Prospective memory in adults with spina bifida

Dennis, Maureen; Nelson, Rebekah; Jewell, Derryn; Fletcher, Jack Μ.

doi:10.1007/s00381-010-1140-z

Cited by 21 publications

(20 citation statements)

References 37 publications

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“…26,37,38,105 Outcome assessments should include traditional neuropsychological assessments as well as interview-based measures of adaptive behavior and rating scales.…”

Section: Theme 4: Outcome In Hydrocephalus Neuropsychological Outcomesmentioning

confidence: 99%

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

McAllister

Williams

Walker

et al. 2015

JNS

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abbreviatioNs CPC = choroid plexus cauterization; DTI = diffusion tensor imaging; ETV = endoscopic third ventriculostomy; HCRN = Hydrocephalus Clinical Research Network; ICP = intracranial pressure; iNPH = idiopathic NPH; LPA = lysophosphatidic acid; NIH = National Institutes of Health; NPC = neural precursor cell; NPH = normal pressure hydrocephalus; NSC = neural stem cell; PreOL = precursor oligodendroglia; RCT = randomized controlled trial; SVZ = subventricular zone; TNF = tumor necrosis factor; VP = ventriculoperitoneal; VZ = ventricular zone. . International experts gave plenary talks, and extensive group discussions were held for each of the major themes.The conference emphasized patient-centered care and translational research, with the main objective to arrive at a consensus on priorities in hydrocephalus that have the potential to impact patient care in the next 5 years. The current state of hydrocephalus research and treatment was presented, and the following priorities for research were recommended for each theme. 1) Causes of Hydrocephalus-CSF absorption, production, and related drug therapies; pathogenesis of human hydrocephalus; improved animal and in vitro models of hydrocephalus; developmental and macromolecular transport mechanisms; biomechanical changes in hydrocephalus; and age-dependent mechanisms in the development of hydrocephalus. 2) Diagnosis of Hydrocephalus-implementation of a standardized set of protocols and a shared repository of technical information; prospective studies of multimodal techniques including MRI and CSF biomarkers to test potential pharmacological treatments; and quantitative and cost-effective CSF assessment techniques. 3) Treatment of Hydrocephalus-improved bioengineering efforts to reduce proximal catheter and overall shunt failure; external or implantable diagnostics and support for the biological infrastructure research that informs these efforts; and evidencebased surgical standardization with longitudinal metrics to validate or refute implemented practices, procedures, or tests. 4) Outcome in Hydrocephalus-development of specific, reliable batteries with metrics focused on the hydrocephalic 1427

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“…26,37,38,105 Outcome assessments should include traditional neuropsychological assessments as well as interview-based measures of adaptive behavior and rating scales.…”

Section: Theme 4: Outcome In Hydrocephalus Neuropsychological Outcomesmentioning

confidence: 99%

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

McAllister

Williams

Walker

et al. 2015

JNS

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“…In young adults with SBM, ranging in age from18 to 36 years, Dennis et al (2007) reported lower performance relative to TD individuals on a composite prospective memory score from the Rivermead Behavioural Memory Test (RBMT; Wilson, Cockburn, & Baddeley, 1985). In the only memory study to date that has included middle-aged adults with SBM (age range 18 to 63 years), Dennis et al (2010) reported poorer time- and event-based prospective memory performance on the Cambridge Prospective Memory Test (Wilson et al, 2005) among adults with SBM relative to TD adults.…”

Section: Memory In Sbmmentioning

confidence: 99%

“…Of particular importance when studying adults with SBM and other neurodevelopmental disorders is the question of accelerated normal or pathological aging (Dennis et al, 2010). Individuals with neurodevelopmental disorders other than SBM have been shown to exhibit more rapid cognitive aging and/or dementia neuropathology as early as 30 to 40 years of age (Devenny, Krinsky-McHale, Sersen, & Silverman, 2000; Hagerman & Hagerman, 2004).…”

Section: Memory In Sbmmentioning

confidence: 99%

“…As a result, there now exists a cohort of individuals ranging in age from young adulthood through middle age for whom there is little data on long-term neurobehavioral outcomes (Bowman & McLone, 2010; Dennis, Jewell, et al, 2007). The cognitive profile of individuals with SBM appears to be generally stable across development from childhood through young adulthood; however, there is recent evidence suggesting that memory may begin to deteriorate more rapidly in adults with SBM relative to expectations from childhood and typical adult development (Dennis, Nelson, Jewell, & Fletcher, 2010). …”

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confidence: 99%

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Prospective and episodic memory in relation to hippocampal volume in adults with spina bifida myelomeningocele.

Treble‐Barna¹,

Juranek

Stuebing

et al. 2015

Neuropsychology

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The present study examined prospective and episodic memory in relation to age, functional independence, and hippocampal volume in younger to middle-aged adults with spina bifida myelomeningocele (SBM) and typically developing (TD) adults. Prospective and episodic memory, as well as hippocampal volume, were reduced in adults with SBM relative to TD adults. Neither memory performance nor hippocampal volume showed greater decrements in older adults. Lower hippocampal volume was associated with reduced prospective memory in adults with SBM, and this relation was specific to the hippocampus and not to a contrast structure, the amygdala. Prospective memory mediated the relation between hippocampal volume and functional independence in adults with SBM. The results add to emerging evidence for reduced memory function in adults with SBM, and provide quantitative evidence for compromised hippocampal macrostructure as a neural correlate of reduced memory in this population.

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“…Recent studies have demonstrated that along with a variety of sensorimotor and cognitive deficits (Dennis et al, 2010;Simos et al, 2011), specific cognitive operations relying on the interhemispheric integration of function are significantly affected in children with SBH, most prominently in cases where partial agenesis of the corpus callosum is present (Hannay et al, 2008;Klaas et al, 1999). It is likely that compromised interhemispheric effective connectivity is a cause of this loss of function, especially considering the corresponding reduced anatomical connectivity.…”

Section: Introductionmentioning

confidence: 99%

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

Malekpour

Cheung

et al. 2012

Brain Connectivity

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The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the h and a bands.

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Prospective memory in adults with spina bifida

Abstract: Introduction-Individuals with neurodevelopmental disorders have been observed to show accelerated cognitive aging or even dementia as early as 30 and 40 years of age. Memory deficits are an important component of age-related cognitive loss.

Cited by 21 publications

References 37 publications

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

Prospective and episodic memory in relation to hippocampal volume in adults with spina bifida myelomeningocele.

Interhemispheric Effective and Functional Cortical Connectivity Signatures of Spina Bifida Are Consistent with Callosal Anomaly

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