Prospective Randomized Comparison of Propylthiouracil

Gwinup, Grant

doi:10.1001/jama.1978.03280500053019

Cited by 19 publications

(6 citation statements)

References 9 publications

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“…The 20 percent effectiveness in the induction of euthyroidism with a single daily dose of 150 mg of PTU observed in this study is not consistent with the results of others which have shown that single daily dosages of 300–450 mg of PTU are effective in 58–78% of the patients in the induction of euthyroidism (Greer et al ., 1965; Kammer & Srinivasan, 1969; Gwinup, 1978). The discrepancy of the efficacy in the induction of euthyroidism between the present study and other studies might be due to the difference in daily dosages of PTU used for the treatment of hyperthyroidism.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, single daily dosage of 15–30 mg of MMI is also accepted as an alternative regimen to the divided dose regimen for the treatment of hyperthyroidism (Utiger, 1995; Cooper, 2000). In contrast, fewer studies on the efficacy of the treatment with single daily dose of PTU were reported and its effectiveness in the induction of euthyroidism was 60–78% (Greer et al ., 1965; Kammer & Srinivasan, 1969; Gwinup, 1978). However, the single daily dose regimen of PTU has been shown to be less effective than the divided dose regimen (Gwinup, 1978).…”

mentioning

confidence: 99%

“…In contrast, fewer studies on the efficacy of the treatment with single daily dose of PTU were reported and its effectiveness in the induction of euthyroidism was 60–78% (Greer et al ., 1965; Kammer & Srinivasan, 1969; Gwinup, 1978). However, the single daily dose regimen of PTU has been shown to be less effective than the divided dose regimen (Gwinup, 1978). Therefore, single daily dose regimen of PTU is generally not recommended for the treatment of hyperthyroidism (Cooper, 2000; Reed Larsen et al ., 1998).…”

mentioning

confidence: 99%

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Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism

Homsanit

Sriussadaporn

Vannasaeng

et al. 2001

Clinical Endocrinology

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During 12-weeks' treatment of Graves' hyperthyroidism, a single daily dose of 15 mg of MMI was much more effective in the induction of euthyroidism than a single daily dose of 150 mg of PTU. Once daily regimen of MMI not only decreased serum T3 and T4 levels more rapidly but also induced euthyroidism four times more effectively than did the once daily regimen of PTU. In the doses used in this study, MMI is preferable to PTU when a once-daily regimen of antithyroid drug is considered for the treatment of hyperthyroidism.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism

Homsanit

Sriussadaporn

Vannasaeng

et al. 2001

Clinical Endocrinology

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“…In comparison to the doses used clinically (200–600 mg person −1 day −1 , p.o., Astwood, 1967 ; Gwinup 1978 ; McMurry et al ., 1975 ; Clark et al ., 1992 ), the dose of PTU used in our in vivo study (10–20 mg kg −1 , i.v. i.e.…”

Section: Discussionmentioning

confidence: 99%

Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells

Chiao¹,

H²,

Wang

et al. 2000

British J Pharmacology

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1 The aim of this study was to investigate the mechanism by which propylthiouracil (PTU) exerts its inhibitory e ects on the production of testosterone by rat testicular interstitial cells. 2 The plasma testosterone concentration was decreased 60 and 120 min after an intravenous infusion of PTU (10 or 20 mg kg 71 ), but the concentration of plasma T 4 was una ected by the drug treatment.3 Exposure of anterior pituitary tissue to PTU (3 ± 12 mM) in vitro did not a ect either basal or gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release. 4 PTU (3 ± 12 mM) inhibited both the basal and the human chorionic gonadotropin (hCG, 0.05 iu ml 71 )-stimulated release of testosterone from rat testicular tissue in vitro; at the highest concentration tested (12 mM), it also inhibited the forskolin or 8-bromo-adenosine 3':5'-cyclic monophosphate (8-Br-cyclic AMP)-stimulated release of testosterone. 5 The 25-OH-cholesterol (10 77 ± 10 75 M)-stimulated release of pregnenolone and testosterone by the testicular interstitial cells was inhibited by PTU (12 mM, P50.05). 6 The results suggest that the inhibitory actions of PTU on testosterone secretion are exerted, at least in part, at the testicular level through a mechanism which is independent of thyroid status and which involves a reduction in P450scc activity and, hence, in the conversion of cholesterol to pregnenolone.

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“…However, a number of studies have consistently shown that the single daily dose of MMI is effective in the treatment of hyperthyroidism (Bouma & Kammer, 1980; Shiroozu et al ., 1986; Roti et al ., 1989; Mashio et al ., 1997). In contrast, previous studies have concluded that PTU can be successfully given to patients with Graves’ disease as a single daily dose (Greer et al ., 1965; Gwinup, 1978). However, the single daily dose regimen of PTU has been shown to be less effective than the divided dose regimen (Gwinup, 1978).…”

mentioning

confidence: 99%

Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves’ hyperthyroidism

He¹,

Hsieh²,

Pei³

et al. 2004

Clinical Endocrinology

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Prospective Randomized Comparison of Propylthiouracil

Cited by 19 publications

References 9 publications

Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism

Efficacy of single daily dosage of methimazole vs. propylthiouracil in the induction of euthyroidism

Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells

Comparison of single daily dose of methimazole and propylthiouracil in the treatment of Graves’ hyperthyroidism

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