Prospective carriers of 223Ra for targeted alpha particle therapy

Surface protolytic property characterization of hydroxyapatite and titanium dioxide nanoparticles

“…They were chosen due to their radiation stability and size. 17 Firstly, due to nanoparticle size and ability to resorb ions, recoil nuclei remain in the particle and no undesirable irradiation is therefore observed. Secondly, nanoparticles can be targeted to cancer by both passive and active mechanisms, due to the EPR effect or functionalization of the surface.…”

Extraction chromatographic behavior of actinium and REE on DGA, Ln and TRU resins in nitric acid solutions

“…A targeted delivery of radionuclides using various transporters, e.g. peptides [1], monoclonal antibodies [2] or module nanotransporters [3][4][5] to the cancer cells is the most advanced approach. Alpha-emitters 225 Ac (T 1/2 = 10 days) and 213 Bi (T 1/2 = 46 min) are attractive candidates for radiotherapy of tumors [6][7][8].…”

A Monte Carlo study on 223Ra imaging for unsealed radionuclide therapy

“…Radium-223 ( 223 Ra) is an α-emitting radionuclide that is potentially useful in the treatment of prostate cancer with bone metastases because the linear energy transfer of an α particle is higher than that of a beta particle. [1][2][3][4][5][6][7][8] Due to the very short flight range of α particles, it is important to precisely accumulate the nuclides into a target lesion. Therefore, the demand for effective 223 Ra imaging is growing to determine the distribution of the source activity.…”

“…11,12 One great advantage of computer simulations is that each photon detected in the detection process can be classified, as will be shown in Sec. 3. An actual camera cannot discriminate between the detection processes.…”