Prospective Follow-Up of Adolescents With and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort Longitudinal Assessments

Piccin, Jader; Viduani, Anna; Buchweitz, Claudia; Pereira, Rivka B.; Zimerman, Aline; Amando, Guilherme R.; Cosenza, Victor; Ferreira, Leonardo Z.; McMahon, Natália A.G.; Melo, Ramásio F.; Richter, Danyella; Reckziegel, Frederico D.S.; Rohrsetzer, Fernanda; Souza, Laila; Tonon, André C.; Costa-Valle, Marina Tuerlinckx; Zajkowska, Zuzanna; Araújo, Ricardo Matsumura; Hauser, Tobias U.; van Heerden, Alastair; Hidalgo, Maria Paz; Kohrt, Brandon A.; Mondelli, Valeria; Swartz, Johnna R.; Fisher, Helen L.; Kieling, Christian

doi:10.1016/j.jaacop.2023.11.002

JAACAP Open

2024

DOI: 10.1016/j.jaacop.2023.11.002

|View full text |Cite

Prospective Follow-Up of Adolescents With and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort Longitudinal Assessments

Jader Piccin,

Anna Viduani,

Claudia Buchweitz

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study

Zonca,

Marizzoni,

Saleri

et al. 2024

Transl Psychiatry

Self Cite

View full text Add to dashboard Cite

The biological mechanisms underlying the onset of major depressive disorder (MDD) have predominantly been studied in adult populations from high-income countries, despite the onset of depression typically occurring in adolescence and the majority of the world’s adolescents living in low- and middle-income countries (LMIC). Taking advantage of a unique adolescent sample in an LMIC (Brazil), this study aimed to identify biological pathways characterizing the presence and increased risk of depression in adolescence, and sex-specific differences in such biological signatures. We collected blood samples from a risk-stratified cohort of 150 Brazilian adolescents (aged 14–16 years old) comprising 50 adolescents with MDD, 50 adolescents at high risk of developing MDD but without current MDD, and 50 adolescents at low risk of developing MDD and without MDD (25 females and 25 males in each group). We conducted RNA-Seq and pathway analysis on whole blood. Inflammatory-related biological pathways, such as role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza (z-score = 3.464, p < 0.001), interferon signaling (z-score = 2.464, p < 0.001), interferon alpha/beta signaling (z-score = 3.873, p < 0.001), and complement signaling (z-score = 2, p = 0.002) were upregulated in adolescents with MDD compared with adolescents without MDD independently from their level of risk. The up-regulation of such inflammation-related pathways was observed in females but not in males. Inflammatory-related pathways involved in the production of cytokines and in interferon and complement signaling were identified as key indicators of adolescent depression, and this effect was present only in females.

show abstract

Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study

Zonca,

Marizzoni,

Saleri

et al. 2024

Transl Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Prospective Follow-Up of Adolescents With and at Risk for Depression: Protocol and Methods of the Identifying Depression Early in Adolescence Risk Stratified Cohort Longitudinal Assessments

Cited by 1 publication

References 79 publications

Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study

Inflammation and immune system pathways as biological signatures of adolescent depression—the IDEA-RiSCo study

Contact Info

Product

Resources

About