Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women

Sheu, Wayne Huey‐Herng; Chin, Huei-Min Linda; Lee, Wen‐Jane; Wan, Chu-Jen; Su, Hsiu-Yueh; Lang, Hui-Fen

doi:10.1016/j.lfs.2004.12.002

Cited by 22 publications

(12 citation statements)

References 33 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This might be indicating a change of dietary status. However; the folic acid level is declared as the main factor that can affect Hcy metabolism in great number of the researches [11,[15][16][17]19,21,23]. Our results supported these findings.…”

Section: Maximum Aerobic Capacitysupporting

confidence: 85%

“…It's thought that the increase in Hcy levels causes atherosclerosis and thrombosis through several ways [1,10,11,[18][19][20]. Physical activity, folic acid and/or vitamin B 6 -B 12 levels can influence Hcy methabolism [11,13,21]. Either an inefficiency of certain enzymes or a nutritional deficiency of the vitamins can lead to hyperhomocysteinemia [20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks

Subaşı

Gelecek²,

Aksakoğlu³

et al. 2012

Turk J Bioch

View full text Add to dashboard Cite

Section: Maximum Aerobic Capacitysupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks

Subaşı

Gelecek²,

Aksakoğlu³

et al. 2012

Turk J Bioch

View full text Add to dashboard Cite

“…Homocysteine concentration is significantly higher in hyper-insulinemic obese children than in the normo-insulinemic obese children [25]. Homocysteine levels are significantly lower after a 12-week weight loss program with dietary advice and light exercise in obese middle-aged women with high homocysteine levels at baseline [26]. In the present study, plasma levels of hs-CRP and homocysteine in obese children have decreased significantly after the weight reduction program.…”

Section: Discussionsupporting

confidence: 43%

The association of circulating interleukin-18 with fasting insulin and weight loss in obese children

Tso¹,

Huang²,

Chang³

2010

Health

View full text Add to dashboard Cite

Obesity is an independent risk factor for developing cardiovascular disease and increases insulin resistance in children. Interleukin (IL)-18 is a novel pro-inflammatory cytokine with potential atherogenetic properties. This study aimed to identify circulating levels of IL-18 in obese children and examine the effects of combined nutritional education-physical activity course on circulating IL-18. Plasma IL-18, body mass index (BMI), fasting glucose and insulin, homeostasis model assessment insulin resistance (HOMA IR), lipid profile, uric acid, highsensitive C-reactive protein (hs-CRP), and homocysteine were determined in 70 obese children aged 10-12 years before and after attending a 13-week weight reduction program, which included physical activities and nutritional education. Twenty-five age-matched non-obese children served as controls. At baseline, obese children had significantly higher levels of BMI, fasting insulin, HOMA IR, triglyceride (TG), uric acid, hs-CRP, and IL-18 but lower high-density lipoprotein-cholesterol (HDL-C) than non-obese children. Plasma IL-18 levels in obese children decreased significantly after the weight reduction program. At baseline, plasma IL-18 levels in obese children positively correlated with BMI, HOMA IR, insulin and TG but negatively correlated with HDL-C. There was a significant relationship between plasma IL-18 and BMI changes. Moreover, fasting insulin was responsible for IL-18 variability in obese children. These findings suggest that elevated plasma IL-18 levels in obese children are partly associated with parameters of obesity and insulin resistance, and are significantly affected by modest weight loss.

show abstract

“…A unique study in HIV-positive patients demonstrated that supplementary treatment with folate-vitamin B 12 complex was effective in reducing Hcy, both in patients with hyper-Hcy and in those with Hcy considered to be normal [14] . Other studies, conducted in HIVnegative patients, did not confi rm the useful role of nutrient supplementation in inducing Hcy normalization [15] , or normalization of Hcy-related hemostasis markers [16] , while another reported that smoking cessation would reduce plasma Hcy levels [17] . Lastly, another study conducted in a HIV-negative population demonstrated a signifi cant reduction of Hcy; however, this did not correlate with normalization of coagulation markers associated with cardiovascular risk [18] and impact on reduction of cardiovascular events has not been demonstrated yet [19] .…”

Section: Discussionmentioning

confidence: 98%

Influence of Folate Serum Concentration on Plasma Homocysteine Levels in HIV-Positive Patients Exposed to Protease Inhibitors Undergoing HAART

et al. 2006

View full text Add to dashboard Cite

Background: Homocysteinemia (Hcy) increase and risk factors in HIV-positive patients are not clear yet. Methods: HIV-positive patients on stable highly active antiretroviral therapy (HAART) regimens for at least 6 months were enrolled in this cross-sectional study. Among other factors, vitamin B₁₂, folate and length of exposure to protease inhibitors (PIs) were evaluated for their possible correlation with hyper-Hcy (>13 µmol/l in females; >15 µmol/l in males) by logistic regression analysis. Results: Ninety-eight HIV-positive patients were recruited. Twenty-eight (28.6%) had hyper-Hcy. Length of exposure to antiretroviral therapy and PIs did not result to be significantly associated with hyper-Hcy risk. Normal folate level was the only factor associated with the outcome, resulting protective from hyper-Hcy, either at univariate (OR = 0.22; CI 95% = 0.06–0.86; p = 0.029) and multivariable (OR = 0.24; CI 95% = 0.06–0.94; p = 0.04) logistic regression analysis. Folate predictive value of hyper-Hcy risk was driven by levels in the lowest quartiles of the study population (i.e. <10.9 nmol/l). Conclusions: No significant correlations were observed between hyper-Hcy and length of exposure to antiretroviral therapy or PIs. Folate could be a confounding factor in the association between hyper-Hcy and PI exposure found by others. The potential value of folate supplementation, in those who are deficient and in those with hyper-Hcy, merits study.

show abstract

Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: a randomized, double-blinded, placebo-controlled study in obese women

Cited by 22 publications

References 33 publications

Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks

Effects of two different exercise trainings on plasma homocysteine levels and other cardiovascular disease risks

The association of circulating interleukin-18 with fasting insulin and weight loss in obese children

Influence of Folate Serum Concentration on Plasma Homocysteine Levels in HIV-Positive Patients Exposed to Protease Inhibitors Undergoing HAART

Contact Info

Product

Resources

About