muzio, N. Di; Stasio, A. Di; Stefano, C. Di; Trapani, D. Di; Difino, Giuseppe; Falivene, Sara; Farullo, Giuseppe; Fedelini, Paolo; Ferrari, Ilaria; Ferraú, Francesco; Ferro, Matteo; Fodor, Andrei; Fontana, Francesco; Francesca, F.; Francolini, Giulio; Frata, Paolo; Frezza, G.; Gabriele, P.; Galeandro, M.; Garibaldi, E.; Gennari, Pietro Giovanni; Gentilucci, Alessandro; Giacobbe, Alessandro; Giussani, Laura; Giusti, G.; Gontero, Paolo; Guarneri, Alessia; Guida, Cesare; Gurioli, Alberto; Huqi, Dorijan; Imbimbo, Ciro; Ingrosso, Gianluca; Iotti, C.; Italia, C.; Mattina, Pierdaniele La; Lamanna, E.; Lastrucci, Luciana; Lazzari, Grazia; Liberale, F.; Liguori, Giovanni; Lisi, Roberto; Lohr, Frank; Lombardo, Riccardo; Lovisolo, J.; Ludovico, Giuseppe Mario; Macchione, Nicola; Maggio, Francesca; Malizia, Michele; Manasse, Gianluca Carlo; Mandoliti, Giovanni; Mantini, Giovanna; Marafioti, L.; Marciello, L.; Marconi, A; Martillotta, Antonietta; Marzano, S.; Masciullo, S.; Maso, G.; Massenzo, A.; Mazzeo, E.; Mearini, Luigi; Medoro, S.; Mole, R.; Monesi, G.; Montanari, Emanuele; Montefiore, F.; Montesi, Giampaolo; Morgia, Giuseppe; Moro, G.; Muscas, Giorgio; Musio, Daniela; Muto, Paolo; Muzzonigro, Giovanni; Napodano, G.; Negro, C.; Nidini, Mattia; Ntreta, M.; Orsatti, M.; Palazzolo, Carmela; Palumbo, Isabella; Parisi, Alessandro; Parma, P.; Pavan, Nicola; Pericolini, Martina; Pinto, Francesco; Pistone, Antonio; Pizzuti, V.; Platania, A; Polli, Caterina; Pomara, Giorgio; Ponti, Elisabetta; Porcaro, Antonio Benito; Porpiglia, Francesco; Pugliese, Dario; Pycha, Armin; Raguso, Giuseppe; Rampini, Andrea; Randone, D. F.; Roscigno, Marco; Ruggieri, Maria Paola; Ruoppo, G.; Sanseverino, R.; Santacaterina, Anna; Santarsieri, Michele; Santoni, R.; Scagliarini, Sarah; Scagliotti, Giorgio Vittorio; Scanzi, M.; Scarcia, Marcello; Schiavina, Riccardo; Sciarra, Alessandro; Sciorio, Carmine; Scolaro, Tindaro; Scuzzarella, Salvatore; Selvaggio, Oscar; Serao, A.; Serni, Sergio; Signor, M.; Silvani, Mauro; Silvano, Giovanni; Silvestris, Franco; Simeone, Claudio; Simone, Valeria De; Spagnoletti, Girolamo; Spinelli, Matteo; Squillace, Luigi; Tombolini, Vincenzo; Toninelli, Mariastella; Triggiani, Luca; Trinchieri, Alberto; Trodella, L.; Trodella, Lucio; Trombetta, Carlo; Tronnolone, Lidia; Tucci, Marco; Urzì, Daniele; Valdagni, Riccardo; Valeriani, Maurizio; Vanoli, Maurizio; Vitali, Ettore; Zaramella, S.; Zeccolini, Guglielmo; Zini, G.

doi:10.1007/s40520-017-0735-6

Cited by 34 publications

(24 citation statements)

References 11 publications

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“…The Pros-IT CNR study design has been described elsewhere [ 8 ]. Briefly, the Pros-IT CNR is a multicenter, prospective study that aims to monitor the quality of life of a sample of Italian male patients 18 years and older who were diagnosed with biopsy-verified treatment-naïve prostate cancer after September 1, 2014.…”

Section: Methodsmentioning

confidence: 99%

Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study

Porreca

Noale

Artibani

et al. 2018

Health Qual Life Outcomes

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BackgroundThe National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed.MethodsOne thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12).ResultsAt diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one.Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis.ConclusionsData collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.

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Section: Methodsmentioning

confidence: 99%

Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study

Porreca

Noale

Artibani

et al. 2018

Health Qual Life Outcomes

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“…The Swedish Laparoscopic Prostatectomy Robot Open study [12,13] reported no differences in continence and sexual function for [14] reported no differences in urinary and sexual functions assessed at 12 months by the EPIC-26 questionnaire through phone interview on 2002 cases (1117 ORP, 885 RARP) treated in the period 2009-2012. Finally, a Korean study [15] at 7 academic centres with high-volume surgeons recruited 258 patients (41 ORP, 63 LRP, 105 RARP) from October 2014 to December 2015 and found a better recovery of sexual functions in the RARP and LRP groups, as measured by the EORTC QLQ-C30 questionnaire.…”

Section: Radical Prostatectomy In Pros-it Cnr Studymentioning

confidence: 99%

“…Such studies are potentially able to account for selection bias and provide more reproducible results [9]. Up to now, 6 populationbased projects [10][11][12][13][14][15] assessed the impact of surgical approach on perceptions of urinary, bowel, and sexual function and of general health-related quality of life (HRQoL) by validated patient-reported outcome measures (PROMs). However, these studies are not devoid of flaws, since they relied on long time span, generally including the learning phase of minimally invasive approaches.…”

Section: Introductionmentioning

confidence: 99%

Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

et al. 2019

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Background: To report health-related quality of life outcomes as assessed by validated patient-reported outcome measures (PROMs) after radical prostatectomy (RP). Methods: This study analyzed patients treated with RP within The PROState cancer monitoring in Italy, from the National Research Council (Pros-IT CNR). Italian versions of Short-Form Heath Survey and university of California los Angeles-prostate cancer index questionnaires were administered. PROMs were physical composite scores, mental composite scores and urinary, bowel, sexual functions and bothers (UF/B, BF/B, SF/B). Baseline unbalances were controlled with propensity scores and stabilized inverse weights; differences in PROMs between different RP approaches were estimated by mixed models. Results: Of 541 patients treated with RP, 115 (21%) received open RP (ORP), 90 (17%) laparoscopic RP (LRP) and 336 (61%) robot-assisted RP (RARP). At head-to-head comparisons, RARP showed higher 12-month UF vs. LRP (interaction treatment * time p = 0.03) and 6-month SF vs. ORP (p < 0.001). At 12-month from surgery, 67, 73 and 79% of patients used no pad for urinary loss in ORP, LRP and RARP respectively (no differences for each comparison). Conversely, 16, 27 and 40% of patients declared erections firm enough for sexual intercourse in ORP, LRP and RARP respectively (only significant difference for ORP vs. RARP, p = 0.0004). Conclusions: Different RP approaches lead to significant variations in urinary and sexual PROMs, with a general trend in favour of RARP. However, their clinical significance seems limited.

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“…A 44-year-old man received a kidney transplant from a braindead donor (DBD). The donor was 59 years old, had died from cerebral hemorrhage, his Kidney Donor Profile Index (KDPI) was 83%, Karpinsky's score was 3, and he had been a smoker with a past history of prostate cancer for which he was in regular follow-up (19). The surgeon described atheromatous plaques in the renal artery that were particularly evident at the confluence with the aorta and were partially removed before implantation.…”

Section: Case Report Casementioning

confidence: 99%

Iloprost in Acute Post-kidney Transplant Atheroembolism: A Case Report of Two Successful Treatments

et al. 2020

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Cholesterol embolization (CE) is a rare and alarming post-transplant complication, responsible for primary non-function (PNF) or delayed graft function (DGF). Its incidence is expected to rise due to increasingly old donors and recipients and the extended criteria for donation. Therapy with statins and steroids has not been shown to be effective, while agonism of prostaglandin I 2 has been reported to be useful in systemic CE. We report two cases of acute post-transplant CE in which intravenous iloprost (0.05 mg/kg/day) was added to standard statin and steroid therapy. In the first instance, CE was due to embolization from the kidney artery resulting in embolization of the small vessels; after a long DGF and 15 days of iloprost therapy, renal function recovered. The second instance is a case of embolization from the iliac artery of the recipient, where CE manifested as a partial renal infarction. After 5 days of iloprost administration, creatinine levels improved. Iloprost acts on vasodilation and on different inflammatory pathways, improving the anti-inflammatory profile. Post-transplant CE is difficult to diagnose and, if not treated, can lead to loss of function. Iloprost added to standard therapy could be beneficial in accelerating renal function recovery immediately after transplant.

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Pros-IT CNR: an Italian prostate cancer monitoring project

Abstract: The study will provide information on patients' quality of life and its variations over time in relation to the treatments received for the prostate cancer.

Cited by 34 publications

References 11 publications

Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study

Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: the Pros-IT CNR study

Impact of Surgical Approach on Patient-Reported Outcomes after Radical Prostatectomy: A Propensity Score-Weighted Analysis from a Multicenter, Prospective, Observational Study (The Pros-IT CNR Study)

Iloprost in Acute Post-kidney Transplant Atheroembolism: A Case Report of Two Successful Treatments

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