Prospective Evaluation of Intra-Articular Sodium Hyaluronate Injection in the Ankle

Murphy, Evelyn P.; Curtin, Mark; McGoldrick, Niall P; Thong, Gerard; Kearns, Stephen

doi:10.1053/j.jfas.2016.09.017

Cited by 27 publications

(14 citation statements)

References 39 publications

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“…Mean reductions from baseline in AOS score and the American Orthopedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Scale score (37,38) of 2.6 and 14 points, respectively, were reported 1 month after the most recent injection, with the same improvements at 6 months. The most recent of these studies assessed the impact of 3 injections of sodium hyaluronate in 50 participants with ankle OA (36). At 6 months posttreatment, statistically significant increases versus baseline in the mean Foot and Ankle Outcome Score values (39) were observed for all 5 domains (pain: 84 versus 48 points, p = .005).…”

Section: Discussionmentioning

confidence: 99%

Nonanimal Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: AProspective, Single-Arm Cohort Study

Younger

Penner

Wing

et al. 2019

The Journal of Foot and Ankle Surgery

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Ankle osteoarthritis (OA) can cause disabling symptoms, and some patients prefer to be treated with minimally invasive procedures. Nonanimal hyaluronic acid (NASHA) is a cross-linked hyaluronic acid product that has a prolonged intra-articular residence time. The authors report the first study of NASHA for the treatment of ankle OA. Thirtyseven patients with Kellgren-Lawrence grade II or III ankle OA received an intra-articular injection of NASHA (1 mL). Outcomes included visual analogue scale (VAS) scores for pain and disability. At baseline, the mean VAS pain score was 50.1 § 14.5 mm. During the 26-week follow-up period, the least squares (LS) mean change from baseline in the ankle OA VAS pain score was −20.5 mm (95% confidence interval [CI] ¡25.5 to ¡15.6 mm), an LS mean percentage reduction of 40.0% (95% CI 30.2% to 49.9%). The LS mean change from baseline in the VAS disability score during 26 weeks was ¡19.2 mm (95% CI ¡24.8 to ¡13.6 mm), a percentage reduction of 34% (95% CI 22.3% to 45.7%). Five participants experienced a total of 7 adverse events considered to be related to study treatment (injection site pain, n = 3; injection site joint pain, n = 3; plantar fasciitis, n = 1). This study shows promise for viscosupplementation with NASHA in the treatment of ankle OA. A single injection was associated with clinically meaningful reductions in pain and disability during a 26-week period and, in general, was well tolerated.

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Section: Discussionmentioning

confidence: 99%

Nonanimal Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: AProspective, Single-Arm Cohort Study

Younger

Penner

Wing

et al. 2019

The Journal of Foot and Ankle Surgery

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“…Имеются данные о возможности использования ГлК при лечении ОА голеностопного сустава [75][76][77]. Оценка применения ГлК при этой локализации ОА была проведена T.В.…”

Section: рис 1 механизм действия экзогенной глкunclassified

Hyaluronic acid preparations in the treatment of osteoarthritis: is it clear to us?

Каратеев¹,

Погожева²,

Амирджанова³

et al. 2018

RJTAO

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Osteoarthritis (OA) is a progressive joint disease that causes persistent pain, limited joint function, disability, and loss of social activity. One of the most popular OA treatment options is intra-articular (I/A) hyaluronic acid (HA) injections. This procedure was introduced into clinical practice in the early 1980s and is used universally. To date, there is no consensus on the therapeutic value of HA. Many investigations confirm that HA is effective as not only a symptomatic agent, but also a structure-modifying one. Some works also show that the effect of HA is equal or only slightly superior to that of placebo (I/A saline injection). The review describes the mechanism of action and comparative efficacy of various (lowand high-molecular weight) HA preparations, as well as the safety of their use in real clinical practice.

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“…Cartilage tissues play important roles over all the human body. They lubricate the joints and distribute the compressive forces to minimize stresses on the subchondral bone . Unfortunately, repetitive impact and twisting due to daily physical activities of the human body may lead to the damage of the articular cartilage and the joint surfaces of the knee.…”

Section: Introductionmentioning

confidence: 99%

“…They lubricate the joints and distribute the compressive forces to minimize stresses on the subchondral bone. [1][2][3][4] Unfortunately, repetitive impact and twisting due to daily physical activities of the human body may lead to the damage of the articular cartilage and the joint surfaces of the knee. An injury affecting the articular cartilage can result in pain, swelling, joint dysfunction, and progressive degeneration of the joints, such as osteoarthritis that affects a large number of patients worldwide, being responsible for over 67 % of hospitalization.…”

Section: Introductionmentioning

confidence: 99%

“…An injury affecting the articular cartilage can result in pain, swelling, joint dysfunction, and progressive degeneration of the joints, such as osteoarthritis that affects a large number of patients worldwide, being responsible for over 67 % of hospitalization. [1] Unlike other tissues, cartilage has a limited capacity for regeneration. Therefore, once injured, it has more difficulties healing itself due to the low chondrocyte density, the dense extracellular matrix, and the absence of tissue vascularization.…”

Section: Introductionmentioning

confidence: 99%

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Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

et al. 2018

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The purpose of this study was to improve the biocompatibility of glutaraldehyde (GA) cross‐linked chitosan coated collagen scaffold for cartilage tissue regeneration. In order to prevent the potential toxicity of GA, we treated the designed scaffold with either glutamic acid or glycine. Amino acid treated scaffolds were characterized by scanning electron microscopy (SEM) techniques. Afterward, chondrocyte interaction with the composite scaffold was investigated assessing cell adhesion and proliferation using Hoechst staining and MTT cell proliferation assay, respectively. The SEM analyses of the scaffolds’ surface and cross‐section confirmed the adhesion of amino acids on the surface of the scaffolds. We also observed that scaffolds’ porosity was reduced due to the coverage of the pores by chitosan and amino acids, leading to low porosity. The use of amino acid improved the chondrocyte adhesion and proliferation inside the scaffolds’ pores when cells were cultured onto the chitosan‐coated collagen scaffolds. Overall, our in vitro results suggest the use of amino acid to improve the biocompatibility of natural polymer composite scaffold being crosslinked with glutaraldehyde. Such scaffold has improved mechanical properties; biocompatibility thus may be useful for tissue regeneration such as cartilage.

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Prospective Evaluation of Intra-Articular Sodium Hyaluronate Injection in the Ankle

Cited by 27 publications

References 39 publications

Nonanimal Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: AProspective, Single-Arm Cohort Study

Nonanimal Hyaluronic Acid for the Treatment of Ankle Osteoarthritis: AProspective, Single-Arm Cohort Study

Hyaluronic acid preparations in the treatment of osteoarthritis: is it clear to us?

Surface treatment with amino acids of porous collagen based scaffolds to improve cell adhesion and proliferation

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