Prospective Analysis of Health-Related Quality of Life in Older Adults With Cancer

Ximenes, Coeli Regina; Bergmann, Anke; Lima, Jurema Telles de Oliveira; Lima, Wigna Rayssa Pereira; Britto, Murilo; Mello, Maria Júlia Gonçalves de; Thuler, Luiz Cláudio Santos

doi:10.1177/2374373519889246

Cited by 2 publications

(2 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding is in agreement with other studies which reported a significantly impaired HRQoL among esophageal cancer patients 21,30–33 . Various studies reported that older, co‐morbid, and advanced‐stage cancer patients had poor HRQoL 15,34–37 . Hence, this high burden of poor HRQoL revealed in our study could be linked to the predominance of co‐morbid and advanced‐stage esophageal cancer patients in our setting.…”

Section: Discussionsupporting

confidence: 93%

“…21,[30][31][32][33] Various studies reported that older, co-morbid, and advanced-stage cancer patients had poor HRQoL. 15,[34][35][36][37] Hence, this high burden of poor HRQoL revealed in our study could be linked to the predominance of co-morbid and advanced-stage esophageal cancer patients in our setting. In sub-Saharan Africa, cancer care is suboptimal due to the shortage of diagnostic facilities and the high cost of treatment.…”

Section: Determinants Of Hrqol Among Gastrointestinal Cancer Patientsmentioning

confidence: 54%

See 1 more Smart Citation

Health‐related quality of life among patients with esophageal, gastric, and colorectal cancer at Kenyatta National Hospital

Degu,

Karimi,

Opanga

et al. 2024

Cancer Reports

View full text Add to dashboard Cite

BackgroundDespite the advancement of modern treatment approaches, several studies indicated a diminished health‐related quality of life (HRQoL) in patients with gastrointestinal cancer. However, there is insufficient data about the HRQoL of gastrointestinal cancer patients in Kenya.AimsThe study aimed to investigate HRQoL and its determinants in gastrointestinal cancer patients at Kenyatta National Hospital.MethodsA cross‐sectional study was employed among 160 esophageal, 103 gastric, and 96 colorectal cancer patients. The patient list, identified by unique hospital identification numbers, was obtained from records. Eligibility was assessed based on predetermined criteria, and the hospital identification numbers were reshuffled. Study participants were then randomly selected daily during the data collection period. Data were collected using a researcher‐administered European Organization for Research and Treatment of Cancer quality of life questionnaire. The data entry and analysis were carried out using Statistical Package for the Social Sciences 26.0 statistical software. A bivariate and multivariate binary logistic regression analysis was employed to investigate determinants of HRQoL at a 0.05 level of significance.ResultsMost esophageal (N = 118, 73.7%), gastric (N = 75, 72.8%), and colorectal (N = 72, 75%) cancer patients had poor overall HRQoL. In the social (p = .04) and cognitive (p = .02) domain of HRQoL, esophageal cancer patients had a significantly lower mean score as compared to gastric cancer patients. Colorectal cancer patients had the highest mean score in physical functioning (p = .01) as compared with gastric cancer patients. Nonetheless, gastric cancer patients had the highest mean score in emotional functioning domains of quality of life as compared to esophageal (p = .04) and colorectal (p < .001) cancer patients The study revealed a low mean HRQoL score in the majority of the symptom domains of quality of life. A statistically significant difference in all domains of HRQoL was not observed in various treatment modalities of gastrointestinal cancer. Advanced‐stage (stages III and IV) and co‐morbidities were significant determinants of poor HRQoL.ConclusionsThe overall HRQoL of gastrointestinal cancer patients was poor. Advanced‐stage cancer and co‐morbidities were significant determinants of poor HRQoL. Therefore, intensification of routine monitoring of the disease and the treatments should be actively implemented to improve the HRQoL.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Determinants Of Hrqol Among Gastrointestinal Cancer Patientsmentioning

confidence: 54%

Health‐related quality of life among patients with esophageal, gastric, and colorectal cancer at Kenyatta National Hospital

Degu,

Karimi,

Opanga

et al. 2024

Cancer Reports

View full text Add to dashboard Cite

show abstract

Health-related quality of life in treatment-naive, older patients with cancer from India: A prospective observational study

Soni,

Banerjee,

Saravanan

et al. 2022

Cancer Research, Statistics, and Treatment

View full text Add to dashboard Cite

Background: Health-related quality of life (HRQoL) is a major concern for older patients with cancer. The goal of cancer care in most older patients is maintaining the quality of the remaining years of life rather than prolonging survival. Objectives: We aimed to evaluate the quality-of-life (QoL) domains in treatment-naïve older patients with cancer. Materials and Methods: This cross-sectional observational study was done in the Outpatient Department of Geriatric Medicine of the All India Institute of Medical Science, New Delhi, India from July 2015 to June 2017. Treatment-naïve patients aged 60 years and above with a histological diagnosis of malignancy were enrolled. The QoL questions were asked in Hindi/English (as per the patient’s comfort) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ- C30). The scores on the different domains of the QoL were noted; scoring was as per the EORTC QLQ-C30 scoring manual. Continuous scores were converted into dichotomous variables by using a cut-off of 50, i.e. scores less than 50 were graded as “low scores” while scores of 50 and above were graded as “high scores.” Results: Out of the total of 419 questionnaires obtained, 360 were analyzed. Fatigue was reported in 248 (68.9%) patients, loss of appetite in 239 (66.4%), and pain in 180 (50%). Poor functioning (score <50) was seen in 238 (66%) patients in the global QoL domain (overall health and quality of life in the preceding one week), in 248 (68.9%) in the role functioning domain, in 200 (55.5%) in the physical functioning domain, and in 268 (74.3%) in the emotional functioning domain. Financial constraints were reported by 239 (66.4%) patients. Conclusion: In older patients with cancer, fatigue, loss of appetite, and pain were the predominant symptoms affecting QoL. Poorer scores were reported in the global health status domain, financial difficulties, and the domains of physical, role, and emotional functioning. These results can help in planning early interventions, targeted at improving the QoL in these patients.

show abstract

Prospective Analysis of Health-Related Quality of Life in Older Adults With Cancer

Cited by 2 publications

References 28 publications

Health‐related quality of life among patients with esophageal, gastric, and colorectal cancer at Kenyatta National Hospital

Health‐related quality of life among patients with esophageal, gastric, and colorectal cancer at Kenyatta National Hospital

Health-related quality of life in treatment-naive, older patients with cancer from India: A prospective observational study

Contact Info

Product

Resources

About