Prospective of guar gum and its derivatives as controlled drug delivery systems

Anin situcrosslinked compression coat comprised of pectin and calcium chloride for colon-specific delivery of indomethacin

“…Among the different approaches that have been developed for the purpose of drug administration to the colon, polysaccharide-based CSDDS have demonstrated better colon-specificity when compared with either pH-or time-dependent delivery systems, likely due to selective degradation by colonic microflora (Basit et al, 2009;Shah et al, 2011). Polysaccharides that have been well established for use in colon-specific drug delivery include pectin, guar gum, chitosan, amylose, inulin, dextran and alginate (Liu et al, 2007;Prabaharan, 2011;Shah et al, 2011;Gulbake & Jain, 2012). Polysaccharide-based matrix and coated systems based on polysaccharide have been developed for colonspecific delivery of a variety of active ingredients (Basit, 2005;Prabaharan, 2011).…”

Nanotechnology: the word is new but the concept is old. An overview of the science and technology in food and food products at the nanoscale level

“…Compounds capable of forming inclusion complexes with biologically active agents can serve as vehicles for pharmaceutical, food, cosmetic and other applications (Kurkov, Ukhatskaya, & Loftsson, 2011). As natural biomaterials, polysaccharides are highly stable, safe, non-toxic, hydrophilic, biodegradable, abundantly available, and have a low cost in their processing (Prabaharan, 2011). Lipids also serve as carriers of bioactives, and have been recently reviewed (Fathi et al, 2012).…”

“…Guar gum and its derivatives have also been employed as controlled drug delivery systems, and developments in this area have been summarised recently (Prabaharan, 2011). Guar gum and its derivatives have been applied as colon specific, antihypertensive, protein, as well as transdermal drug delivery systems.…”

“…Guar gum and its derivatives have been applied as colon specific, antihypertensive, protein, as well as transdermal drug delivery systems. As with cyclodextrins, different methods of preparation, properties and applications of chemically modified guar gum have been designed for the association and delivery of drugs in various scenarios (Prabaharan, 2011). Guar gum (Yan, Chang, Zheng, & Ma, 2012) as well as starch (Yan, Chang, & Zheng, 2011) were recently used to improve the solubility of carbon nanotubes, whose wide spectra of uses include efficient adsorption for removing many kinds of organic and inorganic contaminants, accomplished via their grafting to the exterior of the nanotubes.…”

“…To aid food scientists navigate these, we have summarised various recent food nanoscience and technology reviews (see Table 1). In the past year alone, food-related reviews have been published on packaging (Bradley, Castle, & Chaudhry, 2011;Duncan, 2011b), nanotechnology safety (Card, Jonaitis, Tafazoli, & Magnuson, 2011;Magnuson & Bouwmeester, 2011;Teow, Asharani, Hande, & Valiyaveettil, 2011), detection of nanomaterials in food (Blasco & Picó, 2011), drug delivery using food material-based nanoencapsulation (Elzoghby, El-Fotoh, & Elgindy, 2011;Prabaharan, 2011), ingredient nanoencapsulation (Fathi, Mozafari, & Mohebbi, 2012), engineered nanomaterials (Morris, 2011), communication (Duncan, 2011a, starch nanocrystals, (Lin, Huang, Chang, Anderson, & Yu, 2011a) as well as general reviews (Neethirajan & Jayas, 2011;Rashidi …”