Prospective evaluation of C-reactive protein, smoking and lung cancer death in the Third National Health and Nutrition Examination Survey

Bittoni, Marisa; Focht, Brian C.; Clinton, Steven K.; Buckworth, Janet; Harris, Randall E.

doi:10.3892/ijo.2015.3141

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…CRP is an acute phase protein, which is produced in response to innate pro-inflammatory cytokines including IL-6 and IL-1 45,46 . Low level elevations of CRP have been shown to correlate with childhood exposure to parental neglect 47 and to be associated with increased risk of cardiovascular disease 48,49 and cancer 50 . Our results are in line with those of other studies which have examined a wider set of inflammatory markers 19,39–41 .…”

Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies

Layte

McCrory

Cheallaigh

et al. 2019

Sci Rep

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The status anxiety hypothesis proposes that systematic inflammation as a consequence of chronic psycho-social stress is a possible pathway linking socio-economic position (SEP) to premature ageing and is a possible explanation for cross-national variation in patterns of health and well-being. Harmonised data from the LIFEPATH consortium on 18,349 individuals aged 50 to 75 and 30,632 observations are used to measure variation in the association between inflammation measured as C-reactive protein and SEP across four countries (Britain, Ireland, Portugal and Switzerland) and five studies (ELSA, Whitehall II, TILDA, EPIPorto and SKIPOGH). Adjusting for population composition, mean concentrations of CRP are highest in Portugal, the country with the highest income inequality and lowest in Switzerland, a lower income inequality country. Across all of the studies, lower SEP groups have higher mean concentrations of CRP and, as predicted by the theory, absolute differentials between SEP groups reflect the pattern of societal income inequality. Adjustment for lifestyle indicators reduces SEP differentials by between 45% and 52% but cannot account for country variation in mean inflammation.

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Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies

Layte

McCrory

Cheallaigh

et al. 2019

Sci Rep

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“…There are consistent reports on plasma PLP as a predictor of cancer in the lungs 6,7 and other organs. 19 Plasma PLP is the most commonly used marker of vitamin B6 status, but plasma PLP concentrations are reduced by several factors linked to lung cancer carcinogenesis or progression, such as smoking, 21 inflammation measured as CRP [22][23][24] and increased level of alkaline phosphatase. 25 On the other hand, inflammation and elevated alkaline phosphatase (ALP) are not associated with impaired vitamin B6 availability in tissues.…”

Section: Hk:xa As a Marker Of Vitamin B6 Status And Predictor Of Lungmentioning

confidence: 99%

Impaired functional vitamin B6 status is associated with increased risk of lung cancer

Theofylaktopoulou

Midttun

Ueland

et al. 2018

Intl Journal of Cancer

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Circulating vitamin B6 levels have been found to be inversely associated with lung cancer. Most studies have focused on the B6 form pyridoxal 5'-phosphate (PLP), a direct biomarker influenced by inflammation and other factors. Using a functional B6 marker allows further investigation of the potential role of vitamin B6 status in the pathogenesis of lung cancer. We prospectively evaluated the association of the functional marker of vitamin B6 status, the 3-hydroxykynurenine:xanthurenic acid (HK:XA) ratio, with risk of lung cancer in a nested case-control study consisting of 5,364 matched case-control pairs from the Lung Cancer Cohort Consortium (LC3). We used conditional logistic regression to evaluate the association between HK:XA and lung cancer, and random effect models to combine results from different cohorts and regions. High levels of HK:XA, indicating impaired functional B6 status, were associated with an increased risk of lung cancer, the odds ratio comparing the fourth and the first quartiles (OR ) was 1.25 (95% confidence interval, 1.10-1.41). Stratified analyses indicated that this association was primarily driven by cases diagnosed with squamous cell carcinoma. Notably, the risk associated with HK:XA was approximately 50% higher in groups with a high relative frequency of squamous cell carcinoma, i.e., men, former and current smokers. This risk of squamous cell carcinoma was present in both men and women regardless of smoking status.

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“…Lung cancer is the leading cause of cancer-related death in both men and women worldwide (1), accounting for approximately 28% of all cancer deaths (2). In 2012, more than 1.8 million newly diagnosed lung cancer cases and about 1.6 million deaths were estimated (3).…”

Section: Introductionmentioning

confidence: 99%

Propofol inhibits lung cancer cell viability and induces cell apoptosis by upregulating microRNA-486 expression

Yang

Liang

Yang

et al. 2017

Braz J Med Biol Res

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Propofol is a frequently used intravenous anesthetic agent. Recent studies show that propofol exerts a number of non-anesthetic effects. The present study aimed to investigate the effects of propofol on lung cancer cell lines H1299 and H1792 and functional role of microRNA (miR)-486 in these effects. H1299 and/or H1792 cells were treated with or without propofol and transfected or not with miR-486 inhibitor, and then cell viability and apoptosis were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry. The expression of miR-486 was determined by quantitative real-time polymerase chain reaction (qRT-PCR) with or without propofol treatment. Western blot was performed to analyze the protein expression of Forkhead box, class O (FOXO) 1 and 3, Bcl-2 interacting mediator of cell death (Bim), and pro- and activated caspases-3. Results showed that propofol significantly increased the miR-486 levels in both H1299 and H1792 cells compared to untreated cells in a dose-dependent manner (P<0.05 or P<0.01). Propofol statistically decreased cell viability but increased the percentages of apoptotic cells and protein expressions of FOXO1, FOXO3, Bim, and pro- and activated caspases-3; however, miR-486 inhibitor reversed the effects of propofol on cell viability, apoptosis, and protein expression (P<0.05 or P<0.01). In conclusion, propofol might be an ideal anesthetic for lung cancer surgery by effectively inhibiting lung cancer cell viability and inducing cell apoptosis. Modulation of miR-486 might contribute to the anti-tumor activity of propofol.

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Prospective evaluation of C-reactive protein, smoking and lung cancer death in the Third National Health and Nutrition Examination Survey

Cited by 14 publications

References 34 publications

A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies

A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies

Impaired functional vitamin B6 status is associated with increased risk of lung cancer

Propofol inhibits lung cancer cell viability and induces cell apoptosis by upregulating microRNA-486 expression

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