Prospective evaluation of multiparametric ultrasound and quantitative elastosonography in the differential diagnosis of benign and malignant thyroid nodules: Preliminary experience

Cantisani, Vito; D’Andrea, Vito; Biancari, Fausto; Medvedyeva, Olena; Segni, Mattia Di; Olive, M.; Patrizi, Gregorio; Redler, Adriano; E, Enrico De Antoni; Masciangelo, Raffaele; Frezzotti, Francesca; Ricci, Paolo

doi:10.1016/j.ejrad.2011.11.056

Cited by 97 publications

(93 citation statements)

References 16 publications

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“…Realtime elastography (RTE) a qualitative method has been evaluated in a number of studies [8][9][10][11][12][13][18][19][20]. A recent meta-analysis performed by Bojunga et al [13] summarizes the results of several studies reporting a global sensitivity and specificity of 92 and 90 %, respectively, for RTE in the diagnosis of malignant thyroid nodules.…”

Section: Discussionmentioning

confidence: 99%

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Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

et al. 2014

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Purpose The aim of this study is to assess the diagnostic efficacy and interobserver agreement of acoustic radiation force impulse (ARFI) elasticity imaging in differentiating thyroid nodules. Methods In our study, 74 consecutive patients (52 females, 22 males; age range 27-77 years, mean: 41 years) with 82 thyroid nodules (60 benign nodules, and 22 malignant) were examined by two radiologists with different experience. Patients underwent either cytology using fine needle aspiration cytology or thyroid surgery. The diagnostic performance of the two operators at ARFI with sensitivity, specificity, positive predictive and negative predictive value, and ROC curves was estimated. Interreader variability between the two operators was defined using Cohen's k.Results According to receiver operating characteristics ROC curves (AUROC = 0.86 for observer 1; 0.81 for observer 2) sensitivity, specificity, PPV and NPV of reader 1 and 2 were respectively: 90, 75, 90.91 and 96.55 %; (cutoff value of shear wave: 2.455 m/s); 90, 72, 90 and 96.90 % (cut-off value shear wave: 2.365 m/s). Concordance between the two operators was good (k = 0.755). Conclusions This work is a feasibility study evaluating ARFI imaging. Its results suggest that ARFI imaging is a reproducible method which can be utilized with good diagnostic performance in the thyroid for discriminating benign and malignant nodules using the cut-off value of 2.455 m/s. However, larger studies are needed to validate this method.Keywords Acoustic radiation force impulse (ARFI) Á Elastography Á Benign thyroid nodules Á Malignant thyroid nodules Á Ultrasound Riassunto Scopo Lo scopo di questo studio è la valutazione della efficacia diagnostica e della concordanza inter-osservatore dell'imaging elastografico ARFI, per la differenziazione di noduli tiroidei. Metodo Nel nostro studio, 74 pazienti consecutivi (52 femmine, 22 maschi; range di età 22-77 anni, età media 41 anni) con 82 noduli tiroidei (60 noduli benigni e 22 maligni), sono stati esaminati da due radiologi con diverso livello di esperienza. I pazienti sono stati sottoposti o a citologia aspirativa con ago sottile (FNAC), o a chirurgia tiroidea. La performance diagnostica dei due operatori all' ARFI è stata stimata con la sensibilità, la specificità, il valore predittivo positivo (VPP) e negativo (VPN), attraverso le curve ROC (receiver operating characteristics). La variabilità inter-osservatore tra i due operatori, è stata definita usando la kappa di Cohen. (2014( ) 17:13-20 DOI 10.1007 Risultati Secondo le curve ROC (AUROC = 0.86 per il primo osservatore; 0.81 per il secondo osservatore) la sensibilità, la specificità, il VPP e il VPN per gli osservatori 1 e 2, erano rispettivamente: 90, 75, 90,91, e 96.55 %; (valore medio di shear wave: 2.455 m/s); 90, 72, 90 e 96.90 % (valore medio di shear wave: 2.365 m/s). La concordanza tra I due operatori era buona (k = 0.755). Conclusioni Questo lavoro è uno studio preliminare che valuta l'imaging elastografico con Acustic Radiation Force Impulse. I risultati sug...

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Section: Discussionmentioning

confidence: 99%

“…Qualitative and semi-quantitative elastosonography methods have been evaluated in a variety of studies on the thyroid with promising results [8][9][10][11][12]. A meta-analysis of eight studies, yielded a mean sensitivity of 92 % and mean specificity of 90 % [13].…”

Section: Introductionmentioning

confidence: 99%

Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

et al. 2014

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“…Micro-calcification, not containing a cystic component and heterogeneous internal structure have been reported as important USG findings in the diagnosis of thyroid carcinoma in many studies (9,10). In our study, the comparison of pre-operative USG findings and main specimen pathology results revealed a significantly higher risk of malignancy in solid hypo echoic nodules compared to others (11)(12)(13)(14). Furthermore, it was observed that as the solid component of the nodule increases (mixed echogenicity), the risk of malignancy increases.…”

Section: Discussionmentioning

confidence: 51%

Thyroid Masses: An Analysis of 135 Cases

Şengül¹,

Yılmaz²,

Özbay³

et al. 2016

Acta Med Anatol

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“…In another more recent study on 97 patients, the prediction of malignancy using strain ratio with cut-off value ≥2, sensitivity, specificity, PPV, and NPV of 97.3%, 91.7%, 87.8%, and 98.2% was obtained [7]. Strain index value greater than 4 on off-line processed elastograms was the strongest independent predictor of thyroid gland malignancy, with 96% specificity and 82% sensitivity.…”

Section: Malignant Thyroid Nodulesmentioning

confidence: 99%

“…To avoid false results at elastography, a macrocalcification must be excluded from the region of interest (ROI), as its stiffness alters the nodules stiffness assessment [7].…”

Section: Cysts and Pseudocystsmentioning

confidence: 99%

Thyroid Ultrasound: State of the Art. Part 2 – Focal Thyroid Lesions

et al. 2017

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Accurate differentiation of focal thyroid nodules (FTL) and thyroid abnormalities is pivotal for proper diagnostic and therapeutic work-up. In these two part articles, the role of ultrasound techniques in the characterization of FTL and evaluation of diffuse thyroid diseases is described to expand on the recently published World Federation in Ultrasound and Medicine (WFUMB) thyroid elastography guidelines and review how this guideline fits into a complete thyroid ultrasound exam.

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Prospective evaluation of multiparametric ultrasound and quantitative elastosonography in the differential diagnosis of benign and malignant thyroid nodules: Preliminary experience

Cited by 97 publications

References 16 publications

Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

Prospective evaluation of acoustic radiation force impulse technology in the differentiation of thyroid nodules: accuracy and interobserver variability assessment

Thyroid Masses: An Analysis of 135 Cases

Thyroid Ultrasound: State of the Art. Part 2 – Focal Thyroid Lesions

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