Prospective evaluation of associations between hearing sensitivity and selected cardiovascular risk factors

Fuortes, Laurence J.; Tang, Shenghui; Pomrehn, Paul R.; Anderson, Charlie

doi:10.1002/ajim.4700280211

Cited by 22 publications

(10 citation statements)

References 15 publications

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“…Inconsistent findings have been reported on the association between smoking and hearing loss. [3][4][5][6][7][8][9][10][11][12][13] The present finding of a dose-response relation at 4000 Hz indicates that smoking is a risk factor for high frequency hearing loss. Although the mechanism of the adverse effects of smoking on hearing is not clear, it is hypothesised that smoking may damage hair cells though an ischaemic mechanism-that is, by reducing blood flow to the cochlea or by increasing carboxyhaemogolobin.…”

Section: Discussionmentioning

confidence: 87%

“…Although countermeasures have successfully reduced noise levels in many industries, noise is still a common occupational hazard, and noise induced hearing loss is one of the major occupational diseases worldwide. 1 2 Evidence has accumulated in recent years on the adverse effects of smoking on hearing among the working population [3][4][5][6] as well as among the general population, 7 8 while the absence of such association has also been reported. [9][10][11][12][13] If smoking significantly increases the risk of hearing loss, hearing loss among workers may be treated as a work related impairment consisting, at least in part, of personal risk factors.…”

mentioning

confidence: 99%

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Combined effect of smoking and occupational exposure to noise on hearing loss in steel factory workers

Mizoue

Miyamoto²,

Shimizu³

2003

Occup Environ Med

119

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Background: Evidence has accumulated concerning the adverse effects of smoking on hearing acuity, but it is not clear whether smoking modifies the association between exposure to noise and hearing loss. Aims: To examine the synergistic effect of these variables on hearing. Methods: Data used were derived from periodic health examinations for 4624 steel company workers in Japan and included audiometry testing and information on smoking habits. Occupational exposure to noise was determined based on company records. Logistic regression was used to examine the dose-response association between smoking and hearing loss. The Cochran-Mantel-Haenszel method was used to calculate the prevalence rate ratio (PRR) of hearing loss for each combination of smoking and noise exposure factors, taking non-smokers not exposed to occupational noise as a reference. The interaction between smoking and noise exposure was assessed using a synergistic index, which equals 1 when the joint effect is additive. Results: Smoking was associated with increased odds of having high frequency hearing loss in a dose-response manner. The PRR for high frequency hearing loss among smokers exposed to occupational noise was 2.56 (95% CI 2.12 to 3.07), while the PRR for smokers not exposed to noise was 1.57 (95% CI 1.31 to 1.89) and the PRR for non-smokers exposed to noise was 1.77 (95% CI 1.36 to 2.30). The synergistic index was 1.16. Smoking was not associated with low frequency hearing loss. Conclusions: Smoking may be a risk factor for high frequency hearing loss, and its combined effect on hearing with exposure to occupational noise is additive.

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Section: Discussionmentioning

confidence: 87%

mentioning

confidence: 99%

Combined effect of smoking and occupational exposure to noise on hearing loss in steel factory workers

Mizoue

Miyamoto²,

Shimizu³

2003

Occup Environ Med

119

View full text Add to dashboard Cite

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“…When searching for future therapeutic interventions, we became interested in the reports from Barker and colleagues on the "Thrifty Phenotype Hypothesis" (Hales and Barker, 1992;Hales et al, 1997), which postulates that events during fetal life may cause adult disease. Such diseases sometimes coincide with those related to SNHL, for example coronary heart disease, hypertension, hyperlipidemia, and hypercholesterolemia (Axelsson and Lindgren, 1985;Fuortes et al, 1995;Garcia and Garcia, 1993;Pyykko et al, 1987Pyykko et al, , 1989Talbott et al, 1990;Tarter and Robins, 1990). If those risk factors for SNHL reXect confounding and not etiological mechanisms, and if new knowledge and ideas about future intervention strategies are to be found, then research must come closer to the causality.…”

Section: Introductionmentioning

confidence: 94%

The association between short stature and sensorineural hearing loss

2005

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“…Other non-genetic risk factors include: ototoxic medication [Aran et al, 1992;Boettcher et al, 1992;Stypulkowski, 1990], exposure to chemicals [Johnson and Nylen, 1995;Rybak, 1992], medical conditions such as diabetes [Kurien, 1989], cardiovascular disease [Gates et al, 1993], and renal failure [Antonelli, 1990]. A lot of controversy still exists on the relationship between tobacco smoking and ARHI [Brant, 1996;Fuortes et al, 1995;Gates et al, 1993;Mellstrom et al, 1982;Rosenhall, 1993].…”

Section: Introductionmentioning

confidence: 98%

KCNQ4: a gene for age-related hearing impairment?

et al. 2006

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Age-related hearing impairment (ARHI) is the most common sensory impairment among the elderly. It is a complex disorder influenced by genetic as well as environmental factors. SNPs in a candidate susceptibility gene, KCNQ4, were examined in two independent Caucasian populations. Two quantitative trait locus (QTL) values were investigated: Zhigh and Zlow, a measure of high and respectively low frequency hearing loss. In the first population, the statistical analysis of 23 genotyped SNPs spread across KCNQ4 resulted in significant p-values for two SNPs for Zhigh-SNP9 (NT_004511:g.11244177A > T) and SNP15 (NT_004511:g.11257005C > T; NP_004691:p.Ala259Ala), and one SNP for Zlow-SNP12 (NT_004511:g.11249550A > T). The linkage disequilibrium (LD) structure of KCNQ4 was subsequently determined in a 34-kb region surrounding the significant SNPs, resulting in three LD-blocks. LD-block 1 contains SNP9 and covers an area of 5 kb, LD-block 2 measures 5 kb and surrounds SNP13 (NT_004511:g.11253513A > G) to SNP18 (NT_004511:g.11257509G > A; NP_004691:p.Thr293Thr), and LD-block 3 spans 7 kb. Five tag-SNPs of block 1 and 2, and 2 extra SNPs were subsequently genotyped in the second population. Again, several SNPs were positively associated with ARHI: one SNP (SNP18) for the high frequencies and three SNPs (SNP9, SNP12, and SNP18) for the low frequencies, although only a single SNP (SNP12) resulted in significant p-values in both populations. Nevertheless, the associated SNPs of both populations were all located in the same 13-kb region in the middle of the KCNQ4 gene.

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Prospective evaluation of associations between hearing sensitivity and selected cardiovascular risk factors

Cited by 22 publications

References 15 publications

Combined effect of smoking and occupational exposure to noise on hearing loss in steel factory workers

Combined effect of smoking and occupational exposure to noise on hearing loss in steel factory workers

The association between short stature and sensorineural hearing loss

KCNQ4: a gene for age-related hearing impairment?

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