Prospective phase II trial of cetuximab plus VMAT-SIB in locally advanced head and neck squamous cell carcinoma

Abstract

The here reported toxicity data are promising and encouraging in regard to the adoption of moderate hypofractionation with VMAT-SIB techniques, when cetuximab is concomitantly administered.

Incidence of mucositis in patients with head and neck squamous cell carcinoma treated with radiotherapy plus cetuximab: a pilot study

“…Alongi et al reported 9% of grade 1, 36% of grade 2 and 45% of grade 3 mucositis in a series of 22 elderly and chemotherapy-ineligible patients treated with radiotherapy plus cetuximab [14]. The results obtained in our pilot study are similar, as 60% of patients had grade 1 to 2 mucositis, and 40% of patients had grade 3 to 4 mucositis.…”

Predictors of mucositis in oropharyngeal and oral cavity cancer in patients treated with volumetric modulated radiation treatment: A dose–volume analysis

“…9 In the era of dose painting intensity-modulated radiation therapy, it becomes crucial to spare healthy structures to improve the patient's quality of life. Volumetric modulated arc therapy (VMAT) has been evaluated for patients with head and neck cancer [10][11][12][13][14] showing that it is a fast, safe, and accurate technique.…”

Dose–volume-related dysphagia after constrictor muscles definition in head and neck cancer intensity-modulated radiation treatment

“…3 Intensity-modulated radiation therapy (IMRT) and rotational intensity-modulated techniques, including volumetricmodulated arc therapy (VMAT), allow for a better dose conformation to target structures while reducing the dose. [4][5][6][7][8] In comparison with three-dimensional-conformal radiation therapy, several studies have shown that IMRT in HNC treatment reduces overall adverse effects such as xerostomia and dysphagia and thus improves QoL, even when chemotherapy is added. [9][10][11][12][13] Regarding tolerance of the parotid glands, several studies have suggested significant recovery when the mean dose is inferior to 26 Gy.…”