Prospective analysis of sensitivity and specificity of urinary cytology and other urinary biomarkers for bladder cancer

Circulating miRNA panels for specific and early detection in bladder cancer

“…Compared with typical urine tumor biomarkers, such as the Nuclear Matrix Protein 22 (NMP22) and BTA stat test, our model had much higher sensitivity and specificity . In the training and validation sets, the 7‐miRNA panel in bladder cancer showed high sensitivity (95%‐98%) and specificity (87%‐91%), whereas another typical tumor detection method, urinary cytology, which is also a low‐invasiveness test, had 48% sensitivity and 86% specificity . Notably, the 7‐miRNA panel in bladder cancer is also effective for the detection of both low and high grades (92.7% and 96.1% in sensitivity, respectively), suggesting that the performance of the 7‐miRNA panel is independent of tumor grade.…”

EAU Guidelines on Non–Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016

“…The examination of voided urine or bladder-washing specimens for exfoliated cancer cells has high sensitivity in HG tumours (84%) but low sensitivity in low-grade (LG) tumours (16%) [22]. The sensitivity for CIS detection is 28-100% [23] (LE: 2b).…”

An up-to-date catalog of available urinary biomarkers for the surveillance of non-muscle invasive bladder cancer

“…According to a phased approach, NMP22 tests reached phase III (independent confirmation studies). Recently, four marker-comparison studies have been published, reporting low sensitivity rates of the qualitative test in detecting Rec (11–58%) [7, 18–20]. In contrast, the quantitative NMP22BC test is measured on a continuous scale and then transformed into a dichotomous variable by choosing a cut-off threshold (estimated at 10 ng/mL).…”