Prospective multicenter study on the usefulness of EUS-guided FNA biopsy for the diagnosis of autoimmune pancreatitis

Branch Duct Intraductal Papillary Mucinous Neoplasms of the Pancreas Involving Type 1 Localized Autoimmune Pancreatitis with Normal Serum IgG4 Levels Successfully Diagnosed by Endoscopic Ultrasound-guided Fine-needle Aspiration and Treated without Pancreatic Surgery

“…In the report of Kanno et al (12), the percentage of the diagnostic ability of EUS-FNA for Level 1 LPSP and level 1 or 2 LPSP was 41% (32/78) and 57.7% (45/78) in 78 cases of suspected AIP, respectively, while in the report of Morishima et al (13), these respective values were 7.9% (3/38) and 65.8% (25/38) in 38 cases of definitive AIP. These findings indicate that level 2 or more LPSP can be diagnosed in almost 60% of patients with AIP in whom EUS-FNA has been performed, and that EUS-FNA can improve the diagnostic ability for AIP for many patients with AIP.…”

“…Recently, two multicenter prospective studies on the diagnostic ability of EUS-FNA using a 22-G needle for patients with suspected AIP have been reported (12,13). In the report of Kanno et al (12), the percentage of the diagnostic ability of EUS-FNA for Level 1 LPSP and level 1 or 2 LPSP was 41% (32/78) and 57.7% (45/78) in 78 cases of suspected AIP, respectively, while in the report of Morishima et al (13), these respective values were 7.9% (3/38) and 65.8% (25/38) in 38 cases of definitive AIP.…”

Clinical use of endoscopic ultrasound-guided fine-needle aspiration: Guidelines and recommendations from Chinese Society of Digestive Endoscopy

“…Only surgical or core biopsies are adequate for definitive diagnosis (specimens extracted through EUS-FNA providing too little tissue). [31] Nevertheless, there is recent evidence that EUS-FNA is safe and reliable in histologic documentation of AIP. [32] The diagnostic yield is not high, but surgery may be avoided in those patients who lack distinctive features of AIP[33]…”

Autoimmune Pancreatitis in Germany: Rare but Relevant

“…Whether the higher incidence of AIP-type 1 in Korea and Japan is a matter of different diagnostic approaches or genetic background is an ongoing debate. However, a prospective multicenter study from Japan showed that endoscopic ultrasonography (EUS)-guided fine needle aspiration was only able to diagnose AIP in 3 out of 38 patients (sensitivity of 7%) [6]. This study highlights the current dilemma in the diagnosis of AIP-type 2 and, also explains why almost one third of patients with AIP underwent surgical procedures unnecessarily.…”