Prospective longitudinal evaluation of lung function during the first year of life after extracorporeal membrane oxygenation*

Hofhuis, Ward; Hanekamp, Manon; IJsselstijn, Hanneke; Nieuwhof, Eveline M.; Hop, Wim C. J.; Tibboel, Dick; Jongste, Johan C. de; Merkus, Peter

doi:10.1097/pcc.0b013e3181e8946e

Cited by 23 publications

(21 citation statements)

References 29 publications

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“…However, few CDH patients were included in this studied population of 106 subjects [22]. HOFHUIS et al [10] found below-average but normal lung volumes and stable forced expiratory flows during the first year of life in 64 infants following ECMO. At 12 months, only the CDH patients showed signs of hyperinflation with plethysmographic FRC significantly above normal.…”

Section: Other Determinants Of Lung Function Parametersmentioning

confidence: 99%

“…ECMO was initiated in case of reversible severe respiratory failure and an estimated mortality risk of higher than 80% using the entry criteria of STOLAR et al [11]. We have previously reported our entry criteria and exclusion criteria and these did not change during the study period [10]. The study was embedded in a structured prospective post-ECMO follow-up programme initiated in 2001 that provides for regular assessments of lung function, growth and developmental parameters until 18 yrs of age [12].…”

Section: Participantsmentioning

confidence: 99%

“…Before bronchodilation, mean SDS FEV1 and SDS FVC were negatively influenced by duration of ventilation (both parameters p,0.001), duration of ECMO support (pf0.001 for both parameters), and the presence of CLD (both pf0.001). Both parameters were positively correlated to birth weight (both Long-term pulmonary function abnormalities, such as hyperinflation and airway obstruction, are well recognised after neonatal respiratory failure secondary to lung injury from MAS, CDH and neonatal pneumonia [10,[19][20]. Treatment modalities such as supplemental oxygen and mechanical ventilation contribute to the pathogenesis of CLD [21].…”

Section: Other Determinants Of Lung Function Parametersmentioning

confidence: 99%

“…The long-term pulmonary sequelae of neonatal ECMO have hardly been studied. Crosssectional studies during or shortly after ECMO all reported reduced lung function, perhaps due to severity of the underlying respiratory disease [6][7][8][9][10].…”

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confidence: 99%

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Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation

et al. 2012

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The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and to identify any effects of diagnosis and perinatal characteristics.121 neonatal ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with other diagnoses) performed a total of 191 lung function measurements at 5, 8 and/or 12 yrs. We assessed dynamic and static lung volumes, reversibility of airway obstruction and diffusion capacity.Mean SDS forced expiratory volume in 1 s (FEV1) at 5 yrs before and after bronchodilation (-0.51 and 0.07) was significantly higher than at 8 (-0.79 and -0.4; p,0.04) and 12 yrs (-1.10 and -0.52; p,0.003). Mean SDS for all spirometric parameters before and after bronchodilation were significantly lower in the congenital diaphragmatic hernia group compared with the other diagnostic groups (all pf0.025). A significant volume of trapped air was observed in 86% patients with congenital diaphragmatic hernia, 50% with meconium aspiration syndrome and 58% with other diagnoses. After bronchodilation, mean SDS FEV1 and forced vital capacity were negatively influenced by duration of ventilation (both p,0.001) and duration of ECMO (p50.003 and p50.02, respectively).Long-term pulmonary sequelae after neonatal ECMO-treatment mainly occur in congenital diaphragmatic hernia patients and tend to deteriorate over time.

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Section: Other Determinants Of Lung Function Parametersmentioning

confidence: 99%

Section: Participantsmentioning

confidence: 99%

Section: Other Determinants Of Lung Function Parametersmentioning

confidence: 99%

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Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation

et al. 2012

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“…Entry criteria and exclusion criteria were previously described by our group (18) and did not change during the study period. Cerebral ultrasound examinations were performed prior to treatment with ECMO, daily during ECMO treatment, and before discharge from our hospital.…”

Section: Participantsmentioning

confidence: 99%

Sensorineural Hearing Loss and Language Development Following Neonatal Extracorporeal Membrane Oxygenation

Hondel

Madderom

Goedegebure

et al. 2013

Pediatric Critical Care Medicine

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OBJECTIVE:To determine the prevalence of hearing loss in school-age children who have undergone neonatal extracorporeal membrane oxygenation (ECMO) treatment and to identify any effects of hearing loss on speech-and language development. DESIGN:Prospective longitudinal follow-up study within the framework of a structured post-ECMO follow-up program.SETTING: Outpatient clinic of a level III university hospital. RESULTS:Tone audiometry was performed by standardized protocol in 136 children aged 5 to 12 years. Hearing loss was considered clinically significant when >20dB. Hearing was normal in 75.7% of children. Five children (3.7%) had bilateral sensorineural or combined hearing loss; 3 of them received special audiological care (2.2% of total sample). Of the 24 children with congenital diaphragmatic hernia, 19 (79.2%) had normal hearing; and only 2 (8.3%) had mild SNHL, unilateral in one of them.Follow-up at 24 months of age had shown normal verbal and non-verbal developmental scores.Language development and intelligence median (range) scores at 5 years of age were also normal: receptive language development 104 (55-133); syntactical development 104 (68-132); and lexical development 101 (50-141) for 89 children; intelligence quotient was 104 (68-132) in 106 children.Scores did not differ between those with normal hearing, and those with mild hearing loss, or those with moderate to severe hearing loss (p=0. 800, p=0.639, p=0.876, and p=0.886, for the respective developmental tests). CONCLUSIONS:We found normal language development and intelligence in a cohort of neonatal ECMO survivors. The prevalence of bilateral sensorineural hearing loss was in accordance with that of larger series in the United States -which exceeds the prevalence in the normal population.3

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The Respiratory System

Hutchison

Leclerc

Nève³

et al. 2014

Pediatric and Neonatal Mechanical Ventilation

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Prospective longitudinal evaluation of lung function during the first year of life after extracorporeal membrane oxygenation*

Cited by 23 publications

References 29 publications

Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation

Diagnosis-related deterioration of lung function after extracorporeal membrane oxygenation

Sensorineural Hearing Loss and Language Development Following Neonatal Extracorporeal Membrane Oxygenation

The Respiratory System

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