Prospective randomised trial in 1062 infants of diet low in saturated fat and cholesterol

Lapinleimu, Helena; Salo, Pia; Routi, Taina; Jokinen, Eero; Välimäki, Ilkka; Simell, Olli; Viikari, Jorma; Rönnemaa, Tapani

doi:10.1016/s0140-6736(95)90580-4

Cited by 190 publications

(146 citation statements)

References 18 publications

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“…Simell and co-workers (Lapinleimu et al, 1995;Simell et al, 2000) suggested that lower fat intake is advantageous not only for adults, but also for young children, because a diet low in saturated fat and cholesterol affects serum lipids in a healthy way. Although, their intervention study included both qualitative and quantitative changes, emphasis was on the reduction of SAFA.…”

Section: Dietary Fat Intake (E%)mentioning

confidence: 99%

Dietary fat in infancy should be more focused on quality than on quantity

et al. 2007

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Objective: The primary aim was to assess, the association of the quantity and quality of dietary fat intake from 6 to 12 months of age and serum lipids at 12 months. Subjects/Methods: Three hundred healthy term Swedish infants were recruited in a longitudinal prospective study at the age of 6 months; 276 remained in the study at 12 months. Food records and anthropometric data were collected monthly from 6 to 12 months; serum lipids were analysed at 6 and 12 months. Results: Swedish infants had a total fat intake within the Nordic recommendations, but intake of polyunsaturated fatty acids (PUFA) was low (5.6 percent of total energy (E%)) and intake of saturated fatty acids (SAFA) was high (15.1 E%). Higher PUFA intake was associated with lower total serum cholesterol (TC, B ¼ À0.13, P ¼ 0.003), lower low-density-lipoprotein cholesterol (LDL-C, B ¼ À0.12, P ¼ 0.004) and apolipoprotein B (B ¼ À0.03) (P ¼ 0.034) in girls but not in boys. When data from the present study were compared to data from similar studies in Finland and Iceland, it appears that the quality of the dietary fat has greater impact on serum lipid levels than the quantity of fat in the diet. Conclusions: Higher PUFA and lower SAFA intakes may reduce TC and LDL-C early in life, particularly in girls. Further, with respect to lowering serum lipid concentrations in early childhood it seems appropriate to set focus on fat quality rather than the quantity.

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Section: Dietary Fat Intake (E%)mentioning

confidence: 99%

Dietary fat in infancy should be more focused on quality than on quantity

et al. 2007

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“…In a prospective, randomised coronary heart disease risk factor intervention trial (the STRIP project) families were recruited to the study by nurses at the well-baby clinics in the city of Turku, Finland, at infants' routine 5-month visit between December 1989 and May 1992 as described (Lapinleimu et al, 1995;Niinikoski et al, 1996). The 1062 infants were allocated into an intervention group (N ¼ 540) or a control (522) group by random numbers at the 7-month visit.…”

Section: Design and Subjectsmentioning

confidence: 99%

Longitudinal trends in consumption of vegetables and fruit in Finnish children in an atherosclerosis prevention study (STRIP)

et al. 2005

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Objective: To assess prospectively the consumption of fruit and vegetables and its' correlation to the parental consumption in boys and girls taking part in an atherosclerosis prevention study (Special Turku Coronary Risk Factor Intervention Project for Children (STRIP) study). Hypothesis: Nutrition counselling focused on cardiovascular health effects vegetable and fruit consumption. Design: A prospective, randomised, clinical trial. Subjects: Children were recruited to the STRIP study between 1989 and 1992. At the age of 7 months, children were randomised to the intervention (n ¼ 540) or the control group (n ¼ 522) and were followed up until the age of 11 years. Intervention: Families in the intervention group have, since randomisation, received biannual individualised dietary counselling aimed at reduction of cardiovascular risk factors, especially saturated fat intake. Food records were used to assess fruit and vegetable consumption of children and parents. Results: The percentage of total energy intake provided by fruit and vegetables decreased when the children grew older (P for age o0.001). The 1-to 10-year-old intervention boys consumed more vegetables (mean difference 3.18 g/day; CI 1.48-4.86; Po0.001) and fruit (mean difference 10.1 g/day; CI 5.28-14.94; Po0.001) than did the control. Mother's consumption correlated with the consumption of their daughters and sons, whereas father's consumption correlated only with the consumption of their sons. Conclusions: Finnish children taking part in the atherosclerosis prevention study had a remarkably low fruit and vegetable consumption, which furthermore decreased with age. The children's consumption correlated with the parental consumption, except between boys and mothers. A slight intervention effect was present only among boys.

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“…The intervention children have continuously had lower intake of saturated fat and cholesterol than the control children have during the ®rst 5 y of life. Total fat intake of the intervention children has also been slightly lower than that of the control children, and the differences in serum cholesterol concentration has been between 3% and 10% during the follow up (Lapinleimu et al, 1995;Niinikoski et al, 1996;Lagstro Èm et al, 1997). To elucidate how strongly child-targeted nutrition counselling given to the parents during the previous 6.5 y in¯uences children's nutrition knowledge and recorded food intake at the age of 7 y, we selected a time-restricted cohort of the intervention and control children from the STRIP project and used a pictureidenti®cation knowledge test developed for the project and children's food diaries to compare outcome in these two groups of children.…”

Section: Introductionmentioning

confidence: 95%

Nutrition knowledge and food intake of seven-year-old children in an atherosclerosis prevention project with onset in infancy: the impact of child-targeted nutrition counselling given to the parents

et al. 2001

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Objective: To compare nutrition knowledge and food intake in 7-y-old intervention and control children in an atherosclerosis risk factor intervention trial after 6.5 y of nutrition counselling given to the parents. Design, subjects and methods: Intervention families in the Special Turku Coronary Risk Factor Intervention Project received child-oriented nutritional counselling one to three times a year since child's age of 7 months, aimed at reduced saturated fat and cholesterol intake. Children's nutrition knowledge was analysed in a timerestricted cohort of 70 seven-y-old (34 boys) intervention children and 70 control children (40 boys) with a picture identi®cation test. For comparison, children's food intake was evaluated using scores developed for the project that re¯ected quality and quantity of fat and quantity of salt in children's two or three 4-day food diaries recorded between 5.5 and 7 y of age. Results: Child-targeted nutrition counselling of the intervention families only slightly increased intervention children's knowledge of heart-healthy foods (42.6% vs 34.9% correct answers by the intervention and control children, P 0.057). Only 20% of the children were able to adequately justify their answers in the test. The food diaries of the intervention children comprised more foods low in saturated fat and high in unsaturated fat than those of the control children (57.1% vs 41.7% of the maximum score for low fat foods, P 0.0001; 48.9% vs 37.7% for high unsaturated fat foods, P 0.0009, respectively), but the intervention and control children consumed similar amounts of low-salt foods (P 0.23). Nutrition knowledge and food use scores correlated poorly (r 70.20 ± 0.35). Conclusions: Child-targeted nutrition counselling repeatedly given to the parents during and after child's infancy strongly in¯uenced food choice scores of the 5.5 ± 7-y-old children but failed to in¯uence children's salt intake or scores in a nutrition knowledge picture test.

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Prospective randomised trial in 1062 infants of diet low in saturated fat and cholesterol

Cited by 190 publications

References 18 publications

Dietary fat in infancy should be more focused on quality than on quantity

Dietary fat in infancy should be more focused on quality than on quantity

Longitudinal trends in consumption of vegetables and fruit in Finnish children in an atherosclerosis prevention study (STRIP)

Nutrition knowledge and food intake of seven-year-old children in an atherosclerosis prevention project with onset in infancy: the impact of child-targeted nutrition counselling given to the parents

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