Prospective memory in multiple sclerosis: The impact of cue distinctiveness and executive functioning

Dagenais, Emmanuelle; Rouleau, Isabelle; Tremblay, Alexandra; Demers, Mélanie; Roger, Élaine; Jobin, Céline; Duquette, Pierre

doi:10.1016/j.bandc.2016.07.011

Cited by 13 publications

(11 citation statements)

References 52 publications

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“…Additionally, PM deficits were shown to be associated with hippocampal atrophy, based on a VBM study in adults with spina bifida myelomeningocele (25). Some studies have shown that PM in patients with MS was impaired (7,(26)(27)(28). However, few studies have investigated the relationships between PM deficits and brain regions in patients with MS. Pardini et al reported that PM deficits were related to the reduced fractional anisotropy in the left uncinate fasciculus, using DTI (29).…”

Section: Discussionmentioning

confidence: 99%

“…Cognitive impairment is recognized as a core symptom of all phases and all subtypes of multiple sclerosis (MS) (4). Previous studies reported that general intelligence is preserved in MS, and PM in everyday life is one of the most affected cognitive domains in MS (5)(6)(7). Although MS is traditionally considered to be a demyelinating disease affecting the white matter (WM), gray matter (GM) atrophy and plaques in GM have been deemed crucial in cognitive disability of MS (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

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Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis

et al. 2021

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Objective Prospective memory (PM) is an important social cognitive function in everyday life. PM is one of the most affected cognitive domains in multiple sclerosis (MS) patients. Gray matter (GM) atrophy and plaques have been attracting attention for various cognitive impairments in MS patients. This study aimed to clarify the atrophic GM regions associated with PM deficits and investigate the relationship between the atrophic GM regions and GM plaques. Methods Twenty-one MS patients and 10 healthy controls (HCs) underwent neuropsychological tests and MRI. PM was assessed using subtests of the Rivermead Behavioural Memory Test. A lesion symptom analysis was performed using voxel-based morphometry (VBM). We then evaluated GM plaques in the corresponding areas using double inversion recovery (DIR). Results MS patients showed lower PM scores than HCs (p=0.0064). The GM volume of MS patients tended to be lower than those of HCs. VBM analyses revealed correlations of the PM score with the orbital part of the left inferior frontal gyrus, the left hippocampus, and the right parahippocampus. There was no GM plaque in the orbital part of the left inferior frontal gyrus and the right parahippocampus. Only one patient (4.8%) had GM plaque in the left hippocampus. Conclusion The left inferior frontal gyrus, the left hippocampus, and the right parahippocampus were associated with PM in MS, whereas these atrophic GM regions were not associated with GM plaque. Regardless of the location of plaques on DIR, both PM deficit and GM atrophy should be detected using neuropsychological tests and VBM in MS patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis

et al. 2021

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“…Impairments of PM are often associated with frontal dysfunctions in several neurological disorders (i.e. Parkinson’s disease, multiple sclerosis) (13,14).…”

Section: Introductionmentioning

confidence: 99%

Prospective memory is dysfunctional in migraine without aura

et al. 2018

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Introduction Prospective memory is the ability to carry out a delayed intended action, so to maintain and retrieve future plans, goals and activities. Deficits of prospective memory negatively impact on patients and caregivers' everyday living and determine poor adherence to treatment. Since frontal regions are involved in both event- and time-based prospective memory tasks and are impaired in migraine without aura, defects of prospective memory might occur in migraine without aura patients; until now this issue has not been investigated. The aim of the current study was to explore time- versus event-based prospective memory in migraine without aura. Patients and methods Ninty-one consecutive migraine without aura patients and 84 healthy subjects were enrolled in the study. They underwent a standardized measure of prospective memory evaluating both time-based and event-based prospective memory, and the Montreal Cognitive Assessment assessing global cognitive status. Moreover, all participants completed the Beck Depression Inventory-II and a self-administered version of the Apathy Evaluation Scale, to assess severity of depressive symptoms and apathy, respectively. Results Migraine without aura and healthy subjects did not differ on demographic aspects (i.e. age, education and gender). However, individuals with migraine without aura demonstrated impaired prospective memory performance compared to healthy subjects, with a greater impairment demonstrated for the time-based tasks. Within the migraine without aura group, no significant association was found between prospective memory performance and clinical scores, apathy, and depression. Conclusions Individuals with migraine without aura experience particular difficulty executing a future intention; therefore, migraine without aura is associated with dysfunction of prospective memory.

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“…38 A relationship between EF and PM has been observed. 39 Several studies have shown that PM requires both RM and EF. Dagenais et al, 39 examining the influence of EF on pMS PM, revealed that good performance is modulated by the efficiency of EF, while RM appears to have a minimal impact on PM performance.…”

Section: Executive Functionsmentioning

confidence: 99%

Cognitive impairment in multiple sclerosis: “classic” knowledge and recent acquisitions

2023

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Multiple sclerosis (MS) is a central nervous system (CNS) disease characterized by inflammation, axonal demyelination, and neurodegeneration, which can have a strong impact on all aspects of the life of the patient. Multiple sclerosis causes motor, sensory, cerebellar, and autonomic dysfunctions, as well as cognitive and psychoemotional impairment. The most frequently compromised cognitive domains are complex attention/information processing, memory, executive and visuospatial functions. Recently, alterations have also been evidenced in complex cognitive functions, such as social cognition, moral judgment, and decision-making. Cognitive impairment is characterized by high variability and can affect work skills, social interactions, coping strategies and more generally the quality of life of patients and their families. With the use of sensitive and easy-to-administer test batteries, an increasingly accurate and early diagnosis is feasible: this allows to determine the effectiveness of possible preventive measures, to predict the future progression of the disease and to improve the quality of life of patients. There is currently limited evidence regarding the efficacy, on cognitive impairment, of disease-modifying therapies. The most promising approach, which has received strong empirical support, is cognitive rehabilitation.

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Prospective memory in multiple sclerosis: The impact of cue distinctiveness and executive functioning

Cited by 13 publications

References 52 publications

Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis

Prospective Memory Deficits in Multiple Sclerosis: Voxel-based Morphometry and Double Inversion Recovery Analysis

Prospective memory is dysfunctional in migraine without aura

Cognitive impairment in multiple sclerosis: “classic” knowledge and recent acquisitions

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