Prospective evaluation of quality of life in patients with head and neck cancer

Oliveira, Rogéria Lucio de; Santos, Rafaelle Ferreira Dos; Carvalho, Sérgio Henrique Gonçalves De; Agripino, Gustavo Gomes; Canto, Marcela Maria Nery; Carvalho, Marianne de Vasconcelos; Marinho, Sandra Aparecida; Gallottini, Marina; Sarmento, Dmitry José de Santana

doi:10.1016/j.oooo.2016.11.021

Cited by 9 publications

(5 citation statements)

References 32 publications

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“…While the primary goal of therapy is cure, speech and swallowing function is of critical importance as well. Swallowing impairment is very common in this patient population before, during, and after treatment, leading to worse overall quality of life 7‐12 . Dysphagia following total laryngectomy is attributed to stricture, diverticula, reduced transit in the neopharynx, and reflux 8,13 .…”

Section: Introductionmentioning

confidence: 99%

Reconstruction technique following total laryngectomy affects swallowing outcomes

Harris

Hoshal

Evangelista

et al. 2020

Laryngoscope Investig Oto

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Objectives How reconstruction affects function following total laryngectomy is unclear. This study seeks to determine whether reconstruction method is associated with differences in swallowing outcomes. Methods Retrospective review of reconstruction technique in patients undergoing TL was compared by pharyngeal transit time (PTT), patient‐reported dysphagia (EAT‐10), and diet‐tolerated (FOIS). Results Ninety‐five patients met inclusion criteria, with 40 patients (42.1%) undergoing primary closure and 55 patients (57.9%) undergoing tissue transfer. There was no difference in EAT‐10 scores between the groups (P = .09). There was a significantly higher proportion of patients achieving oral diet (FOIS >3) with primary closure (P = .003). Patients undergoing PMC vs free flap had similar rates of g‐tube dependency. Primary closure had the shortest PTT (1.89 seconds) compared to free flap (3.47‐4.65 seconds) or PMC (5.1 seconds; P = .035). Conclusions When primary closure is achievable, these results suggest improved swallowing outcomes with better tolerance of oral diet and shorter pharyngeal transit times. Level of evidence IV

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Section: Introductionmentioning

confidence: 99%

Reconstruction technique following total laryngectomy affects swallowing outcomes

Harris

Hoshal

Evangelista

et al. 2020

Laryngoscope Investig Oto

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“…Most of studies on HRQOL in HNC patients have investigated different time points, for example three months, six months and a year after treatment [ 13 – 16 ]. Thus, studies evaluating this context in short-term are still scarce.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Lima

Ferreira

Lajolo

et al. 2020

Health Qual Life Outcomes

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Background Quality of life (QoL) is influenced in head and neck cancer (HNC) patients by a set of factors related to diagnosis, treatment and tumor impacts. The aim of this study was to evaluate the Quality of Life (QoL) changes in Head and Neck cancer (HNC) patients during treatment (radiotherapy and/or chemoradiotherapy). Methods QoL was evaluated prospectively in 63 HNC patients during radiotherapy and/or chemoradiotherapy at three moments: before or at beginning (T0), in the middle (T1 ~ four weeks) and immediately at the end (T2 ~ eight weeks) of treatment. The differences between the scores at different time points was verified using Friedman’s non-parametric test. Negative changes between time points were evaluated, with differences (delta) of ±10 points being considered to be clinically significant. Results The total mean age was 59.1 ± 9.5y, and 82.5% were male. The oral cavity and larynx were more frequent tumors. The functional score for ‘role’ was decreased at time points T1 and T2 as compared to T0, while an improvement in scores was observed for cognitive function. Several physical symptoms also worsened over time, such as: fatigue, nausea and vomiting, dry mouth and sticky saliva, swallowing and skin symptoms, senses and teeth problems. A high frequency of altered and clinically meaningful values were observed for most of domains, ranging from 6 to 74%. Conclusions The QoL became worse at approximately one month after treatment beginning in HNC patients, and this remained until the end of therapy. Protocols directing to early nutritional counseling and management of symptoms of nutritional impact are important to improve clinical outcomes. This is part of preventive actions aiming to make the exhausting treatment process less traumatic and easier to complete.

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“…The sample size was calculated based on the results of a previous study in which mean UW-QOL scores of individuals with early (I/II) and advanced (III/IV) stage cancer were 1056.84 (SD: 126.85) and 912.50 (SD: 222.38), respectively. 12 Considering a 95% confidence interval, 90% power, 1:1 ratio between unexposed and exposed individuals, and the addition of 20% to compensate for possible losses, the minimum sample size was 85 individuals.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…In addition to assessing each of the 12 domains individually, the questionnaire also allows an integrated evaluation based on the mean or sum, with higher scores denoting better QoL. 12,14 To measure and qualify SOC, the patients answered the short version of the 13-item Sense of Coherence (SOC-13) scale, which was originally developed by Antonovsky 2 and was subsequently translated, adapted, and validated for use in Brazil. 15 The questions are divided into three components: comprehensibility, manageability, and meaning.…”

Section: Variablesmentioning

confidence: 99%

Effect of the sense of coherence and associated factors in the quality of life of head and neck cancer patients

et al. 2020

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Prospective evaluation of quality of life in patients with head and neck cancer

Cited by 9 publications

References 32 publications

Reconstruction technique following total laryngectomy affects swallowing outcomes

Reconstruction technique following total laryngectomy affects swallowing outcomes

Health-related quality of life became worse in short-term during treatment in head and neck cancer patients: a prospective study

Effect of the sense of coherence and associated factors in the quality of life of head and neck cancer patients

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