Prospective comparison of 3D FIESTA versus fat-suppressed 3D SPGR MRI in evaluating knee cartilage lesions

Li, X.; Yu, Cheng; Wu, Hsiang Ling; Daniel, Kurt R.; Hu, Di; Xia, Liming; Pan, Chengjun; Xu, Aiming; Hu, Jerry C.; Wang, L.; Peng, Wenjie; Li, F.

doi:10.1016/j.crad.2009.07.008

Cited by 16 publications

(19 citation statements)

References 19 publications

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“…The abstracts of all 1879 studies were reviewed and 52 articles met the pre-determined inclusion and exclusion criteria. Fourteen level I, 7, 14, 16, 17, 27, 37, 40–43, 50, 72, 84, 85 13 level II 4, 10, 26, 28, 38, 39, 47, 55, 59, 74, 78, 80, 90 and 26 level III–V 5, 8, 12, 23, 29, 31–33, 35, 36, 44, 48, 49, 54, 60, 63–65, 69, 75, 81–83, 86, 93 studies were identified. For level I and II studies, Table 2 describes the breakdown of the number of articles that reported results regarding diagnostic performance of MRI compared to arthroscopy for grading of chondral involvement, reliability of grading between evaluators, MRI sequence performance, and involved articular cartilage surface or knee compartment.…”

Section: Resultsmentioning

confidence: 99%

“…16 The lateral tibial plateau appeared to have the lowest sensitivity of all surfaces and interestingly, Li et al reported the lowest interobserver agreement for grades in the lateral tibial compartment as well. 50 Collectively, the specificity and accuracy of identifying articular cartilage degeneration was relatively high for all surfaces and compartments. The large differences in reported diagnostic performance of MRI for identifying articular cartilage degeneration may be attributable to the wide variety of different image slice sizes, surface coil sizes and shapes, types of scanners, sequencing techniques, and grading systems that were utilized for each study.…”

Section: Discussionmentioning

confidence: 97%

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The Clinical Utility and Diagnostic Performance of Magnetic Resonance Imaging for Identification of Early and Advanced Knee Osteoarthritis

et al. 2011

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Background Current diagnostic strategies for detection of structural articular cartilage abnormalities, the earliest structural signs of osteoarthritis, often do not capture the condition until it is too far advanced for the most potential benefit of non-invasive interventions. Purpose Systematically review the literature relative to the following questions: (1) Is MRI a valid, sensitive, specific, accurate and reliable instrument to identify knee articular cartilage abnormalities compared to arthroscopy? (2) Is MRI a sensitive tool that can be utilized to identify early cartilage degeneration? Study Design Systematic Review Methods A systematic search was performed in November 2010 using PubMed MEDLINE (from 1966), CINAHL (from 1982), SPORTDiscus (from 1985), and SCOPUS (from 1996) databases. Results Fourteen level I and 13 level II studies were identified that met inclusion criteria and provided information related to diagnostic performance of MRI compared to arthroscopic evaluation. The diagnostic performance of MRI demonstrated a large range of sensitivities, specificities, and accuracies. The sensitivity for identifying articular cartilage abnormalities in the knee joint was reported between 26–96%. Specificity and accuracy was reported between 50–100% and 49–94%, respectively. The sensitivity, specificity, and accuracy for identifying early osteoarthritis were reported between 0–86%, 48–95%, and 5–94%, respectively. As a result of inconsistencies between imaging techniques and methodological shortcomings of many of the studies, a meta-analysis was not performed and it was difficult to fully synthesize the information to state firm conclusions about the diagnostic performance of MRI. Conclusions There is evidence in some MRI protocols that MRI is a relatively valid, sensitive, specific, accurate, and reliable clinical tool for identifying articular cartilage degeneration. Due to heterogeneity of MRI sequences it is not possible to make definitive conclusions regarding its global clinical utility for guiding diagnosis and treatment strategies. Clinical Relevance Traumatic sports injuries to the knee may be significant precursor events to early onset of posttraumatic osteoarthritis. MRI may aid in early identification of structural injuries to articular cartilage as evidenced by articular cartilage degeneration grading.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

The Clinical Utility and Diagnostic Performance of Magnetic Resonance Imaging for Identification of Early and Advanced Knee Osteoarthritis

et al. 2011

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“…Systematic review of all 1,906 abstracts revealed 54 articles that met all exclusion criteria and the first 7 inclusion criteria. In Level I, [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Level II, [42][43][44][45][46][47][48][49][50][51][52][53][54] and Level III-V 55-77 15, 13, and 26 studies were identified, respectively. Of the 54 articles that analyzed the diagnostic performance of MRI relative to arthroscopy for knee articular cartilage lesions, 4 studies (1 Level II study 50 and 3 Level III studies 55,63,66 ) also met the final inclusion criterion, reporting data related to chondral defect size (►Table 2).…”

Section: Resultsmentioning

confidence: 99%

Is Magnetic Resonance Imaging Assessment of the Size of Articular Cartilage Defects Accurate?

et al. 2013

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The purpose of this study was to systematically review the literature relative to the following question: Is preoperative magnetic resonance imaging (MRI) an accurate instrument for the assessment of the size of knee articular cartilage defects compared with arthroscopy? A systematic search was performed in September 2011 using PubMed MEDLINE (from 1966), CINAHL (from 1982), SPORTDiscus (from 1985), SCOPUS (from 1996), and EMBASE (from 1974) databases. Four studies (one study of Level II and three studies of Level III) were identified that met the predetermined inclusion and exclusion criteria. The ability of MRI to preoperatively assess the size of cartilage lesions was highly variable. As a result of inconsistencies between imaging techniques, the methodological variability and shortcomings of the studies, and the limited amount of data available, a meta-analysis was not performed. There is some evidence that MRI is an accurate tool for preoperatively assessing the dimensions of articular cartilage defects. However, because of the heterogeneity of MRI sequences and the paucity of literature related to preoperative sizing, it is not possible to make definitive conclusions regarding the global clinical utility of MRI for guiding the selection of therapeutic strategies.

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“…Our selection of investigated pulse sequences for depiction of GadofluorineM-Cy labeled MASI was based on practical considerations: T1-SE and T2* GE sequences have been previously applied for cell tracking studies [20], [31] and 3D-SPGR and T2-FSE sequences are standard clinical sequences for cartilage imaging [32], [33], [34]. Our data showed, that the T2* GE sequence provides the highest contrast between GadofluorineM-Cy -labeled cell implants and adjacent cartilage defects and is therefore best suited for detection of transplanted stem cells.…”

Section: Discussionmentioning

confidence: 99%

MR Imaging Features of Gadofluorine-Labeled Matrix-Associated Stem Cell Implants in Cartilage Defects

Nejadnik

Henning

et al. 2012

PLoS ONE

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ObjectivesThe purpose of our study was to assess the chondrogenic potential and the MR signal effects of GadofluorineM-Cy labeled matrix associated stem cell implants (MASI) in pig knee specimen.Materials and MethodsHuman mesenchymal stem cells (hMSCs) were labeled with the micelle-based contrast agent GadofluorineM-Cy. Ferucarbotran-labeled hMSCs, non-labeled hMSCs and scaffold only served as controls. Chondrogenic differentiation was induced and gene expression and histologic evaluation were performed. The proportions of spindle-shaped vs. round cells of chondrogenic pellets were compared between experimental groups using the Fisher's exact test. Labeled and unlabeled hMSCs and chondrocytes in scaffolds were implanted into cartilage defects of porcine femoral condyles and underwent MR imaging with T1- and T2-weighted SE and GE sequences. Contrast-to-noise ratios (CNR) between implants and adjacent cartilage were determined and analyzed for significant differences between different experimental groups using the Kruskal-Wallis test. Significance was assigned for p<0.017, considering a Bonferroni correction for multiple comparisons.ResultsCollagen type II gene expression levels were not significantly different between different groups (p>0.017). However, hMSC differentiation into chondrocytes was superior for unlabeled and GadofluorineM-Cy-labeled cells compared with Ferucarbotran-labeled cells, as evidenced by a significantly higher proportion of spindle cells in chondrogenic pellets (p<0.05). GadofluorineM-Cy-labeled hMSCs and chondrocytes showed a positive signal effect on T1-weighted images and a negative signal effect on T2-weighted images while Ferucarbotran-labeled cells provided a negative signal effect on all sequences. CNR data for both GadofluorineM-Cy-labeled and Ferucarbotran-labeled hMSCs were significantly different compared to unlabeled control cells on T1-weighted SE and T2*-weighted MR images (p<0.017).ConclusionhMSCs can be labeled by simple incubation with GadofluorineM-Cy. The labeled cells provide significant MR signal effects and less impaired chondrogenesis compared to Ferucarbotran-labeled hMSCs. Thus, GadoflurineM-Cy might represent an alternative MR cell marker to Ferucarbotran, which is not distributed any more in Europe or North America.

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Prospective comparison of 3D FIESTA versus fat-suppressed 3D SPGR MRI in evaluating knee cartilage lesions

Cited by 16 publications

References 19 publications

The Clinical Utility and Diagnostic Performance of Magnetic Resonance Imaging for Identification of Early and Advanced Knee Osteoarthritis

The Clinical Utility and Diagnostic Performance of Magnetic Resonance Imaging for Identification of Early and Advanced Knee Osteoarthritis

Is Magnetic Resonance Imaging Assessment of the Size of Articular Cartilage Defects Accurate?

MR Imaging Features of Gadofluorine-Labeled Matrix-Associated Stem Cell Implants in Cartilage Defects

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