Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery disease

Caribé, Pérola Michelle Vasconcelos; Villar, Cristina Cunha; Romito, G. A; Takada, Julio Yoshio; Pacanaro, Ana Paula; César, Luiz Antonio Machado; Mansur, Antônio de Pádua

doi:10.1177/2040622320919621

Cited by 4 publications

(10 citation statements)

References 54 publications

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“…It remains mainly unknown. 14 However, in a large prospective study of apparently healthy individuals, high‐serum MBL‐2 levels in men were associated with a higher risk of developing coronary heart disease in future. This association was independent of cardiovascular risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with and without coronary artery disease (CAD) who received an agent for atherosclerosis and periodontitis (PD) had lower serum MBL-2 levels. 13,14 Elevated serum MBL-2 levels are associated with the development of myocardial infarction and an unfavorable prognosis in coronary artery disease (CAD). 14 Tenascin-C (TNC) also plays an essential role in the development and progression of atherosclerotic plaques through cell migration and proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 Elevated serum MBL-2 levels are associated with the development of myocardial infarction and an unfavorable prognosis in coronary artery disease (CAD). 14 Tenascin-C (TNC) also plays an essential role in the development and progression of atherosclerotic plaques through cell migration and proliferation. 15 In contrast, TNC promotes fibrosis and exerts repair effects on an experimental aneurysm through macrophage-induced smooth muscle cell migration and proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…Patients with and without coronary artery disease (CAD) who received an agent for atherosclerosis and periodontitis (PD) had lower serum MBL‐2 levels. 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

“…A high prevalence of coronary artery disease (CAD) is associated with high MBL‐2 levels. Patients with and without coronary artery disease (CAD) who received an agent for atherosclerosis and periodontitis (PD) had lower serum MBL‐2 levels 13,14 …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

Mehri

Aslanabadi

Nourazarian

et al. 2021

Clinical Laboratory Analysis

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show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Patients with and without coronary artery disease (CAD) who received an agent for atherosclerosis and periodontitis (PD) had lower serum MBL‐2 levels. 13 , 14 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

Mehri

Aslanabadi

Nourazarian

et al. 2021

Clinical Laboratory Analysis

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The relationship between SIRT1 and inflammation: a systematic review and meta-analysis

Sun,

Li,

Wei

et al. 2024

Front. Immunol.

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Recent studies underscore the anti-inflammatory role of SIRT1; however, its levels during inflammatory states remain ambiguous. We synthesized relevant studies up to 20 March 2024 to evaluate the relationship between SIRT1 and inflammation, using data from three major databases. Employing a random-effects model, we analyzed both cross-sectional and longitudinal studies, calculating weighted mean differences (WMDs) for pooled effect sizes. Subgroup and sensitivity analyses, along with a risk of bias assessment, were also conducted. We reviewed 13 publications, encompassing 21 datasets and 2,028 participants. The meta-analysis indicated higher SIRT1 levels in inflammatory groups compared to control groups pre-adjustment (WMD, 3.18 ng/ml; 95% CI 2.30, 4.06 ng/ml; P<0.001; I²= 99.7%) and post-adjustment (WMD, 0.88 ng/ml; 95% CI 0.14, 1.62 ng/ml; P<0.001; I²= 99.5%). Notably, middle-aged patients with inflammation exhibited lower SIRT1 levels (WMD, −0.85 ng/ml; 95% CI −1.47, −0.22 ng/ml; P= 0.008; I²= 95.4%), while groups characterized by East Asian descent, plasma studies, autoimmune conditions, and musculoskeletal disorders showed higher levels. The findings suggest that inflammation generally upregulates SIRT1, potentially elucidating its role in immunobiological processes. However, the significant heterogeneity observed, partly due to the cross-sectional nature of some data, limits insights into the duration of disease progression, which remains highly variable.

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Mannose-Binding Lectin Reduces Oxidized Low-Density Lipoprotein Induced Vascular Endothelial Cells Injury by Inhibiting LOX1-ox-LDL Binding and Modulating Autophagy

et al. 2023

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Objective: To investigate the role of mannose-binding lectin (MBL) in modulating autophagy and protecting endothelial cells (ECs) from oxidized low-density lipoprotein (ox-LDL)-induced injury. Methods: Serum MBL concentration and carotid intima-media thickness (cIMT) were measured in 94 obese and 105 healthy children. ECs were transfected with MBL over-expression plasmid, LOX1 was knocked-down to explore the protective role of MBL in ox-LDL induced ECs injury. Dendritic cells (DCs) were co-cultured with ECs, and inflammatory factors, DC maturation, and autophagy was assessed. WT and ApoE-/- mice were fed with a high fat diet (HFD) with or without MBL-adenovirus injection for 16 weeks and aortic vascular endothelial tissue was isolated, then atherosclerotic plaque, cell injury and autophagy were analyzed. Results: Serum MBL concentration in obese children was lower than healthy controls and was negatively correlated with cIMT. The uptake of ox-LDL was decreased in LOX1 knock-down ECs. MBL over-expression in vitro inhibited LOX1-ox-LDL binding. Both LOX1 knock-down and MBL over-expression can ameliorate EC autophagy and cell injury. MBL over-expression in vivo alleviated atherosclerotic plaque formation, influenced DC maturation and down-regulated IL-6, IL-12, and TNF-a levels. Conclusion: MBL exerts a protective role in ox-LDL-induced EC injury by modulating DC maturation and EC autophagy via inhibiting LOX1-ox-LDL binding.

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Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery disease

Cited by 4 publications

References 54 publications

Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

The relationship between SIRT1 and inflammation: a systematic review and meta-analysis

Mannose-Binding Lectin Reduces Oxidized Low-Density Lipoprotein Induced Vascular Endothelial Cells Injury by Inhibiting LOX1-ox-LDL Binding and Modulating Autophagy

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