Prospective Analysis of Factors Related to Migraine Aura – The PAMINA Study

Salhofer‐Polanyi, Sabine; Frantal, Sophie; Brannath, Werner; Seidel, Stefan; Wöber‐Bingöl, Çiçek; Wöber, Christian

doi:10.1111/j.1526-4610.2012.02166.x

Cited by 17 publications

(14 citation statements)

References 33 publications

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“…In a small percentage of patients reporting to be sensitive to red wine or vodka, attacks are triggered consistently. This triggering inconsistency is also seen in most of the prospective studies . We hypothesize that low consistency does not contradict the potential triggering effect of alcoholic beverages because the triggering potential depends on the susceptibility status of the patient to have an attack.…”

Section: Discussionmentioning

confidence: 81%

Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine

Onderwater

Oosterhout

Schoonman

et al. 2018

Euro J of Neurology

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Background and purpose Alcoholic beverages are frequently reported migraine triggers. We aimed to assess self‐reported alcohol consumption as a migraine attack trigger and to investigate the effect on alcohol consumption behavior in a large migraine cohort. Methods We conducted a cross‐sectional, web‐based, questionnaire study among 2197 patients with migraine from the well‐defined Leiden University MIgraine Neuro‐Analysis (LUMINA) study population. We assessed alcoholic beverage consumption and self‐reported trigger potential, reasons behind alcohol abstinence and time between alcohol consumption and migraine attack onset. Results Alcoholic beverages were reported as a trigger by 35.6% of participants with migraine. In addition, over 25% of patients with migraine who had stopped consuming or never consumed alcoholic beverages did so because of presumed trigger effects. Wine, especially red wine (77.8% of participants), was recognized as the most common trigger among the alcoholic beverages. However, red wine consistently led to an attack in only 8.8% of participants. Time of onset was rapid (<3 h) in one‐third of patients and almost 90% had an onset <10 h independent of beverage type. Conclusions Alcoholic beverages, especially red wine, are recognized as a migraine trigger factor by patients with migraine and have a substantial effect on alcohol consumption behavior. Rapid onset of provoked migraine attacks in contrast to what is known about hangover headache might point to a different mechanism. The low consistency of provocation suggests that alcoholic beverages acting as a singular trigger is insufficient and may depend on a fluctuating trigger threshold.

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Section: Discussionmentioning

confidence: 81%

Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine

Onderwater

Oosterhout

Schoonman

et al. 2018

Euro J of Neurology

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“…In one population-based study, over half of women with migraine reported an increased rate of migraine related to menses, although only a small minority (3.9%) had migraine during menstruation (62). Diary studies confirm that menstruation can trigger migraine, perhaps more so in those with aura (63). Migraine attacks during menses may be more severe, with reduced response to acute medication such as triptans (64).…”

Section: Menstrual Changes As a Migraine Triggermentioning

confidence: 99%

Triggers, Protectors, and Predictors in Episodic Migraine

Marmura

2018

Curr Pain Headache Rep

139

103

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“…A total of 327 migraine patients completed up to a 90‐day diary in the Prospective Analysis of Migraine Attacks Study (PAMINA) study with further analysis if one migraine with aura was recorded. There were 54 patients who suffered 354 days with migraine aura, with smoking showing the most striking difference, increasing the risk of aura (multivariate OR 2.29, 95% CI 1.48‐3.54, P < .0002), but decreasing the risk of headaches and migraine without aura (multivariate OR 0.46, 95% CI 0.25‐0.85) …”

Section: Conflicting Inadequate or Equivocal Smoking Studiesmentioning

confidence: 99%

“…There were 54 patients who suffered 354 days with migraine aura, with smoking showing the most striking difference, increasing the risk of aura (multivariate OR 2.29, 95% CI 1.48-3.54, P < .0002), but decreasing the risk of headaches and migraine without aura (multivariate OR 0.46, 95% CI 0.25-0.85). 98 A case-control and prevalence study performed in 2000 assessed 245 female students with migraine from the Faculty of Medicine and Faculty of Pharmacy, University of Belgrade (Serbia) and compared lifestyles including smoking in those with and without a family history of migraine (same database as Vlajinac 2003 74 ). A total of 132/245 (53.9%) had a positive family history of migraine with more severe headaches and significantly more menstrual migraine than migraineurs without a family history.…”

Section: Conflicting Inadequate or Equivocal Smoking Studiesmentioning

confidence: 99%

Tobacco, Nicotine, and Headache

Taylor

2015

Headache

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Conflicting data support the validity of patient-reported environmental tobacco exposure as a headache trigger. Prospective controlled studies are needed, but unlikely to be performed, to determine the extent that tobacco influences the headache process, in addition to other under-recognized factors. Meanwhile, because of numerous other negative health effects, decreased tobacco exposure should be recommended to headache patients of all ages in hopes of decreasing disability and improving functionality.

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Prospective Analysis of Factors Related to Migraine Aura – The PAMINA Study

Abstract: Menstruation is the most prominent factor increasing the risk of aura as well as that of HoA and MoA. Smoking shows the most striking difference increasing the risk of aura, but decreasing the risk of HoA and MoA.

Cited by 17 publications

References 33 publications

Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine

Alcoholic beverages as trigger factor and the effect on alcohol consumption behavior in patients with migraine

Triggers, Protectors, and Predictors in Episodic Migraine

Tobacco, Nicotine, and Headache

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