Young children's prosodic fluency correlates with their reading ability, as children who are better early readers also produce more adult-like prosodic cues to syntactic and semantic structure. But less work has explored this question for high school readers, who are more proficient readers, but still exhibit wide variability in reading comprehension skill and prosodic fluency. In the current study, we investigated acoustic indices of prosodic production in high school students (N = 40; ages 13-19) exhibiting a range of reading comprehension skill. Participants read aloud a series of 12 short stories which included simple statements, wh-questions, yes-no questions, quotatives, and ambiguous and unambiguous multiclausal sentences. In addition, to assess the contribution of discourse coherence, sentences were read in either canonical or randomized order. Acoustic cues known to index prosodic phenomena-duration, fundamental frequency, and intensity-were extracted and compared across structures and participants. Results demonstrated that high school readers as a group consistently signal syntactic and semantic structure with prosody, and that reading comprehension skill, above and beyond lower-level skills, correlates with prosodic fluency, as better comprehenders produced stronger prosodic cues. However, discourse coherence did not produce consistent effects. These results strengthen the finding that prosodic fluency and reading comprehension are linked, even for older, proficient readers.