Prospective association of depression and phobic anxiety with changes in telomere lengths over 11 years

Chang, Shun‐Chiao; Crous‐Bou, Marta; Prescott, Jennifer; Rosner, Bernard; Simon, Naomi M.; Wang, Wei; Vivo, Immaculata De; Okereke, Olivia I.

doi:10.1002/da.22732

Cited by 12 publications

(7 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A recent meta-analysis of longitudinal and cross-sectional studies examining the association of depression with TL, found no association for the pooled longitudinal result (R = −0.001; 95% CI, −0.08; 0.08; p = 0.98; Schutte & Malouff, 2015) a significant association was indicated for the pooled cross-sectional studies (Schutte & Malouff, 2015). In the last year, our group also examined relations of depression to prospective change in RTL in a subset of n = 1,250 NHS participants; Chang et al (2018) similarly observed no significant association between baseline depression and 11-year telomere attrition, although point estimates and statistical trends were consistently in the direction of worse telomere attrition among those with versus without depression. Overall, longitudinal evidence remains relatively sparse.…”

Section: Discussionmentioning

confidence: 89%

“…This analysis included a limited subset (n = 1,039) of women who were part of a second NHS blood collection in 2000/2001, had available RTL data at both blood collections and were alive as of the 2000 questionnaire cycle, as described elsewhere (Chang et al, 2018). Table 1 displays the baseline characteristics of the analytic sample (n = 8,801) by RTL z-score quartile.…”

Section: Secondary Analysesmentioning

confidence: 99%

See 1 more Smart Citation

The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background: Telomeres cap and protect DNA but shorten with each somatic cell division. Aging and environmental and lifestyle factors contribute to the speed of telomere attrition. Current evidence suggests a link between relative telomere length (RTL) and depression but the directionality of the relationship remains unclear. We prospectively examined associations between RTL and subsequent depressive symptom trajectories.Methods: Among 8,801 women of the Nurses' Health Study, depressive symptoms were measured every 4 years from 1992 to 2012; group-based trajectories of symptoms were identified using latent class growth-curve analysis. Multinomial logistic models were used to relate midlife RTLs to the probabilities of assignment to subsequent depressive symptom trajectory groups.Results: We identified four depressive symptom trajectory groups: minimal depressive symptoms (62%), worsening depressive symptoms (14%), improving depressive symptoms (19%), and persistent-severe depressive symptoms (5%).Longer midlife RTLs were related to significantly lower odds of being in the worsening symptoms trajectory versus minimal trajectory but not to other trajectories. In comparison with being in the minimal symptoms group, the multivariable-adjusted odds ratio of being in the worsening depressive symptoms group was 0.78 (95% confidence interval, 0.62-0.97; p = 0.02), for every standard deviation increase in baseline RTL. Conclusions:In this large prospective study of generally healthy women, longer telomeres at midlife were associated with significantly lower risk of a subsequent trajectory of worsening mood symptoms over 20 years. The results raise the possibility of telomere shortening as a novel contributing factor to late-life depression. K E Y W O R D S depression, depressive symptoms, late-life, telomeres, trajectories Depress Anxiety. 2019;36:565-575. wileyonlinelibrary.com/journal/da

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Secondary Analysesmentioning

confidence: 99%

The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, these authors found no difference in telomere attrition rate among the groups when they evaluated TL and diagnosis status over time (from baseline to 6-year follow-up). Prospective studies testing the hypothesis that anxiety symptoms and diagnoses precede telomere shortening showed inconsistent findings 20 – 23 , 55 . Therefore, these inconsistent results and the lack of longitudinal studies reveal that there is a gap to be filled concerning TL and anxiety 56 .…”

Section: Discussionmentioning

confidence: 99%

Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

Baumont

Hoffmann

Bortoluzzi

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Evidence on the relationship between genetics and mental health are flourishing. However, few studies are evaluating early biomarkers that might link genes, environment, and psychopathology. We aimed to study telomere length (TL) and epigenetic age acceleration (AA) in a cohort of adolescents with and without anxiety disorders (N = 234). We evaluated a representative subsample of participants at baseline and after 5 years (n = 76) and categorized them according to their anxiety disorder diagnosis at both time points: (1) control group (no anxiety disorder, n = 18), (2) variable group (anxiety disorder in one evaluation, n = 38), and (3) persistent group (anxiety disorder at both time points, n = 20). We assessed relative mean TL by real-time quantitative PCR and DNA methylation by Infinium HumanMethylation450 BeadChip. We calculated AA using the Horvath age estimation algorithm and analyzed differences among groups using generalized linear mixed models. The persistent group of anxiety disorder did not change TL over time (p = 0.495). The variable group had higher baseline TL (p = 0.003) but no accelerated TL erosion in comparison to the non-anxiety control group (p = 0.053). Furthermore, there were no differences in AA among groups over time. Our findings suggest that adolescents with chronic anxiety did not change telomere length over time, which could be related to a delay in neuronal development in this period of life.

show abstract

“…LTL may be a marker for the construct of "biological age" since inter-individual variation can arise from genetic, lifestyle, and disease factors among people of the same chronological age (Cai, Yan, & Ratka, 2013;Eitan, Hutchison, & Mattson, 2014;Grodstein et al, 2008;Herrmann, Pusceddu, Marz, & Herrmann, 2018;Honig et al, 2006Honig et al, , 2012. Studies have indicated that LTL may reflect cumulative damage from cellular stress and heightened inflammatory responses, which allow it to serve as an indicator of biological or cellular aging (Chang et al, 2018). Persons with longer average LTL may be biologically "younger" than those with shorter average LTL.…”

Section: Introductionmentioning

confidence: 99%

“…Extant literature further demonstrates how shorter LTL may be associated with mortality and several age-related diseases like cancer, cardiovascular disease, type II diabetes, and neurodegenerative disorders such as Parkinson's Disease, Huntington's Disease, and Alzheimer's Disease (AD) (Cai et al, 2013;Degerman et al, 2014;Forero et al, 2016;Herrmann et al, 2018;Honig et al, 2012;Insel, Merkle, Hsiao, & Vidrine, 2012;Ma et al, 2013;Scarabino, Broggio, Gambina, & Corbo, 2017;Wikgren et al, 2014). Some studies have also found relationships between LTL with neuropsychiatric disorders such as depression, anxietyrelated disorders, schizophrenia, and other psychotic disorders, as well as bipolar disorder (Richard, Reitz, Honig, Schupf, & Tamg, 2013;Chang et al, 2018;Czepielewski et al, 2018;Nieratschker et al, 2013, Powell, Dima, Frangou, & Breen, 2018Vasconcelos-Moreno et al, 2017;Wang et al, 2017;Colpo, Leffa, Quevedo, & Carvalho, 2015;Lindqvist et al, 2015). Such aging-, metabolic-, psychiatric-, and inflammation-related conditions have all been associated with cognitive outcomes (Cohen-Manheim et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants

Ashrafi

Cosentino

Kang

et al. 2020

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Objective: Leukocyte telomere length (LTL) is a widely hypothesized biomarker of biological aging. Persons with shorter LTL may have a greater likelihood of developing dementia. We investigate whether LTL is associated with cognitive function, differently for individuals without cognitive impairment versus individuals with dementia or incipient dementia. Method: Enrolled subjects belong to the Long Life Family Study (LLFS), a multi-generational cohort study, where enrollment was predicated upon exceptional family longevity. Included subjects had valid cognitive and telomere data at baseline. Exclusion criteria were age ≤ 60 years, outlying LTL, and missing sociodemographic/clinical information. Analyses were performed using linear regression with generalized estimating equations, adjusting for sex, age, education, country, generation, and lymphocyte percentage. Results: Older age and male gender were associated with shorter LTL, and LTL was significantly longer in family members than spouse controls (p < 0.005). LTL was not associated with working or episodic memory, semantic processing, and information processing speed for 1613 cognitively unimpaired individuals as well as 597 individuals with dementia or incipient dementia (p < 0.005), who scored significantly lower on all cognitive domains (p < 0.005). Conclusions: Within this unique LLFS cohort, a group of families assembled on the basis of exceptional survival, LTL is unrelated to cognitive ability for individuals with and without cognitive impairment. LTL does not change in the context of degenerative disease for these individuals who are biologically younger than the general population.

show abstract

Prospective association of depression and phobic anxiety with changes in telomere lengths over 11 years

Cited by 12 publications

References 57 publications

The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women

The relation of telomere length at midlife to subsequent 20‐year depression trajectories among women

Telomere length and epigenetic age acceleration in adolescents with anxiety disorders

Leukocyte Telomere Length Is Unrelated to Cognitive Performance Among Non-Demented and Demented Persons: An Examination of Long Life Family Study Participants

Contact Info

Product

Resources

About