2003
DOI: 10.1148/radiol.2271011989
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Prospective Blinded Evaluation of Gd-DOTA– versus Gd-BOPTA–enhanced Peripheral MR Angiography, as Compared with Digital Subtraction Angiography

Abstract: At MR angiography of the distal run-off vessels, Gd-BOPTA yielded higher specificity and a significantly smaller number of nonassessable segments than Gd-DOTA. The diagnostic accuracy of the two gadolinium chelates at peripheral MR angiography was comparable in the renal to popliteal arteries.

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Cited by 68 publications
(44 citation statements)
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“…Of particular relevance for routine practice were the low technical failure rate and improved image quality in the calves. Similar fi ndings have been noted by Knopp et al ( 28 ) and Wyttenbach et al ( 29 ), despite the higher dose used in the latter study. In terms of diagnostic performance, a recent multicenter Phase III study that used a dose of 0.1 mmol/kg of gadobenate dimeglumine revealed diagnostic accuracy values of 85.0%-87.5% in the iliofemoral arteries and 74.5%-77.5% in the calf arteries ( 34 ).…”
Section: Vascular and Interventional Radiology: Contrast Materials Comsupporting
confidence: 92%
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“…Of particular relevance for routine practice were the low technical failure rate and improved image quality in the calves. Similar fi ndings have been noted by Knopp et al ( 28 ) and Wyttenbach et al ( 29 ), despite the higher dose used in the latter study. In terms of diagnostic performance, a recent multicenter Phase III study that used a dose of 0.1 mmol/kg of gadobenate dimeglumine revealed diagnostic accuracy values of 85.0%-87.5% in the iliofemoral arteries and 74.5%-77.5% in the calf arteries ( 34 ).…”
Section: Vascular and Interventional Radiology: Contrast Materials Comsupporting
confidence: 92%
“…Given that the quality of calf vessel visualization in our study was poor in signifi cantly more patients after 0.1 mmol/kg gadopentetate dimeglumine than after 0.1 mmol/kg gadobenate dimeglumine, it is possible that worse overall results might have been obtained in these other studies had below-knee vessels been included in the assessment. More importantly, the comparatively poor quality of vessel visualization with gadopentetate dimeglumine in our study and elsewhere ( 28,29 ), particularly for below-knee arteries, would necessitate a repeat examination with associated increased costs.…”
Section: Vascular and Interventional Radiology: Contrast Materials Commentioning
confidence: 69%
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“…2), which was also observed in other studies [14,17,22]. However, Gd-Dota revealed at least equal image quality with even significantly better arterial visualization-even though with lower SI and CNR values.…”
Section: Discussionsupporting
confidence: 83%