2022
DOI: 10.1136/bmjopen-2021-052192
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Prospective open-label non-inferiority randomised controlled trial comparing letrozole and mifepristone pretreatment in medical management of first trimester missed miscarriage: study protocol

Abstract: IntroductionMedical treatment is a less invasive alternative to surgical management of missed miscarriage. Studies have shown that pretreatment with mifepristone can increase the complete abortion rate in management of first-trimester missed miscarriage compared with misoprostol alone. Two studies have also shown that pretreatment with letrozole could increase the efficacy compared with misoprostol alone. So far, there is no trial comparing letrozole and mifepristone pretreatment for missed miscarriage. We des… Show more

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“…After obtaining written informed consent, randomisation was carried out as described below. The protocol, including the statistical analysis plan, has been published previously 23 …”
Section: Methodsmentioning
confidence: 99%
“…After obtaining written informed consent, randomisation was carried out as described below. The protocol, including the statistical analysis plan, has been published previously 23 …”
Section: Methodsmentioning
confidence: 99%