Prospective analysis on brain magnetic resonance imaging in children

Biebl, Ariane; Frechinger, Bettina; Fellner, Christine M.; Ehrenmüller, Margit; Povysil, B.; Fellner, Franz A.; Schimrigk, К.; Furthner, Dieter

doi:10.1016/j.ejpn.2015.01.008

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…In this study, 155/436 (35.5%) had normal findings, 163/436 (37.4%) had incidental findings, and 118/436 (27.1%) had pathologic findings on brain MRI. 15 In the present study, 18.3% overall had definite pathology. It is not surprising that our percentage of pathology is lower, given that many of the children studied in the Biebl et al study had significant medical concerns, whereas a larger percentage of children in the present study were not ill.…”

Section: Discussionsupporting

confidence: 47%

The Implications of Brain MRI in Autism Spectrum Disorder

et al. 2016

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Our objective was to describe the types of providers who refer children with autism spectrum disorder (ASD) for brain magnetic resonance imaging (MRI), the referral reason, and MRI results. The most common referral reasons were autism spectrum disorder with seizures (33.7%), autism spectrum disorder alone (26.3%), and autism spectrum disorder with abnormal neurologic examination or preexisting finding (24%). Neurology (62.5%), general pediatric (22.3%), and developmental/behavioral practitioners (8.9%) referred the most patients. The prevalence of definite pathology was highest in children referred for autism spectrum disorder with abnormal neurologic examination/preexisting finding (26.2%, 95% CI: 16.8%-36%), headaches (25.7%, 95% CI: 11.2%-40.2%), or seizures (22%, 95% CI: 14.6%-29.5%), and was lowest in children referred for autism spectrum disorder alone (6.5%, 95% CI: 1.5%-11.6%). We concluded that there is a low prevalence of definite pathology in children with autism spectrum disorder undergoing brain MRI. In children with abnormal neurologic examination or preexisting finding, seizures, or headaches, one may consider performing brain MRI given the higher prevalence of pathology.

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Section: Discussionsupporting

confidence: 47%

The Implications of Brain MRI in Autism Spectrum Disorder

et al. 2016

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“…Finally, there is some evidence that male fetuses may be more vulnerable to perturbations of growth than female fetuses [Ricart et al, ]. Additionally, younger age was significantly associated with IF, which has not been previously reported [Biebl et al, ; Gur et al, ; Kim et al, ]. This finding may reflect a developmental process by which asymptomatic incidental brain findings resolve with age, and presumably, incidental brain findings that may become troublesome are those that do not resolve, which is consistent with our observation of subjects with IF requiring clinical follow‐up being older than those with IF that did not require follow‐up.…”

Section: Discussionmentioning

confidence: 88%

Incidental brain MRI findings in an autism twin study

et al. 2016

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Brain magnetic resonance imaging (MRI) studies suggest the prevalence of asymptomatic "incidental" findings (IF) in autism spectrum disorder (ASD) is similar to that of neurotypically developing (NT) controls. However, given the causes of IF may include both genetic and environmental factors, a twin study would facilitate comparing brain IF between ASD and NT subjects. MRI scans were examined to assess the prevalence of brain IF in twin "case pairs" (at least one twin with diagnosis of ASD) and twin "control pairs" (NT). Fifty case pairs and thirty-two control pairs were analyzed. IF were found in 68% of subjects with ASD, 71% of unaffected ASD siblings, and in 58% of control subjects (P = 0.4). IF requiring clinical follow-up occurred more frequently in subjects with ASD compared to NT controls (17% vs. 5%, respectively; P = 0.02). The concordance rate of IF in twins was 83%. A mixed effects model found younger age, male sex, and "family environment" to be significantly associated with IF. There was no difference in the prevalence rate of IF between ASD subjects and NT controls. More IF required clinical follow-up in ASD subjects compared to NT controls. The prevalence rate of IF observed in this twin study was higher than rates previously reported in singleton studies. Our results suggest the shared environment of twins - perhaps in utero - increases the risk of brain IF. Brain MRI in the initial work-up of ASD may be indicated in twins, especially in males. Autism Res 2017, 10: 113-120. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.

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“…In our cohort, the prevalence of incidental findings was 22%. Studies vary but prevalence of up to one-third has been reported [ 10 , 12 , 13 ]. Incidental finding rates between children with ASD and neurotypically developing children appear to be similar, 5.5–68% [ 14 – 16 ].…”

Section: Discussionmentioning

confidence: 99%

Yield of brain MRI in children with autism spectrum disorder

et al. 2023

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Autism spectrum disorder (ASD) is a common neurodevelopmental condition. The American Academy of Paediatrics and American Academy of Neurology do not recommend routine brain magnetic resonance imaging (MRI) in the assessment of ASD. The need for a brain MRI should be decided on atypical features in the clinical history and examination. However, many physicians continue to use brain MRI routinely in the assessment process. We performed a retrospective review of indications for requesting brain MRI in our institution over a 5-year period. The aim was to identify the yield of MRI in children with ASD and calculate the prevalence of significant neuroimaging abnormalities in children with ASD and identify clinical indications for neuroimaging. One hundred eighty-one participants were analysed. An abnormal brain MRI was identified in 7.2% (13/181). Abnormal brain MRI was more likely with an abnormal neurological examination (OR 33.1, p = 0.001) or genetic/metabolic abnormality (OR 20, p = 0.02). In contrast, abnormal MRI was not shown to be more likely in children with a variety of other indications such as behavioural issues and developmental delay. Conclusion: Thus, our findings support that MRI should not be a routine investigation in ASD, without additional findings. The decision to arrange brain MRI should be made on a case-by-case basis following careful evaluation of potential risks and benefits. The impact of any findings on the management course of the child should be considered prior to arranging imaging. What is Known:• Incidental brain MRI findings are common in children with and without ASD.• Many children with ASD undergo brain MRI in the absence of neurological comorbidities. What is New:• Brain MRI abnormalities in ASD are more likely with an abnormal neurological examination and genetic or metabolic conditions.• Prevalence of significant brain MRI abnormalities in ASD alone is low.

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Prospective analysis on brain magnetic resonance imaging in children

Cited by 7 publications

References 14 publications

The Implications of Brain MRI in Autism Spectrum Disorder

The Implications of Brain MRI in Autism Spectrum Disorder

Incidental brain MRI findings in an autism twin study

Yield of brain MRI in children with autism spectrum disorder

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