Prospective Comparison of Opioid vs Nonopioid Pain Regimen After Ureteroscopy

Strategies for optimizing pain management after ureteroscopy

“…This surge in stone disease may be compounded by the effects of climate change, as elevated temperatures increase risk for kidney stones ( 2 ). Ureteroscopy (URS) is a common and effective procedure for stone removal; however postoperative pain, stent-related symptoms, and unplanned healthcare encounters can significantly affect patients’ quality of life ( 3 ). Thus, considerable research has been dedicated to identifying optimal medications or regimens to mitigate patient pain and discomfort through peri-, intra-, and post-operative approaches.…”

“…Similarly, ketorolac was found to be non-inferior to opioids, furthering support for opioid-sparing medication protocols. In 2022, Bevill et al also studied NSAIDs in a broader cohort including older patients, those on anticoagulation, and those experiencing chronic pain ( 3 ). In these patients, selective cyclooxygenase-2 (COX-2) inhibitor yielded comparable pain control without the potential risks associated with non-specific COX inhibitors which carry a risk of gastric and renal toxicity in longer courses.…”