Prospective evaluation of definitive chemoradiotherapy with volumetric
modulated arc therapy in patients with muscle invasive carcinoma of urinary bladder

Rastogi, Madhup; Gandhi, Ajeet Kumar; Tiwari, Raja; Nanda, Sambit Swarup; Rath, Satyajeet; Khurana, Rohini; Hadi, Rahat; Sapru, S.; Srivastava, Anoop Kumar; Dalela, Divakar

doi:10.5114/wo.2020.100275

2020

DOI: 10.5114/wo.2020.100275

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Prospective evaluation of definitive chemoradiotherapy with volumetric modulated arc therapy in patients with muscle invasive carcinoma of urinary bladder

Madhup Rastogi

Ajeet Kumar Gandhi

Raja Tiwari

et al.

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2024

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Follow-up strategies after trimodal treatment for muscle-invasive bladder cancer: a systematic review

Kaufmann,

Aeppli,

Arnold

et al. 2024

World J Urol

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Purpose Optimal follow-up strategies following trimodal treatment for muscle invasive bladder cancer play a crucial role in detecting and managing relapse and side-effects. This article provides a comprehensive summary of the patterns and risk factors of relapse, functional outcomes, and follow-up protocols. Methods A systematic literature search on PubMed and review of current guidelines and institutional follow-up protocols after trimodal therapy were conducted. Results Out of 200 identified publications, 43 studies (28 retrospective, 15 prospective) were selected, encompassing 7447 patients (study sizes from 24 to 728 patients). Recurrence rates in the urinary bladder varied between 14–52%; 3–16% were muscle-invasive while 11–36% were non-muscle invasive. Nodal recurrence occurred at 13–16% and distant metastases at 15–35%. After 5 and 10 years of follow-up, around 60–85% and 45–75% of patients could preserve their bladder, respectively. Various prognostic risk factors associated with relapse and inferior survival were proposed, including higher disease stage (> c/pT2), presence of extensive/multifocal carcinoma in situ (CIS), hydronephrosis, multifocality, histological subtypes, incomplete transurethral resection of bladder tumor (TURBT) and incomplete response to radio-chemotherapy. The analyzed follow-up guidelines varied slightly in terms of the number, timing, and types of investigations, but overall, the recommendations were similar. Conclusion Randomized prospective studies should focus on evaluating the impact of specific follow-up protocols on oncological and functional outcomes following trimodal treatment for muscle-invasive bladder cancer. It is crucial to evaluate personalized adaption of follow-up protocols based on established risk factors, as there is potential for improved patient outcomes and resource allocation.

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Follow-up strategies after trimodal treatment for muscle-invasive bladder cancer: a systematic review

Kaufmann,

Aeppli,

Arnold

et al. 2024

World J Urol

View full text Add to dashboard Cite

show abstract

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Prospective evaluation of definitive chemoradiotherapy with volumetric modulated arc therapy in patients with muscle invasive carcinoma of urinary bladder

Cited by 1 publication

References 33 publications

Follow-up strategies after trimodal treatment for muscle-invasive bladder cancer: a systematic review

Follow-up strategies after trimodal treatment for muscle-invasive bladder cancer: a systematic review

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