Prospective Analysis of Sinus Symptoms and Correlation with Paranasal Computed Tomography Scan

Kenny, Thomas J.; Duncavage, James A.; Bracikowski, J; Yıldırım, Aslı; Murray, John; Tanner, S. Bobo

doi:10.1067/mhn.2001.116779

Cited by 118 publications

(115 citation statements)

References 11 publications

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“…91,108 Interestingly, sleep disturbance, fatigue, nasal blockage, and nasal discharge were more reliable predictors of a rhinosinusitis diagnosis (confirmed by computed tomography scan) than were headache or facial pain or pressure. 109 Most patients with symptoms of acute rhinosinusitis are treated with antibiotics; however, the viral nature of most rhinosinusitis infections suggest that antibiotics may be overused. 110,111 Patients with chronic rhinosinusitis, and chronic rhinosinusitis with nasal polyposis, commonly present with nasal obstruction, nasal discharge, facial pressure, pain, and hyposmia of prolonged duration.…”

Section: Acute Rhinosinusitis and Nasal Polyposis: Association With Amentioning

confidence: 99%

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Storms¹

2008

Primary Care Respiratory Journal

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Allergic rhinitis (AR) is an extremely common health problem affecting 20 to 40 million Americans and between 10-25% of the world's population. Patients with AR suffer from both nasal symptoms (congestion, rhinorrhea, itching, and sneezing) and ocular symptoms (itching, redness, and tearing). The negative impact on sleep quality and quantity, and consequently on various aspects of the patient's life, is an under-recognised and under-treated component of AR morbidity. Nasal congestion, which is one of the most bothersome and prevalent symptoms of AR, is thought to be the leading symptom responsible for rhinitis-related sleep problems.In addition to reducing clinical symptoms, pharmacologic therapies for AR that specifically reduce inflammatory cells and mediators -and therefore nasal congestion and other symptoms -should also improve sleep quality and overall quality of life (QOL). Intranasal corticosteroids (INS) are the current mainstay of therapy for AR. Results of a number of clinical trials demonstrate that INS effectively reduce nasal congestion and ocular symptoms, improve sleep quality, and decrease daytime somnolence. Intranasal corticosteroids have also proved to be effective in reducing symptoms of acute rhinosinusitis and nasal polyposis, both of which also negatively impact on sleep quality. Intranasal corticosteroids are considered safe due to their low systemic bioavailability.

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Section: Acute Rhinosinusitis and Nasal Polyposis: Association With Amentioning

confidence: 99%

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Storms¹

2008

Primary Care Respiratory Journal

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“…The American Academy of Otolaryngology has recommended the Lund and Mackay system for CT staging of CRS [18]. The choice of CRS therapy depends upon symptom intensity and includes topical steroids, antibiotics and/or surgery [19,20].…”

Section: Introductionmentioning

confidence: 99%

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Dżaman

Zagor

Molińska-Glura

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Chronic rhinosinusitis (CRS) affects 14% of the world population. The high motility group box 1 (HMGB1) protein triggers inflammation, cell proliferation and cell survival through its receptor for advanced glycation end products (RAGE) upon release from stressed or necrotic cells. The aim of the study was to analyze the expression and function of HMGB1 and RAGE in CRS, providing more information about HMGB1 signaling pathway in CRS, to determine its potential clinical significance. Material and methods. Thirty-seven patients with CRS and 26 normal controls (NC) were enrolled in this study. Classification of disease severity using the SNOT-20 questionnaire, nasal endoscopy, CT scan, assessment of allergy status, microbiological and cytological analysis was performed in patients. Fresh sinus mucosa samples were obtained and analyzed by immunohistochemistry for HMGB1 and RAGE expression in epithelial cells. ELISA assay was performed to evaluate the concentration of HMGB1 in the patients' sera. Results. No differences were found in HMGB1 immunoexpression between CRS patients and NC, however there was a highly significant difference in RAGE immunoexpression between both groups. There was a correlation between RAGE expression and number of tissue-infiltrating lymphocytes. Further, RAGE expression positively correlated with disease severity and a positive history for allergies. Conclusions. Interaction of HMGB1 and RAGE might be relevant to CRS pathomechanisms leading to sinus mucosa hyperproliferation. CRS pathogenesis might be especially related to the RAGE overexpression correlated with disease severity and allergy.

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“…24,25 Although publications on the correlation of symptoms of CRS to CT findings exist in the literature, similar works using plain radiographs of the PNS are not as numerous. [26][27][28] Da Lilly-Tariah et al in a similar study concluded that plain radiographs were useful in the diagnosis of chronic diseases of the paranasal sinuses while Kolo et al working in the northern part of Nigeria found the usefulness of plain sinus radiographs in the diagnosis of CRS questionable. 25,29 He also reported a weak insignificant correlation between symptom severity scores and findings on plain radiographs of the paranasal sinuses.…”

Section: Discussionmentioning

confidence: 99%

Chronic rhinosinusitis: the correlation between symptom severity score and findings on plain radiographs of the paranasal sinuses

Idugboe

Otoghile

Musa³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Chronic rhinosinusitis (CRS) is a common clinical problem with often refractory symptoms. Though computed tomography scan of the paranasal sinuses (PNS) is the radiological gold standard for confirming the diagnosis of CRS, it is not readily available and affordable in developing countries. Hence plain radiographs are heavily relied upon to confirm the diagnosis of CRS. The reliability and adequacy of plain sinus radiographs in combination with disease specific questionnaires in the management of CRS is still debatable. The objectives of the study were to determine the correlation between symptom severity score and findings on plain radiograph of the PNS in adult patients with CRS.Methods: This was an eight month prospective cross sectional study (April-November, 2014) of Fifty- two consecutive newly diagnosed adult patients with CRS. Results: Age of patients ranged from 19–91 years. Male to female ratio was 1:1.26. There was significant positive correlation between high and moderate symptom severity score (severe and moderate disease) with findings on plain radiograph of the PNS (p=0.032 and 0.048 respectively).Conclusions: The overall symptom severity score of CRS correlates with findings on the plain radiographs of patients with CRS especially in severe and moderate disease.

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Prospective Analysis of Sinus Symptoms and Correlation with Paranasal Computed Tomography Scan

Cited by 118 publications

References 11 publications

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

Allergic rhinitis-induced nasal congestion: its impact on sleep quality

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Chronic rhinosinusitis: the correlation between symptom severity score and findings on plain radiographs of the paranasal sinuses

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