Prospective Evaluation of Focal High Intensity Focused Ultrasound for Localized Prostate Cancer

Focal therapy for localized prostate cancer – Current status

“…Only 5 major complications (all grade III) were noted in 4 patients. [ 11 ] Similar results were reported by previous small sized studies. [ 15 16 ] Stabile et al .…”

“…Eighty three percent of the patients had a negative in-field biopsy results and 13% had positive out of the field biopsy. [ 11 ] Urinary symptoms returned to the baseline at 3–6 months and the sexual function returned to the baseline at 12 months post treatment. Only 5 major complications (all grade III) were noted in 4 patients.…”

“…We perform 12 core template biopsies of the prostate in addition to 2 core MRI targeted biopsy of the suspicious lesion and while selecting patients for FT we include all grade groups, except those with NCCN very low risk or high risk with high volume PCa, defined as more than 2 cores positive for any Gleason Grade 4 or greater, as these patients are better suited for active surveillance and radical treatment, respectively. [ 11 ]…”

Can Low‐Intensity Pulsed Ultrasound Treat Discrete Pulmonary Lesions in Patients With COVID‐19?

“…However, US can also be used to induce a variety of biophysical effects with therapeutic intent, such as local thermal ablation of tissues by high‐intensity focused US, with intensities in the hundreds to thousands of watts per square centimeter, used for the treatment of prostate cancer 17 and neurologic disorders such as an essential tremor 18 . Between these diagnostic and therapeutic regimens lies the so called low‐intensity pulsed ultrasound (LIPUS) technique, in which a low US intensity is applied, with intensity typically less than 100 mW/cm 2 (ie, at the upper limit of diagnostic intensities) and up to 1 W/cm 2 .…”

This Month in Adult Urology

“…In this prospective study of focal high intensity focused ultrasound for patients with prostate cancer by Nahar et al (page 483) from Miami, Florida 52 patients had a minimum of 12-month followup. 7 Fifteen patients underwent pretreatment transurethral prostate resection or holmium laser enucleation of the prostate for debulking. Overall 83% who had posttreatment biopsies had negative in-field results while de novo out-of-field positive biopsies were found in 13%.…”