Prospective Controlled Study of Androgen Effects on Red Cell Oxygen Transport and Work Capacity in Chronic Hemodialysis Patients

Hendler, Ernesto D.; Solomon, Lawrence R.

doi:10.1159/000205154

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…Pharma cologic dose of androgens may increase the tissue oxygen requirements [28] but do not significantly improve oxy-gen release from hemoglobin despite the increment in red blood cell mass [29], A relative tissular hypoxia can stimu late the erythropoietin production in some patients un dergoing androgen therapy.…”

Section: Discussionmentioning

confidence: 99%

Evolution of Serum Erythropoietin after Androgen Administration to Hemodialysis Patients: A Prospective Study

Teruel

Marcén²,

Navarro³

et al. 1995

Nephron

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A prospective study of the evolution of serum erythropoietin level after androgen therapy was carried out in a group of 25 male patients on chronic hemodialysis treatment with nonferropenic anemia (serum ferritin > 50 ng/ml). The androgen used was nandrolone decanoate (200 mg/week intramuscularly, for 6 months). There was an increase of serum erythropoietin, that reached statistical significance in the 2nd week of treatment (8.6 ± 6.4 vs. 14.2 ± 9.8 mIU/ ml, p < 0.05), and a stabilization after 1 month (1 month: 17.8 ± 11.2 mIU/ ml, 6 months: 19.6 ± 14.9 mlU/ml). The hemoglobin also experienced a parallel increase to that observed in serum erythropoietin (basal value: 8 ± 0.9 g/ dl; at 1 month postandrogen: 9.2 ± 1.3 g/dl, p < 0.001; at 6 months: 10.7 ± 1.8 g/dl, p < 0.001). According to their response of serum erythropoietin the patients were divided into responders (15 patients) and nonresponders (10 patients). There were no differences between them concerning age, basal levels of serum erythropoietin and hemoglobin, and dose of nandrolone decanoate in relation to body weight. The evolution of hemoglobin was similar in both groups, and a correlation between serum erythropoietin and hemoglobin was not observed in the responder group. Fourteen patients were studied after androgen was discontinued. The serum erythropoietin returned to basal levels 6 weeks after the last dose of nandrolone decanoate (7.7 ± 5.4 mlU/ml). However, hemoglobin was above the basal levels 16 weeks after discontinuing androgen (9.5 ± 1.1 g/dl, p < 0.05), with no differences between the responder and nonresponder group. In conclusion, the hematopoietic effect of androgen in patients with chronic renal failure is independent of its action on the serum erythropoietin levels. The increase in the serum erythropoietin observed in 60% of patients is not the cause of the improvement in anemia and may be considered as an epiphenomenon.

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Section: Discussionmentioning

confidence: 99%

Evolution of Serum Erythropoietin after Androgen Administration to Hemodialysis Patients: A Prospective Study

Teruel

Marcén²,

Navarro³

et al. 1995

Nephron

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“…However, the use of androgens by athletes participating in endurance events such as long distance running and bicycling is not easily comprehensible because androgens have not been shown to improve endurance measures [36,37]. It is possible that the androgen-induced increments in hemoglobin may improve the oxygen carrying capacity of blood [38]. The speculation that androgens might allow the athletes to train harder by improving the regenerative response of the skeletal muscle to injury has not been tested rigorously.…”

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confidence: 99%

The physiological and pharmacological basis for the ergogenic effects of androgens in elite sports

Choong¹,

Lakshman²,

Bhasin³

2008

Asian J Andrology

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Androgen doping in power sports is undeniably rampant worldwide. There is strong evidence that androgen administration in men increases skeletal muscle mass, maximal voluntary strength and muscle power. However, we do not have good experimental evidence to support the presumption that androgen administration improves physical function or athletic performance. Androgens do not increase specific force or whole body endurance measures. The anabolic effects of testosterone on the skeletal muscle are mediated through androgen receptor signaling. Testosterone promotes myogenic differentiation of multipotent mesenchymal stem cells and inhibits their differentiation into the adipogenic lineage. Testosterone binding to androgen receptor induces a conformational change in androgen receptor protein, causing it to associate with beta-catenin and TCF-4 and activate downstream Wnt target genes thus promoting myogenic differentiation. The adverse effects of androgens among athletes and recreational bodybuilders are under reported and include acne, deleterious changes in the cardiovascular risk factors, including a marked decrease in plasma high-density lipoproteins (HDL) cholesterol level, suppression of spermatogenesis resulting in infertility, increase in liver enzymes, hepatic neoplasms, mood and behavioral disturbances, and long term suppression of the endogenous hypothalamic-pituitary-gonadal axis. Androgens are often used in combination with other drugs which may have serious adverse events of their own. In spite of effective methods for detecting androgen doping, the policies for screening of athletes are highly variable in different countries and organizations and even existing policies are not uniformly enforced.

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Androgens for the anaemia of chronic kidney disease in adults

Yang

Abudou

Xie³

et al. 2014

Cochrane Database of Systematic Reviews

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Prospective Controlled Study of Androgen Effects on Red Cell Oxygen Transport and Work Capacity in Chronic Hemodialysis Patients

Cited by 6 publications

References 17 publications

Evolution of Serum Erythropoietin after Androgen Administration to Hemodialysis Patients: A Prospective Study

Evolution of Serum Erythropoietin after Androgen Administration to Hemodialysis Patients: A Prospective Study

The physiological and pharmacological basis for the ergogenic effects of androgens in elite sports

Androgens for the anaemia of chronic kidney disease in adults

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