Prospective change in daily walking over 2 years in older adults with or at risk of knee osteoarthritis: the MOST study

White, Daniel K.; Tudor‐Locke, Catrine; Niu, Jingbo; Felson, David T.; Gross, K.D.; Nevitt, Michael C.; Lewis, Cora E.; Torner, James C.; Neogi, Tuhina

doi:10.1016/j.joca.2015.08.004

Cited by 26 publications

(22 citation statements)

References 50 publications

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“…White et al 44 found that people with underlying structural worsening trended towards less walking and were more likely to fall below the 6000 step/day threshold, suggesting functional limitation. People who are predisposed to OA or have confirmed OA should not be discouraged from walking and can benefit from AA 45 .…”

Section: Discussionmentioning

confidence: 99%

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Zhu

Aitken

Cicuttini

et al. 2019

Osteoarthritis and Cartilage

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s u m m a r yObjective: To investigate the longitudinal association between objectively measured ambulatory activity (AA) and knee MRI-detected osteophytes (OPs), and to test whether this relationship was modified by common risk factors for OA including sex, obesity, disease severity and knee injury history. Methods: 408 community-dwelling adults aged 51e81 years were assessed at baseline and 2.7 years. T1weighted fat-suppressed MRI was used to evaluate knee OPs at both time points. AA was assessed at baseline by pedometers and categorized as: less active ( 7499 steps per day), moderately active (7500 e9999 steps per day) and highly active (!10,000 steps per day). Results: Statistically significant interactions were detected between knee OA risk factors and AA on increases in MRI-detected OPs (all P < 0.05). In stratified analyses, being moderately active, compared to being less active, was protective against an increase in MRI-detected OPs (score change of !1) in females (relative risk (RR) ¼ 0.42, 95%CI, 0.25e0.70, P < 0.01), those who were obese (RR ¼ 0.50, 95%CI, 0.30 e0.83, P < 0.01), those with radiographic OA (ROA) (RR ¼ 0.68, 95%CI, 0.47e0.97, P ¼ 0.02) and those with a history of knee injury (RR ¼ 0.27, 95%CI, 0.08e0.88, P ¼ 0.02) in almost every knee compartment, after adjustment for confounders. No statistically significant associations were found in males, non-obese, non-ROA or non-injury groups. Conclusions: Being moderately active is protective against an increase in MRI-detected OPs in females, those with ROA, those who are obese and those with a history of knee injury. These findings suggest that being moderately active is beneficial for individuals who are at higher risk of knee OA.

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Section: Discussionmentioning

confidence: 99%

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Zhu

Aitken

Cicuttini

et al. 2019

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

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“…Poor sleep quality included “fairly poor” or “very bad” while good sleep included “fairly good” and “very good”. Overall comorbidity was assessed using the modified Charlson comorbidity index . The modified WOMAC pain subscale which ranged from 0 to 20 was used in reporting knee pain in “the past 30 days” .…”

Section: Methodsmentioning

confidence: 99%

Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis: The MOST Study

et al. 2020

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Aim:The aim of the study was to identify sociodemographic, disease-related, physical and mental health-related determinants of fatigue at 2-year follow-up in individuals with symptomatic knee osteoarthritis (OA). Methods:A longitudinal analysis of participants with symptomatic knee OA from the Multicenter Osteoarthritis Study (MOST) was conducted to identify predictors of fatigue at 2-year follow-up. Participants self-reported fatigue at baseline for the first time in the MOST cohort and at follow-up using a 0-10 visual analog scale. At baseline, questionnaires on sociodemographics, disease-related symptoms, physical and mental health factors were completed. Data were analyzed using linear regressions with a backwards elimination approach. Results: Of the 2330 individuals in the MOST cohort at baseline, 576 had symptomatic knee OA and of these, 449 with complete fatigue values at baseline and follow-up were included in this analysis. Minimally important fatigue change (ie, worsening [≥1.13], no change [<0.82 or <1.13] and improvement [≥−0.82]) from baseline to follow-up were unequal within the population (34.5%, 26.9%, 38.5%; χ 2 [2, N = 449] = 9.32, P = .009). The multiple linear regression showed that baseline fatigue (unstandardized coefficient [Β] = 0.435; 95% confidence interval [CI] 0.348-0.523, P < .001), slow gait speed (Β = −1.124; 95% CI −1.962 to −0.285, P = .009), depressive symptoms (Β = 0.049; 95% CI 0.024-0.075, P < .001) and higher numbers of comorbidities (Β = 0.242; 95% CI 0.045-0.439, P = .016) were significant predictors of greater fatigue at follow-up. Conclusion: Fatigue is strongly associated with physical-and mental-related health factors. Individualized treatments that include combined psychological and physical function rehabilitation might be modalities for fatigue management. K E Y W O R D S fatigue, knee osteoarthritis, longitudinal, risk factors

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“…Depression and pain commonly occur together 93 due to a mutually reinforcing relationship. People with OA and concomitant depression symptoms are less active (decline in steps/day) 94 , respond less to systematic depression treatment and have worse pain and depression outcomes 95 .…”

Section: Depression and Mental Healthmentioning

confidence: 99%

Efficacy and safety of Cortex Eucommiae (Eucommia ulmoides Oliver) extract in subjects with mild osteoarthritis

et al. 2019

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Background Osteoarthritis (OA) is a major degenerative disease that affects the elderly. The global prevalence of OA is increasing annually. However, current treatments are unable to halt the progress of OA. At present, pharmacological treatments such as non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 (COX-2) inhibitors control the pain; however, there may be side effects to these medications. We hypothesized that Cortex Eucommiae (CE; Eucommia ulmoides Oliver) extract, which is used as a dietary supplement, may slow down or prevent OA. Methods This is a protocol for a 12-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of CE extract in subjects with mild OA. One-hundred subjects with mild OA will be recruited and randomly divided in a 1:1 ratio into 2 groups. One group will receive CE extract for 12 weeks and the other group will receive placebo for 12 weeks. Outcomes will be evaluated by using the visual analog scale (VAS), Korean-Western Ontario and McMaster Universities index (K-WOMAC), Korean-Short Form health survey-36 score (KSF-36), and laboratory test results. Discussion This clinical trial is expected to provide evidence of the efficacy and safety of CE extract as a treatment for mild OA. Trial registration Clinical Trials.gov NCT03744611, registered on November 12, 2018, at https://clinicaltrials.gov/ct2/show/NCT03744611

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Prospective change in daily walking over 2 years in older adults with or at risk of knee osteoarthritis: the MOST study

Cited by 26 publications

References 50 publications

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Ambulatory activity interacts with common risk factors for osteoarthritis to modify increases in MRI-detected osteophytes

Determinants of generalized fatigue in individuals with symptomatic knee osteoarthritis: The MOST Study

Efficacy and safety of Cortex Eucommiae (Eucommia ulmoides Oliver) extract in subjects with mild osteoarthritis

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