Prospecting potential of endophytes for modulation of biosynthesis of therapeutic bioactive secondary metabolites and plant growth promotion of medicinal and aromatic plants

Singh, Devendra; Thapa, Shobit; Mahawar, Himanshu; Kumar, Dharmendra; Geat, Neelam; Singh, Swati

doi:10.1007/s10482-022-01736-6

Cited by 29 publications

(17 citation statements)

References 217 publications

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“…Aromatherapy has a long history and culture in the application of folk medicine in Southeast Asia. Aromatic plant extracts have rich medicinal value and are used in medical fields such as diabetes, cardiovascular, hypertension, obesity, arthritis, cancer, and leprosy [ 16 , 35 ]. CT is a natural plant component with an aromatic scent.…”

Section: Discussionmentioning

confidence: 99%

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

et al. 2022

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In type 2 diabetes mellitus (T2DM), oxidative stress induces endothelial dysfunction (ED), which is closely related to the formation of atherosclerosis. However, there are few effective drugs to prevent and cure it. Citronellal (CT) is an aromatic active substance extracted from citronella plants. Recently, CT has been shown to prevent ED, but the underlying mechanism remains unclear. The purpose of this study was to investigate whether CT ameliorated T2DM-induced ED by inhibiting the TRPM2/NHE1 signal pathway. Transient receptor potential channel M2 (TRPM2) is a Ca2+-permeable cation channel activated by oxidative stress, which damages endothelial cell barrier function and further leads to ED or atherosclerosis in T2DM. The Na+/H+ exchanger 1 (NHE1), a transmembrane protein, also plays an important role in ED. Whether TRPM2 and NHE1 are involved in the mechanism of CT improving ED in T2DM still needs further study. Through the evaluations of ophthalmoscope, HE and Oil red staining, vascular function, oxidative stress level, and mitochondrial membrane potential evaluation, we observed that CT not only reduced the formation of lipid deposition but also inhibited ED and suppressed oxidative stress-induced mitochondrial damage in vasculature of T2DM rats. The expressions of NHE1 and TRPM2 was up-regulated in the carotid vessels of T2DM rats; NHE1 expression was also upregulated in endothelial cells with overexpression of TRPM2, but CT reversed the up-regulation of NHE1 in vivo and in vitro. In contrast, CT had no inhibitory effect on the expression of NHE1 in TRPM2 knockout mice. Our study show that CT suppressed the expression of NHE1 and TPRM2, alleviated oxidative stress-induced mitochondrial damage, and imposed a protective effect on ED in T2DM rats.

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Section: Discussionmentioning

confidence: 99%

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

et al. 2022

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“…As reliable companions of hosts, endophytes play an important role in the growth and development of hosts and the accumulation of secondary metabolites ( Singh et al, 2022 ). In recent years, with the rapid increase in endophyte-related research, endophytes have gradually become the focus of attention.…”

Section: Applications and Research Prospects Of Endophytes And Second...mentioning

confidence: 99%

“…As reliable companions of hosts, endophytes play an important role in the growth and development of hosts and the accumulation of secondary metabolites (Singh et al, 2022).…”

Section: Applications and Research Prospects Of Endophytes And Second...mentioning

confidence: 99%

Biosynthetic Mechanisms of Secondary Metabolites Promoted by the Interaction Between Endophytes and Plant Hosts

Wen

Qin

et al. 2022

Front. Microbiol.

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Endophytes is a kind of microorganism resource with great potential medicinal value. The interactions between endophytes and host not only promote the growth and development of each other but also drive the biosynthesis of many new medicinal active substances. In this review, we summarized recent reports related to the interactions between endophytes and hosts, mainly regarding the research progress of endophytes affecting the growth and development of host plants, physiological stress and the synthesis of new compounds. Then, we also discussed the positive effects of multiomics analysis on the interactions between endophytes and their hosts, as well as the application and development prospects of metabolites synthesized by symbiotic interactions. This review may provide a reference for the further development and utilization of endophytes and the study of their interactions with their hosts.

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“…To date, several reviews on plant SMs have been published [ 15 , 16 , 17 ], but there are few systematic reviews on how endophytes affect the synthesis of plant SMs [ 18 , 19 , 20 ]. In this review, we have summarized the development of endophyte–plant interactions and the molecular mechanisms of endophyte–plant SM interactions, and we have presented a platform for endophyte–plant interactions.…”

Section: Introductionmentioning

confidence: 99%

Functional Endophytes Regulating Plant Secondary Metabolism: Current Status, Prospects and Applications

Xiong

Wen

et al. 2023

IJMS

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Endophytes, which are widely found in host plants and have no harmful effects, are a vital biological resource. Plant endophytes promote plant growth and enhance plants’ resistance to diseases, pests, and environmental stresses. In addition, they enhance the synthesis of important secondary metabolites in plants and improve the potential applicability of plants in agriculture, medicine, food, and horticulture. In this review, we summarize the recent progress in understanding the interaction between endophytes and plants and summarize the construction of synthetic microbial communities (SynComs) and metaomics analysis of the interaction between endophytes and plants. The application and development prospects of endophytes in agriculture, medicine, and other industries are also discussed to provide a reference for further study of the interaction between endophytes and plants and further development and utilization of endophytes.

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Prospecting potential of endophytes for modulation of biosynthesis of therapeutic bioactive secondary metabolites and plant growth promotion of medicinal and aromatic plants

Cited by 29 publications

References 217 publications

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

Biosynthetic Mechanisms of Secondary Metabolites Promoted by the Interaction Between Endophytes and Plant Hosts

Functional Endophytes Regulating Plant Secondary Metabolism: Current Status, Prospects and Applications

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