Prospection of chitosan and its derivatives in wound healing: Proof of patent analysis (2010–2020)

Shivakumar, P.; Gupta, Maram Suresh; Jayakumar, R.; Gowda, Devegowda Vishakante

doi:10.1016/j.ijbiomac.2021.06.086

Cited by 53 publications

(34 citation statements)

References 69 publications

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“…In such cases, chitosan-coated nanocapsules may represent a superior delivery platform. Additionally, as previously described, chitosan presents welldescribed relevant properties to wound healing [44,45]. Besides being biodegradable and biocompatible, chitosan presents a moderate antimicrobial activity and positively influences the re-epithelialization and regeneration of the granular layer of wounds [17].…”

Section: Skin Penetrationmentioning

confidence: 80%

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

et al. 2022

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Scarless skin regeneration is a challenge in regenerative medicine. Herein, we explore the regenerative potential of a Cupuaçu seed extract (Theobroma grandiflorum) to develop an innovative skin regeneration formulation based on chitosan-coated nanocapsules. Cupuaçu seed extract significantly stimulated cell proliferation and migration. A reparative gene expression profile could be verified following extract treatment, which included high levels of MKI67, a cellular proliferation marker, and extracellular matrix genes, such as ELN and HAS2, which code for elastin and hyaluronic acid synthase 2. Formulations with Cupuaçu seed extract successfully entrapped into nanocapsules (EE% > 94%) were developed. Uncoated or coated nanocapsules with low-molecular-weight chitosan presented unimodal size distribution with hydrodynamic diameters of 278.3 ± 5.0 nm (PDI = 0.18 ± 0.02) and 337.2 ± 2.1 nm (PDI = 0.27 ± 0.01), respectively. Both nanosystems were physically stable for at least 120 days and showed to be non-irritating to reconstructed human epidermis. Chitosan coating promoted active penetration into undamaged skin areas, which were still covered by the stratum corneum. In conclusion, the present study demonstrated for the first time the biotechnological potential of the frequently discarded Cupuaçu seed as a valuable pharmaceutical ingredient to be used in regenerative skin products.

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Section: Skin Penetrationmentioning

confidence: 80%

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

et al. 2022

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“…CTN pharmaceutical and medical applications have demonstrated its pharmacological and physiological roles, including its antioxidant, anti-inflammatory, antimicrobial, and wound healing efficacy [ 7 , 201 , 202 , 203 , 204 , 205 , 206 ]. Its potency in fostering chronic wound healing has been explored in various forms, including as powders, hydrogels, sponges, nanoparticles, bandages, and films [ 7 , 206 ].…”

Section: Natural and Semi-synthetic Compounds For Wound Healingmentioning

confidence: 99%

“…In another study by Marangon et al, it was further established that the incorporation of CTN with rhamnolipid not only improved the antibacterial activity of the antibiotic agent against diverse strains of Staphylococcus , but also stabilised the CTN, showing the effective synergy between the two molecules [ 202 ]. Furthermore, studies by several authors have demonstrated the effectiveness of CTN in promoting tissue remodelling, with a reduction of scar tissue and an increase in the wound healing efficacy [ 7 , 203 , 204 , 205 , 206 , 210 , 211 ]. This is evidenced by a study conducted by Baxter and co-workers, in which a chitosan dressing was applied to a third-degree burn (mice model) leading to wound contraction [ 203 ].…”

Section: Natural and Semi-synthetic Compounds For Wound Healingmentioning

confidence: 99%

Antibiotics-Free Compounds for Chronic Wound Healing

2022

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The rapid rise in the health burden associated with chronic wounds is of great concern to policymakers, academia, and industry. This could be attributed to the devastating implications of this condition, and specifically, chronic wounds which have been linked to invasive microbial infections affecting patients’ quality of life. Unfortunately, antibiotics are not always helpful due to their poor penetration of bacterial biofilms and the emergence of antimicrobial resistance. Hence, there is an urgent need to explore antibiotics-free compounds/formulations with proven or potential antimicrobial, anti-inflammatory, antioxidant, and wound healing efficacy. The mechanism of antibiotics-free compounds is thought to include the disruption of the bacteria cell structure, preventing cell division, membrane porins, motility, and the formation of a biofilm. Furthermore, some of these compounds foster tissue regeneration by modulating growth factor expression. In this review article, the focus is placed on a number of non-antibiotic compounds possessing some of the aforementioned pharmacological and physiological activities. Specific interest is given to Aloe vera, curcumin, cinnamaldehyde, polyhexanide, retinoids, ascorbate, tocochromanols, and chitosan. These compounds (when alone or in formulation with other biologically active molecules) could be a dependable alternative in the management or prevention of chronic wounds.

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“…Moreover, these and other data, including the possibility of binding growth factors required for wound healing and bone regeneration, indicate the potential of chitosan-based grafts and nanoparticles for delivery of drugs and oligonucleotides (siRNA, etc.) for other biomedical applications [ 52 , 64 , 67 , 68 , 69 , 70 ].…”

Section: Chitin/chitosan Matrices Provide the Potential For Multiple ...mentioning

confidence: 99%

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

Behr

Ganesan

2022

Materials

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Improved wound healing of burnt skin and skin lesions, as well as medical implants and replacement products, requires the support of synthetical matrices. Yet, producing synthetic biocompatible matrices that exhibit specialized flexibility, stability, and biodegradability is challenging. Synthetic chitin/chitosan matrices may provide the desired advantages for producing specialized grafts but must be modified to improve their properties. Synthetic chitin/chitosan hydrogel and aerogel techniques provide the advantages for improvement with a bioinspired view adapted from the natural molecular toolbox. To this end, animal genetics provide deep knowledge into which molecular key factors decisively influence the properties of natural chitin matrices. The genetically identified proteins and enzymes control chitin matrix assembly, architecture, and degradation. Combining synthetic chitin matrices with critical biological factors may point to the future direction with engineering materials of specific properties for biomedical applications such as burned skin or skin blistering and extensive lesions due to genetic diseases.

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Prospection of chitosan and its derivatives in wound healing: Proof of patent analysis (2010–2020)

Cited by 53 publications

References 69 publications

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

Skin Regenerative Potential of Cupuaçu Seed Extract (Theobroma grandiflorum), a Native Fruit from the Amazon: Development of a Topical Formulation Based on Chitosan-Coated Nanocapsules

Antibiotics-Free Compounds for Chronic Wound Healing

Improving Polysaccharide-Based Chitin/Chitosan-Aerogel Materials by Learning from Genetics and Molecular Biology

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