Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

McCormack, Rachel L.; Olley, Louise; Glanemann, Barbara; Swann, James

doi:10.1038/s41598-020-72950-3

Cited by 16 publications

(44 citation statements)

References 37 publications

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“…Routine administration of PPIs seems to occur frequently in the hospital setting, including for the treatment of nausea, vomiting, or both despite no pharmacologic evidence for an anti-nausea or antiemetic effect of PPIs. 7 These conditions include nonerosive gastritis, pancreatitis, and hepatic and renal injury. Proton pump inhibitors also often are used as prophylaxis against GUE for diseases in which the benefit of PPI use (eg, non-hyperacidity diseases) is largely unknown as well as in combination with NSAIDs, which is not currently recommended.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of proton pump inhibitor administration in hospitalized dogs in a tertiary referral hospital

Duxbury

Sorah

Tolbert

2022

Veterinary Internal Medicne

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Background Although proton pump inhibitors (PPIs) are commonly administered to hospitalized dogs, prescribing patterns and appropriateness of use require continued investigation. Hypothesis/Objective Describe prescription patterns and appropriateness of use associated with PPIs in hospitalized dogs at a single tertiary care facility. We hypothesized that the majority of prescriptions would not comply with current guidelines for the rational use of acid suppressants. Animals Two hundred randomly selected hospitalized dogs. Methods Retrospective evaluation of the medical records associated with a randomly selected sample of hospitalized dogs that received PPIs between January 2013 and December 2018. Results A total of 12 610 dogs were admitted for first‐time hospitalization between January 2013 and December 2018. Forty percent of these dogs (5062/12610) were prescribed a PPI PO or IV. Of the 200 randomly selected records, an adequate indication for use was identified in 27% of dogs (54/200). Of the dogs surviving to discharge, 54% (95/175) were discharged with a PPI and 51.6% (49/95) of those were prescribed an inadequate dose. Conclusions and Importance Our findings support other studies in which the majority of PPI prescriptions for hospitalized dogs at a tertiary care hospital lacked an appropriate indication. Furthermore, analysis of the prescribing patterns of dispensed PPIs identified a frequent occurrence of dosages considered inadequate, raising concern for ineffective treatment even with appropriate indications of use. With growing concern of adverse effects associated with PPI and other acid suppressant administration in human and veterinary medicine, rational use of these medications following consensus guidelines should be emphasized and treatment should be reserved for dogs with historical, physical examination, clinicopathologic, and imaging findings supportive of an appropriate indication for use.

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Section: Discussionmentioning

confidence: 99%

Evaluation of proton pump inhibitor administration in hospitalized dogs in a tertiary referral hospital

Duxbury

Sorah

Tolbert

2022

Veterinary Internal Medicne

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“…The dog also received a proton‐pump inhibitor during initial hospitalisation, which was subsequently discontinued in line with the recent ACVIM consensus statement 12 . Overutilisation of proton‐pump inhibitors is common, and veterinarians are urged to consider whether they are definitively indicated before utilisation 13 …”

Section: Discussionmentioning

confidence: 99%

“…12 Overutilisation of proton-pump inhibitors is common, and veterinarians are urged to consider whether they are definitively indicated before utilisation. 13…”

Section:  Of mentioning

confidence: 99%

Corpus callosum abnormality in a puppy with hypernatraemia

Cridge

Zoto

Milne³

et al. 2022

Vet Record Case Reports

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A 3‐month‐old, female, entire, mixed breed dog presented for a 1‐day history of ataxia and a 7‐day history of gastrointestinal upset. Neurologic examination revealed dull mentation, head pressing and bruxism. The dog had generalised coarse tremors during ambulation and cervical ventroflexion. Cranial nerve examination, postural reactions and myotatic reflexes were normal. The dog was markedly hypernatraemic at 202 mmol/L (139–151 mmol/L) and was assessed to be non‐hypervolaemic. The dog received custom fluids, and once stabilised, underwent magnetic resonance imaging. Magnetic resonance imaging revealed agenesis of the rostral portion and hypoplasia of the caudal portion of the corpus callosum. Absence of the septum pellucidum and a cortical development abnormality were noted with fusion of the ventral portion of the frontal lobes and malformation of the cingulate gyrus. Cerebrospinal fluid revealed an elevated total protein with a mild lymphocytic and macrophagic pleocytosis. The dog responded well to increased dietary moisture.

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“… 16 The PPIs and other gastroprotectants are often used inappropriately and overprescribed by general practitioners and veterinary specialists. 17 , 18 , 19 The authors advise judicious use of this medication for dogs where severe GI bleeding, treatment compliance, or both is a concern.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a long‐acting injectable formulation of omeprazole in healthy dogs

Odunayo

Galyon

Price

et al. 2022

Veterinary Internal Medicne

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Background: To evaluate the efficacy of a single intramuscular adminsitration of long-acting omeprazole (LA-OMEP) in increasing gastric pH in dogs.Hypothesis: We hypothesized that LA-OMEP would meet in healthy dogs the clinical goals defined for human patients for treatment of gastroduodenal ulceration. Animals: Nine healthy research dogs.Methods: Prospective experimental study. Dogs were given a 4 mg/kg intramuscular injection of LA-OMEP. Intragastric pH was continuously recorded on treatment days 0 to 7. Daily mean pH and mean percentage time (MPT) intragastric pH was ≥3 or ≥4 were determined. Results:The mean onset of action for the LA-OMEP was 98.11 min (SD 46.39). The mean number of days the dogs' pH met established goals for MPT pH ≥3 was 5.5 days (range, 3-7) and 5.25 days for MPT pH ≥4 (range, 3-7). Long-acting omeprazole met the human clinical goals pH ≥3 for 72 hours in 8/8 of the dogs and MPT pH ≥4 for 96 hours in 7/8 of dogs.Conclusions and Clinical Importance: The LA-OMEP formulation produced gastric acid suppression in healthy dogs for an average of 5 days and up to 7 days, after a single intramuscular injection. No major adverse effects were observed.acid suppression, bravo monitoring, canine intragastric pH, proton pump inhibitor | INTRODUCTIONGastrointestinal (GI) bleeding is common in critically ill dogs and is a cause of increased morbidity and case fatality. 1,2 Clinical signs of GI bleeding include anorexia, lethargy, vomiting, abdominal pain, hematemesis, melena, and hematochezia. 3,4 Central to the treatment of upper GI bleeding is inhibition of gastric acid suppression through the administration of gastric acid-suppressant treatment. 1,4,5 In human patients, the use of proton pump inhibitors (PPIs) reduces both bleeding risk and the need for endoscopic intervention in bleeding patients. 4,6 Suppressing gastric acid production and maintaining intragastric pH ≥3 and ≥4 for 75% and 67% of the day promotes the healing of duodenal ulcers and gastroesophageal reflux disease in human patients, respectively. 7,8

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Prospective observational study of the use of omeprazole and maropitant citrate in veterinary specialist care

Cited by 16 publications

References 37 publications

Evaluation of proton pump inhibitor administration in hospitalized dogs in a tertiary referral hospital

Evaluation of proton pump inhibitor administration in hospitalized dogs in a tertiary referral hospital

Corpus callosum abnormality in a puppy with hypernatraemia

Evaluation of a long‐acting injectable formulation of omeprazole in healthy dogs

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