Prospective comparison of acute motor axonal neuropathy and acute inflammatory demyelinating polyradiculoneuropathy in 140 children with Guillain–Barré syndrome in India

Abstract

AIDP is the most common GBS subtype in children. It is characterized by better recovery at 3 months when compared with AMAN. Muscle Nerve 57: 761-765, 2018.

A Novel Treatment Strategy for Severe Guillain-Barré Syndrome: Zipper Method

“…Although this study does not only include severe Guillain-Barré syndrome patients, the overall mean hospital stay was 16 days, and it was 22 days in acute motor axonal neuropathy patients. 31 Electrophysiologic findings of all patients in our study group were consistent with acute motor axonal neuropathy, and the mean hospital stay of these patients was 18 days ( Table 1). Considering that our patients are more severe, it can be said that the zipper method fastens recovery time.…”

“…30 In a prospective pediatric case series, it was reported that the most common type of Guillain-Barré syndrome is acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy is associated with poor outcome. 31 Mechanical ventilation need was recorded in 24.2% and 13.7% of acute motor axonal neuropathy and acute inflammatory demyelinating polyneuropathy patients, respectively. Although this study does not only include severe Guillain-Barré syndrome patients, the overall mean hospital stay was 16 days, and it was 22 days in acute motor axonal neuropathy patients.…”

“…30 In a recent study about pediatric Guillain-Barré syndrome outcome, it was reported that only 47% of the patients fully recovered and 24.3% of the patients were wheelchair bound at the third month of treatment. 31 Before the zipper method, 4 severe Guillain-Barré syndrome patients were followed in our unit. All of these patients were transferred from the pediatric inpatient service because of disease progression under intravenous immunoglobulin treatment and need for mechanical ventilator.…”

“…30 In a recent study about pediatric Guillain-Barré syndrome outcome, it was reported that only 47% of the patients fully recovered and 24.3% of the patients were wheelchair bound at the third month of treatment. 31…”

<p>Prevalence and outcomes of Guillain-Barr&eacute; syndrome among pediatrics in Saudi Arabia: a 10-year retrospective study</p>

“…In this setting, after 2 months of nadir, the clinical outcomes were better, as 46.9% complained of residual paralysis. It was reported that by the third month, 47.1% of GBS patients are expected to have a complete recovery, while 24.3% will have poor recovery (wheelchair-bound) 40. One longitudinal study stated that the rates of GBS patients with complete recovery or minor limitations was 41% in the first month, 71% in the third, 86% in the sixth, and 92% in the twelfth 41.…”