Prospective evaluation of risk factors of cutaneous drug reactions to sulfonamides in patients with AIDS

Eliaszewicz, M.; Flahault, Antoine; Roujeau, Jean‐Claude; Fillet, Anne Marie; Challine, Dominique; Mansouri, Samira; Wolkenstein, Pierre; Aractingi, S.; Penso-Assathiany, D.; Maslo, Caroline; Bourgault‐Villada, Isabelle; Chosidow, Olivier; Caumes, Éric

doi:10.1067/mjd.2002.120468

Cited by 67 publications

(51 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The number of CD4 + cells is a good marker of disease progression and is low in AIDS patients. Prospective evaluation of risk factors for cutaneous drug eruptions in patients with AIDS revealed that high CD8 + cell numbers indicated a risk of drug eruption [22]. Our mouse model demonstrated that thymus-derived CD4 + CD25 + regulatory T cells can prevent severe epidermal damage induced by autoreactive CTL, and that aberration of the immune system of our mice (i.e.…”

Section: Discussionmentioning

confidence: 88%

Prevention of toxic epidermal necrolysis by regulatory T cells

et al. 2005

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 88%

Prevention of toxic epidermal necrolysis by regulatory T cells

et al. 2005

View full text Add to dashboard Cite

“…The incidence of drug eruption significantly increases with decreasing CD4 + T cells counts and CD4/CD8 ratio, as well as increasing age. Particularly, the incidence of severe adverse drug reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is thousandfold higher in patients with AIDS than in the general population [18,19]. No satisfactory explanation for this phenomenon has been advanced, but there is indirect evidence that this results from an increase in the incidence of viral infections and an increased use of certain drugs.…”

Section: Stevens-johnson Syndrome and Viral Infectionsmentioning

confidence: 96%

A Complex Interaction Between Drug Allergy and Viral Infection

Shiohara

Kano

2007

Clinic Rev Allerg Immunol

169

110

View full text Add to dashboard Cite

A relationship between viral infections and the simultaneous or subsequent development of drug rashes has been observed in a number of clinical situations. We have recently provided evidence to indicate an intimate relationship between reactivation of human herpesvirus 6 (HHV-6) and the development of a severe systemic hypersensitivity reaction referred to as drug-induced hypersensitivity syndrome (DIHS). This syndrome has several unique features that cannot be explained by a drug etiology; they include its delayed onset, paradoxical worsening of clinical symptoms after discontinuation of the causative drugs, and a step-wise development of several organ system failures long after clinical resolution. Many aspects of this syndrome suggest close similarities between DIHS and graft-versus-host disease (GVHD). Indeed, a wide variety of complications frequently occurring in GVHD, such as autoimmune diseases, is often observed during the course of this syndrome and even long after clinical resolution. Our recent studies have shown that in DIHS sequential reactivations of several herpesviruses (HHV-6, HHV-7, Epstein-Barr virus, and cytomegalovirus) can be detected coincident with various clinical symptoms in the same order as demonstrated in GVHD. Thus, not only the timing but also the order in which these herpesviruses can be reactivated in the host would be crucial determinant of outcomes of the disease. Our results indicate the importance of recognizing DIHS and other drug rashes associated with viral infections at risk of eventually developing autoimmune diseases.

show abstract

“…The use of anti-infectious sulfonamides is complicated by the unusually high rate of cutaneous drug reactions (CDR) (Eliaszewicz et al, 2002). Theoretically, variation in the bioactivation of sulfonamides and the detoxification of the hydroxylamine and nitroso-may determine this susceptibility (van der Ven et al, 1991).…”

Section: Association Analysis Of Drug Metabolizing Enzyme Gene Polymomentioning

confidence: 99%