Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Abstract

Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects have attracted growing interest from the scientific community and pharmaceutical companies. A literature search was carried out to collect published research information on the effects of resveratrol on kidney aging. Recently, resveratrol has emerged as a potential anti-aging agent. This versatile polyphenol exerts its anti-aging effects by intervening in various pathologies and multi-signaling systems, including sirtuin type 1, AMP-activated protein kinase, and nuclear factor-κB. Researchers are trying to figure out the detailed mechanisms and possible resveratrol-mediated interventions in divergent pathways at the molecular level. This review highlights (i) the causative factors implicated in kidney aging and the therapeutic aspects of resveratrol, and (ii) the effectiveness of resveratrol in delaying the aging process of the kidney while minimizing all possible side effects.

Renoprotective potentials of small molecule natural products targeting mitochondrial dysfunction

“…The inactivation of SIRT1 and the activation of the renin-angiotensin system, oxidative stress, and mitochondrial dysfunction are associated with aging (Kim et al, 2018). A recent study has assessed the potential use of resveratrol in delaying kidney aging (Uddin et al, 2021). Administration of resveratrol at 40 mg/kg for 6 months in 24-month-old C57BL/mice prevented aging-related kidney damage by activating Nrf-2 and SIRT1 signaling and ROS suppression.…”

Exosomes: A novel insight into traditional Chinese medicine

“…Resveratrol is also enriched in the root of Polygonum cuspidatum , a well-known traditional Chinese medicine ( Hu and Li, 2019 ). It is quite famous for various biological effects, including antioxidative, anti-tumor, anti-inflammation, anti-fibrosis, and neuroprotective activities ( Parsamanesh et al, 2021 ; Uddin et al, 2021 ). Despite its potential for these effects on multiple diseases, the clinical usage of resveratrol is limited due to its pharmaceutical limitations, such as low bioavailability and poor bioavailability ( Robertson et al, 2022 ).…”

Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging

“…These typical hallmarks contribute to the aging process, together determining the aging phenotype and increasing vulnerability to death [ 2 ]. Currently, healthy aging emerged as a crucial issue due to the recent increase of the geriatric population worldwide [ 3 , 4 ]. Therefore, a great deal of effort to overcome age-related impairments is devoted to identifying potential risk factors together with novel therapeutic strategies, also non-pharmacological, and discovering natural substances that may prevent/revert the adverse effects of aging.…”