Prospective monitoring of early fetal loss and clinical spontaneous abortion among female semiconductor workers

Abstract

Women who work in silicon wafer fabrication rooms (fabs) have been reported to have an increased risk of spontaneous abortion (SAB). Although previous studies have included only clinically recognized SABs, more than two-thirds of SABs may be clinically unrecognized. To determine whether fab work is associated with SAB, we recruited 152 fab and 25 1 nonfab workers, who collected urine samples for a 6-month period. Samples

Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso

“…In SWHS, we have previously reported a longer time to pregnancy and increased odds of infertility associated with TCDD exposure (Eskenazi et al 2010). If the most highly exposed women could not achieve or maintain pregnancy, they would not be included in our analytic sample (Eskenazi et al 1995; Wilcox et al 1988). Therefore, we may have underestimated the effect of TCDD exposure on birth outcomes by not including those women that may have been the most susceptible.…”

Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention: A pooled analysis of 11 clinical trials

“…Results show the HPV-16/18 AS04-adjuvanted cervical cancer vaccine to be generally well-tolerated, with a favorable safety similar frequent and sensitive pregnancy testing and in which women were followed longitudinally from early in the gestation period (28.7-45.5%). 21,[23][24][25][26] For long-term prophylactic efficacy, a cervical cancer vaccine needs to induce a strong humoral and cellular response. 27,28 Adjuvants have long been used to enhance and/or modulate the immune response to vaccine antigens.…”

“…However, this rate was lower than the corresponding rate observed in women aged >25 years who received Al(OH) 3 and was within the range of published incidence rates of spontaneous abortions in the US (9.1-45.5%). [20][21][22] The wide range of published incidence rates for spontaneous abortions is most likely due to the significant variability in the medical literature in terms of the outcomes included as fetal loss due to spontaneous abortion, especially regarding the inclusion of outcomes such as ectopic and molar pregnancy. In the HPV-16/18 vaccine studies, pregnancy testing was performed at each vaccination visit.…”

Bekanntmachung des Umweltbundesamtes: Stoffmonographie für Glykolether, die zu Methoxyessigsäure verstoffwechselt werden – Referenz- und Human-Biomonitoring (HBM)-Werte für Methoxyessigsäure im Urin

“…Eine verminderte Fertilität und eine erhöh-te Anzahl von Fehlgeburten in der Halbleiterindustrie wurde mit der Exposition gegenüber Glykolethern/EGME, EGEE und deren Acetaten in Verbindung gebracht [38,39,40]. Zwei Fälle von Hypospadie wurden im Kausalzusammenhang mit einer hohen Exposition (inhalativ und dermal) gegenüber EGMEA wäh-rend der Schwangerschaft beschrieben [41].…”