Prospective evaluation of the effect of ionizing radiation on the bladder tumor-associated (BTA) urine test

Crane, Christopher H.; Clark, Maureen M.; Bissonette, Eric A.; Theodorescu, Dan

doi:10.1016/s0360-3016(98)00380-0

Cited by 5 publications

(4 citation statements)

References 10 publications

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“…In addition, some tests for invasive bladder cancer, e.g. urinary cytology [19] and the bladder tumour antigen test [20], can be falsely positive in the setting of RT, making those tests difficult to interpret.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of bladder cancer in patients previously treated with radiation for prostate cancer

Sandhu¹,

Vickers

Bochner³

et al. 2006

BJU International

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clinical stage, initial pathology, definitive therapy, definitive pathological stage, and disease status were recorded. RESULTSIn all, 100 patients were identified who had a diagnosis of bladder cancer after a diagnosis of prostate cancer between January 1992 and August 2003; 58 had had RT for prostate cancer. The mean time between a diagnosis of bladder cancer and prostate cancer was 62 months in the RT group and 34 months in the unirradiated group ( P = 0.002) At diagnosis of bladder cancer, 56 (97%) of the patients who received RT had high-grade urothelial carcinoma, vs 27 (64%) of those not irradiated ( P < 0.001). Thirty (52%) of the patients with RT had muscle-invasive bladder cancer, vs 17 (40%) of those not irradiated ( P = 0.3). The survival rate was similar for both groups. CONCLUSIONSBladder cancer is diagnosed later, and is of higher grade, in patients who are irradiated for prostate cancer than in those treated with other methods. Patients with prostate cancer who are treated with RT should be monitored closely for the presence of bladder cancer.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of bladder cancer in patients previously treated with radiation for prostate cancer

Sandhu¹,

Vickers

Bochner³

et al. 2006

BJU International

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“…No accurate data were available for tumour size. All patients had sterile urine preoperatively and no history of genitourinary inflammatory conditions or recent radiotherapy [23] to the urinary tract. All patients with muscle‐invasive disease had staging imaging studies including CT of the abdomen and pelvis, with oral and intravenous contrast medium, or MRI of the abdomen and pelvis with oral and intravenous contrast medium, and either a chest X‐ray or CT of the chest.…”

Section: Methodsmentioning

confidence: 99%

A prospective pilot evaluation of urinary and immunohistochemical markers as predictors of clinical stage of urothelial carcinoma of the bladder

Krupski¹,

Moskaluk²,

Boyd

et al. 2000

BJU International

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“…In addition some tests for invasive bladder cancer, e.g. urinary cytology and the bladder tumor antigen test, can be falsely positive in the setting of radiation therapy, making those tests difficult to interpret [Crane et al 1999;Wiggishoff and McDonald, 1972].…”

Section: Therapeutic Advances In Urology 2 (3)mentioning

confidence: 99%

Secondary malignancies following radiotherapy for prostate cancer

Sountoulides

Koletsas

Kikidakis

et al. 2010

Therapeutic Advances in Urology

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Human exposure to sources of radiation as well as the use of radiation-derived therapeutic and diagnostic modalities for medical reasons has been ongoing for the last 60 years or so. The carcinogenetic effect of radiation either due to accidental exposure or use of radiation for the treatment of cancer has been undoubtedly proven during the last decades. The role of radiation therapy in the treatment of patients with prostate cancer is constantly increasing as less-invasive treatment modalities are sought for the management of this widely, prevalent disease. Moreover the wide adoption of screening for prostate cancer has led to a decrease in the average age that patients are diagnosed with prostate cancer. Screening has also resulted in the diagnosis of low-grade, less-aggressive prostate cancers which would probably never lead to complications or death from the disease. Radiotherapy for prostate cancer has been linked to the late occurrence of second malignancies both in the true pelvis and outside the targeted area due to low-dose radiation scatter. Secondary malignancies following prostate irradiation include predominantly bladder cancer and, to a lesser extent, colon cancer. Those secondary radiation-induced bladder tumors are usually aggressive and sometimes lethal. Care should be given to the long-term follow up of patients under radiation therapy for prostate cancer, while the indications for its use in certain cases should be reconsidered.

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Prospective evaluation of the effect of ionizing radiation on the bladder tumor-associated (BTA) urine test

Cited by 5 publications

References 10 publications

Clinical characteristics of bladder cancer in patients previously treated with radiation for prostate cancer

Clinical characteristics of bladder cancer in patients previously treated with radiation for prostate cancer

A prospective pilot evaluation of urinary and immunohistochemical markers as predictors of clinical stage of urothelial carcinoma of the bladder

Secondary malignancies following radiotherapy for prostate cancer

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